Primary large-cell neuroendocrine carcinoma of the scrotum

Abstract

Neuroendocrine tumors (NETs) mostly develop from the neural crest cells but a few arise from neuroectoderm. They are common in the lungs and gastrointestinal tract but rare in the genitourinary tract. A 78-year-old man with no family history of malignant or hereditary diseases presented with a 3-month history of a rapidly growing asymptomatic scrotal nodule and swelling in the groin. He had a negative history of sexually transmitted disease and of trauma, fungal infection or chronic irritation in the scrotal area; there was no history of radiotherapy or exposure to chemicals or arsenic. Both the scrotal and groin lesions were excised with a minimum of 1.2 cm of normal skin. Examination of the specimen revealed a confined poorly differentiated large-cell neuroendocrine carcinoma with a metastasis to the inguinal lymph nodes. Three months after the excision we found a local recurrence. The recurrent tumor revealed tumor tissue concurrent with the primary lesion. To the best of our knowledge, there have been no previously published case reports on neuroendocrine tumor of the scrotum.

Primary Neuroendocrine Tumor of the Scrotum: An Uncommon Site for a Rare Tumor

“…CAPTEM have been known to be active in the first-line setting for advanced pancreatic neuroendocrine neoplasms. 3 meta-analysis to study safety and efficacy of treating patients with advanced NETs with CAPTEM showed the combination to be both effective and relatively safe in a variety of different malignancies. 5,6 In addition, the high objective response rates, achieved with CAPTEM makes it natural choice for patients who are heavily pretreated and "chemo resistant" until this regimen.…”

“…1 They are more commonly found in the lungs and gastrointestinal tract, but are rare in the genitourinary tract. 2,3 They are more common in women. 3 Most male genital tract NETs are prostatic small cell carcinomas or testicular carcinoids.…”

“…2,3 They are more common in women. 3 Most male genital tract NETs are prostatic small cell carcinomas or testicular carcinoids. Small cell carcinoma is extremely rare in the scrotum, penis, and penile urethra.…”

“…Small cell carcinoma is extremely rare in the scrotum, penis, and penile urethra. 3 NETs are divided into 2 groups based on clinical behavior, histology, and proliferation rate: well-differentiated (low grade to intermediate grade) and poorly differentiated (high grade) NETs. 2 We report a case of poorly differentiated NET of the scrotal skin with rapidly progressive clinical course at this rare site.…”

A Case Report of Scrotal Carcinoma and Review of the Literature

“…The published reports usually come from small, single-institution series [2, 3, 4, 5]. Among the primary scrotal cancers, the most common histologic type is squamous cell carcinoma.…”