Primary Inverted Papilloma of the Middle Ear and Mastoid

Filippis, Cosimo de; Marioni, Gino; Tregnaghi, Alberto; Marino, Filippo; Gaio, E.; Staffieri, Alberto

doi:10.1097/00129492-200207000-00027

Cited by 58 publications

(59 citation statements)

References 12 publications

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“…The major etiological factor is chronic suppurative otitis media [1][2][3][4] although irradiation and inverted papilloma of the middle ear have also been reported to be additional risk factors 1,2,5 . The relative frequency of chronic otitis media in two different studies of cancer of the middle ear cleft was reported to be 85% and 28% respectively, which strongly suggests a relationship between otitis media and aural cancer 2,3 .…”

Section: Introductionmentioning

confidence: 99%

Squamous cell carcinoma of the mastoid – a report of two cases

Lasisi

Ogunleye²,

Akang³

2006

Ghana Medical Journal

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SUMMARYMalignant tumours of the mastoid are rare, the majority being squamous cell carcinomas. We report two cases whose clinical presentation mimicked mastoid abscess with intracranial complications. The first case is a twenty year Nigerian lady who presented to the Emergency Room of the Otorhinolaryngology Department with a one month history of headache, low grade fever, left facial palsy, neck stiffness and left post-auricular swelling on a background of left chronic suppurative otitis media since childhood. An initial diagnosis of meningitis and mastoid abscess secondary to chronic suppurative otitis media was made but histology of the mastoid specimen revealed keratinizing squamous cell carcinoma, which was treated with palliative primary radiotherapy. The second case is a 45-year old man with a chronic mastoiditis and mastoid abscess that was later found to be suamous cell carcinoma of the mastoid and was managed with combination of surgery and radiotherapy. The report highlights advanced stage of the disease at presentation, and discusses the etiology and management. To the best of our knowledge, these are the first cases of this entity to be documented in Africans.

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Section: Introductionmentioning

confidence: 99%

Squamous cell carcinoma of the mastoid – a report of two cases

Lasisi

Ogunleye²,

Akang³

2006

Ghana Medical Journal

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“…Rare locations include the sphenoid sinus and frontal sinus [1][2][3][4][5]9 . In our study, the most frequent location and extension of IP was represented by involvement of both ethmoid and maxillary sinuses, in 110 cases from our series (67.90%), concurring with most authors.…”

Section: Discussionmentioning

confidence: 99%

“…This being said, tumors developing in the maxillary sinus will have to grow and extend to different close regions before expressing any discomfort to the patient, thus delaying the diagnosis. Common symptoms of IP are progressive unilateral nasal obstruction, blood mixed nasal discharge, headache, frequent throat clearing, sometimes epiphora or symptoms of sinusitis 4,5,16 . Clinical and paraclinical assessment of IP includes nasal endoscopy with anatomic macroscopic description of the tumor, imaging studies and also biopsy.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic approach of sinonasal inverted papilloma – our 15 years’ experience on 162 cases

Budu¹,

Schnaider²,

Bulescu

2015

Romanian Journal of Rhinology

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BACKGROUND. Inverted papilloma is a benign tumor of the nose and sinuses, with a high risk of recurrence and malignant degeneration. The inverted papilloma is a slow growing tumor that can be approached through an endoscopic or external approach, depending on its stage.OBJECTIVE. The aims of the study are to identify the particularities of diagnosis of the inverted papilloma, to establish the correct steps in surgical treatment of this tumor and to open the access for other steps of treatment.MATERIAL AND METHODS. The authors present their experience in managing the sinonasal inverted papilloma in a 15-year retrospective clinical study, which included 162 patients. The preoperative protocol consisted in clinical examination, nasal endoscopy, radiologic imaging (CT scan) and biopsy with histopathology results and immunohistochemistry findings. Surgical removal of the inverted papilloma was performed by endoscopic techniques, according to the stage of the tumor. We were interested in the recurrence rate of the tumor and its malignancy after a long-term follow-up.RESULTS. In our series, we included 162 patients and we had 26 (16.04%) recurrences and 12 (7.40%) malignant degenerations. All our patients were diagnosed in Krouse stages I, II and III and underwent endoscopic resection of the tumor.CONCLUSION. In order not to have any leftover tumor (the most important factor of recurrence and malignant transformation), it is mandatory to have a complete diagnosis of the inverted papilloma, a precise surgical technique and a rigorous followup. In some cases, the surgical treatment is associated with other type of treatment (antiviral, antiangiogenetic).

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“…Middle ear mucosa metaplasia by chronic inflammation may induce development of squamous papilloma. Ectopic migration of ectodermal tissue to the middle ear may also be implied in the genesis of this pathology 4,5 . Chao et al 6 showed association between HPV and cholesteatoma and middle ear papilloma without defining a causal correlation.…”

Section: Discussionmentioning

confidence: 99%

“…Middle ear papilloma pathogenesis is uncertain, and it may be associated with human papilloma virus (HPV), but there is no correlation between it and genital disease 1,3,4 .…”

Section: Introductionmentioning

confidence: 99%