Primary Kaposi sarcoma of the subcutaneous tissue

Pantanowitz, Liron; Mullen, John; Dezube, Bruce J.

doi:10.1186/1477-7819-6-94

Cited by 11 publications

(3 citation statements)

References 16 publications

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“…Kaposi sarcoma (KS) was first described by Moritz von Kaposi in 1872 as a low-grade mesenchymal tumor involving blood and lymphatic vessels. The mucocutaneous sites are primarily affected, typically the skin of the lower extremities, face, trunk, genitalia, and oropharyngeal mucosa; other organs are involved in the disseminated form of the disease [ 1 , 3 ]. This disease is recognized to arise as four variants, each presenting a different clinical manifestation: classic or sporadic, African or endemic, organ transplant-related or iatrogenic, and acquired immunodeficiency syndrome (AIDS)-related or epidemic [ 1 , 4 , 5 ].…”

Section: Reviewmentioning

confidence: 99%

Pulmonary involvement in Kaposi sarcoma: correlation between imaging and pathology

Gasparetto

Marchiori

Lourenço

et al. 2009

Orphanet J Rare Dis

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Kaposi sarcoma is a low-grade mesenchymal tumor involving blood and lymphatic vessels. There are four variants of this disease, each presenting a different clinical manifestation: classic or sporadic, African or endemic, organ transplant-related or iatrogenic, and AIDS-related or epidemic. Kaposi sarcoma is the most common tumor among patients with HIV infection, occurring predominantly in homosexual or bisexual men. The pulmonary involvement in Kaposi sarcoma occurs commonly in critically immunosupressed patients who commonly have had preceding mucocutaneous or digestive involvement.The etiology of Kaposi sarcoma is not precisely established; genetic, hormonal, and immune factors, as well as infectious agents, have all been implicated. There is evidence from epidemiologic, serologic, and molecular studies that Kaposi sarcoma is associated with human herpes virus type 8 infection. The disease starts as a reactive polyclonal angioproliferative response towards this virus, in which polyclonal cells change to form oligoclonal cell populations that expand and undergo malignant transformation.The diagnosis of pulmonary involvement in Kaposi sarcoma usually can be made by a combination of clinical, radiographic, and laboratory findings, together with the results of bronchoscopy and transbronchial biopsy. Chest high-resolution computed tomography scans commonly reveal peribronchovascular and interlobular septal thickening, bilateral and symmetric ill-defined nodules in a peribronchovascular distribution, fissural nodularity, mediastinal adenopathies, and pleural effusions. Correlation between the high-resolution computed tomography findings and the pathology revealed by histopathological analysis demonstrate that the areas of central peribronchovascular infiltration represent tumor growth involving the bronchovascular bundles, with nodules corresponding to proliferations of neoplastic cells into the pulmonary parenchyma. The interlobular septal thickening may represent edema or tumor infiltration, and areas of ground-glass attenuation correspond to edema and the filling of air spaces with blood. These findings are a result of the propensity of Kaposi sarcoma to grow in the peribronchial and perivascular axial interstitial spaces, often as continuous sheets of tumor tissue.In conclusion, radiological findings can play a major role in the diagnosis of pulmonary Kaposi sarcoma since characteristic patterns may be observed. The presence of these patterns in patients with AIDS is highly suggestive of Kaposi sarcoma.

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Section: Reviewmentioning

confidence: 99%

Pulmonary involvement in Kaposi sarcoma: correlation between imaging and pathology

Gasparetto

Marchiori

Lourenço

et al. 2009

Orphanet J Rare Dis

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“…[32][33][34][35][36][37][38][39][40] Em pacientes com HIV/AIDS e SK, o tumor pode manter-se estável e sem repercussões significativas ou progredir, o que ocorre aproximadamente em metade dos pacientes, os quais evoluem para a forma disseminada com envolvimento cutâneo e visceral. 22,33 Nosso estudo foi consoante com a literatura, 20,22 encontrando predominância na manifestação disseminada em ambos os cortes temporais. Entretanto, outros autores sugerem que o uso dos antirretrovirais tem diminuído a incidência das lesões mais severas em consequência da restauração imunológica promovida pelos antirretrovirais.…”

Section: Discussionunclassified

Estudo clínico de sarcoma de Kaposi em pacientes com HIV/AIDS, de 1985-1994 e 2005-2014

Maldonado

Júnior

Arnóbio

et al. 2015

Revista Hospital Universitário Pedro Ernesto

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A infecção pelo HIV é caracterizada pela coexistência da imunodeficiência, com depleção das células CD4 + e ativação crônica sistêmica do sistema imune inato e adaptativo. Pacientes com infecção pelo HIV e/ou AIDS têm o risco elevado de apresentar câncer, sendo o sarcoma de Kaposi (SK) o câncer de maior incidência e prevalência em indivíduos com HIV/AIDS. O objetivo do estudo em questão foi estabelecer a prevalência de SK em pacientes com AIDS atendidos na Disciplina de Doenças Infecciosas e Parasitárias do Hospital Universitário Pedro Ernesto, da Universidade do Estado do Rio de Janeiro em dois cortes temporais distintos (1985-1994 e 2005-2014). Foram selecionados 81 pacientes com AIDS, adultos de ambos os sexos, com diagnóstico de SK. As lesões de SK foram classificadas como localizadas ou disseminadas. Dos 81 pacientes analisados, a média de idade no momento do diagnóstico foi de 36 anos (± desvio-padrão 9,0), com mediana de 34. Quanto ao gênero, dos 81 pacientes, 76 (94%) são do sexo masculino e cinco (6%) do sexo feminino. O teste estatístico de Mann-Whitney apresentou um p-valor de 0,0029, indicando um maior número de casos para a década de 1985 a 1994. O SK na forma disseminada foi predominante em ambos os grupos. Houve uma diminuição significativa na prevalência de casos de SK desde o início da epidemia do HIV/AIDS até os dias atuais, provavelmente pelo uso dos antirretrovirais. Houve uma maior frequência da população masculina e de casos de SK na forma disseminada.

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“…La prolifération fibrovasculaire caractéristique a toutefois une évolution de nature parfois pseudo-tumorale (14). D'ailleurs, il est encore parfois utilisé le terme impropre de « sarcome de Kaposi ».…”

Section: Maladie De Kaposiunclassified

Tumeurs rares de la peau

Thomas

Poulalhon

2010

Tumeurs Malignes Rares

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Primary Kaposi sarcoma of the subcutaneous tissue

Abstract: Background: Involvement of the subcutis by Kaposi sarcoma (KS) occurs primarily when cutaneous KS lesions evolve into deep penetrating nodular tumors. Primary KS of the subcutaneous tissue is an exceptional manifestation of this low-grade vascular neoplasm.

Cited by 11 publications

References 16 publications

Pulmonary involvement in Kaposi sarcoma: correlation between imaging and pathology

Pulmonary involvement in Kaposi sarcoma: correlation between imaging and pathology

Estudo clínico de sarcoma de Kaposi em pacientes com HIV/AIDS, de 1985-1994 e 2005-2014

Tumeurs rares de la peau

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