Primary lacrimal sac diffuse large B-cell lymphoma in a child

Parikh, Deep; Rodgers, Rand; Kodsi, Sylvia R.

doi:10.1016/j.jaapos.2018.06.009

Cited by 4 publications

(7 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite isolated reports of both natural killer/T-cell lymphoma 13–15 and T-cell leukemia 16 involving the lacrimal sac, most primary and secondary lacrimal sac lymphomas are non-Hodgkin B-cell–derived neoplasms. Cases of secondary lacrimal sac lymphoma have been less commonly reported in the literature than cases of primary lacrimal sac lymphoma, 4,13–50 although in larger series it appears that secondary lacrimal sac lymphomas may in fact be more common than primary lymphomas. Determining the histologic subtype of lymphoma and whether it is primary or secondary has both prognostic and therapeutic implications.…”

Section: Discussionmentioning

confidence: 91%

Lymphoma of the Lacrimal Sac: The Massachusetts Eye and Ear Experience With a Comparison to the Previously Reported Literature

Neerukonda¹,

Stagner²,

Wolkow

2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

View full text Add to dashboard Cite

Purpose: To describe the frequency, clinical features, and histologic subtypes of biopsy proven lacrimal sac lymphomas, and to compare these results to the previously published literature. Methods: A retrospective chart review was performed at a single institution from 2004 to 2017. Pathology reports, operative notes, and patients’ medical charts were reviewed. Results: Of 566 lacrimal sacs submitted for routine histopathologic evaluation, 16 cases of lymphoma were identified. All were low-grade, non-Hodgkin B-cell lymphomas, biopsied at an average age of 71 years. Thirteen patients (81.25%) had a pre-existing lymphoma diagnosis; the average interval between the diagnosis of systemic or nonocular adnexal lymphoma and lacrimal sac lymphoma was 7.9 years (range 2–26 years; median 5.5 years). Three cases of primary lacrimal sac lymphoma were identified. Histopathology showed 3 cases (18.75%) of follicular lymphoma, 3 (18.75%) of extranodal marginal zone lymphoma, and 10 (62.5%) of chronic lymphocytic leukemia/small lymphocytic lymphoma. Primary cases presented with epiphora and nasolacrimal duct obstruction, while secondary cases predominantly manifested as dacryocystitis. All lacrimal sac neoplasms were locally responsive (without local recurrence) to chemotherapy, radiation, or both. Conclusions: Lacrimal sac lymphoma is uncommon but should be suspected among patients with known lymphoma who develop dacryocystitis. In this series, primary lacrimal sac lymphoma most often presented as a mass or nasolacrimal duct obstruction. Chronic lymphocytic leukemia/small lymphocytic lymphoma was the most commonly identified cause of secondary lacrimal sac lymphoma. Distinguishing primary from secondary lacrimal sac lymphomas is important, as the extent of disease and histopathologic subtypes differ, which may affect patient management.

show abstract

Section: Discussionmentioning

confidence: 91%

Lymphoma of the Lacrimal Sac: The Massachusetts Eye and Ear Experience With a Comparison to the Previously Reported Literature

Neerukonda¹,

Stagner²,

Wolkow

2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

View full text Add to dashboard Cite

show abstract

“…To date, only a few pediatric cases with primary NHL of LDS have been reported, including the cases of DLBCL, MALT lymphoma, and a poorly differentiated lymphoma. [5][6][7][8][9][10] Lacrimal sac tumors mostly mimic dacryocystitis, even though the differential diagnosis includes dacryocystitis, primary tumor or metastasis from systemic cancer, and nonspecific granulomatous inflammation such as Wegener's granulomatosis. Acquired dacryocystitis usually affects adults over 40 years of age, whereas congenital dacryocystitis tends to occur in infants just after birth.…”

Section: Discussionmentioning

confidence: 99%

“…To date, only a few pediatric cases with primary NHL of LDS have been reported, including the cases of DLBCL, MALT lymphoma, and a poorly differentiated lymphoma. 5–10…”

Section: Discussionmentioning

confidence: 99%

“…The knowledge of the clinical course of primary lymphoma in pediatric patients is limited, since there are only a few pediatric cases with primary LDS lymphoma reported in the literature as far as our knowledge. [5][6][7][8][9][10] Lacrimal sac tumors may present with epiphora and painless swelling of lower eyelid. They can be misdiagnosed easily as dacryocystitis, particularly in patients with involvement of the nasolacrimal duct.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Primary mucosa-associated lymphoid tissue (MALT) lymphoma of the lacrimal drainage system in two pediatric patients

Üçgül

Tarlan

Göçün

et al. 2019

European Journal of Ophthalmology

View full text Add to dashboard Cite

Primary non-Hodgkin lymphoma (NHL) of lacrimal drainage system (LDS) is quite rare in children, but it is important to expedite early diagnosis in an effort to alter possible life-threatening disease since they are usually misdiagnosed as chronic dacryocystitis. In the literature, there are few examples of tumors of LDS in children. The authors herein report two pediatric cases of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) originating from lacrimal sac in an attempt to increase the knowledge about the clinical course of NHL of LDS. Considerable care must be taken since tumors of lacrimal drainage can mimic dacryocystitis clinically and macroscopically. Two patients both attended with painless swelling in the left lacrimal sac region and epiphora of the left eye. Orbital magnetic resonance imaging showed a tumoral lesion in the left lacrimal sac region and histopathological examination of excisional biopsy specimen demonstrated MALT lymphoma in both patients. The treatment regimen comprises lacrimal sac excision within the tumor, canalicular dacryocystorhinostomy (DCR) with bicanalicular silicone intubation (BSI) combined with chemotherapy and regional radiotherapy in one case, whereas the second case received only radiotherapy after canalicular DCR with BSI. Both of them maintained clinical remission along follow-up.

show abstract

Lymphoproliferative tumors involving the lacrimal drainage system: a major review

Singh¹,

Ali

2019

Orbit

View full text Add to dashboard Cite

Primary lacrimal sac diffuse large B-cell lymphoma in a child

Cited by 4 publications

References 5 publications

Lymphoma of the Lacrimal Sac: The Massachusetts Eye and Ear Experience With a Comparison to the Previously Reported Literature

Lymphoma of the Lacrimal Sac: The Massachusetts Eye and Ear Experience With a Comparison to the Previously Reported Literature

Primary mucosa-associated lymphoid tissue (MALT) lymphoma of the lacrimal drainage system in two pediatric patients

Lymphoproliferative tumors involving the lacrimal drainage system: a major review

Contact Info

Product

Resources

About