Primary Laryngeal Lymphoma: Case Report

Abstract

Extranodal laryngeal lymphoma is extremely rare. We report a case of primary laryngeal lymphoma in a 76-year-old man who had presented with a 7-week history of progressive hoarseness. Laryngoscopy revealed asymmetry of the right false vocal fold. Pathology of a deep biopsy specimen identified a malignant, diffuse, CD20-positive, B-cell lymphoma. The stage IE lymphoma completely resolved after treatment with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) and rituximab. Despite its relative rarity, the consequences of a missed diagnosis warrant vigilance for this type of laryngeal tumor.

Staging and Survival Analysis for Nonsquamous Cell Carcinomas of the Larynx

“…Hematopoietic neoplasms of the larynx are rare examples of extranodal lymphoma, representing less than 1% of all primary malignant laryngeal tumors 12 . Roughly 90 cases of laryngeal lymphoproliferative tumors have been reported 13 . These tumors are thought to arise from one of two potential locations within the larynx: 1) specialized submucosal aggregates of lymphoid cells, predominantly of B‐cell lineage, or 2) mucosa‐associated lymphoid tissue (MALT), both with a propensity to involve the epiglottis and aryepiglottic folds 14 .…”

Mantle cell lymphoma of the larynx: Primary case report

“…hoarseness, dysphonia, dysphagia, stridor, cough and other systemic symptoms, such as weight loss and fever [5]. In some cases, the disease is revealed by a threatening dyspnea requiring an urgent tracheotomy as it was the case with this patient.…”

“…The age of onset for laryngeal lymphomas varies between 4 and 81 years, with the mean age of occurrence being in the seventh decade (the patient was 70 years old); the distribution between males and females is similar [5]. …”

Lymphome malin non Hodgkinien primitif du larynx: à propos d’un cas

“…L’âge médian de survenue est de 63 ans avec des extrêmes allant de 14 à 90 ans. Les données sur le sex-ratio hommes/femmes sont contradictoires [1–3]. La symptomatologie initiale habituelle comprend une dysphonie, une dysphagie, une sensation de corps étranger, un stridor ou des signes généraux, tels que la perte de poids, les sueurs nocturnes et de la fièvre.…”

“…Markou a analysé les cas de LMNH primitif de larynx publié entre 1996 et 2008, 47% d′entre eux sont situés dans la région sus-glottique, 25% sont glottiques, le reste sont soit sous-glottique ou transglottique [4]. Sur le plan macroscopique, la plupart des lymphomes du larynx se présentent sous forme d'une masse sous-muqueuse ou d'une tumeur polypoïde, ils sont lisses, non ulcérés, et blanc-grisâtres [3]. Pour affirmer le diagnostic.…”