Primary intraventricular Glioblastoma GBM: Case report and review of literature

Abstract

Introduction and importance: Glioblastoma multiforme (GBM) is the most common primary central nervous system tumor. The frontotemporal location is the most common location for the occurrence of GBM, however, the occurrence of this lesion in the intraventricular system is very rare and only a few cases have been reported about it in the literature. Case presentation: We present another case of primary intraventricular GBM of a 61-year-old patient with a detailed description of the clinical presentation, neuro-radiological and pathological findings, and the surgical approach to the tumor. Clinical discussion: We reviewed cases of primary intraventricular glioblastomas in the literature and concluded that it is very rare and has poor prognosis. Surgical gross debulking and the extent resection are very important factors that affect the prognosis of GBM patients. Conclusion: Intraventricular GBM is an aggressive tumor with a challenging location that is usually associated with a poor prognosis. However, our patient showed a long-term survival of 78 months. Highlights

The Significance of BRAF Mutation in the Epithelioid Glioblastoma Subtype: A Systematic Literature Review and a Case Report with a Unique Intraventricular Topography

“…Most lesions at this location, either with a true primary intraventricular origin from the ventricular walls or a paraventricular start with secondary growth into the ventricular system, have a benign nature. 9 Nevertheless, the possibility of a malignant primary tumor should be borne in mind even when it shows atypical imaging features for high-grade gliomas. 60 For example, our tumor had a well-circumscribed outline resembling an intraventricular meningioma, very similar to an intraventricular glioblastoma reported by Patnaik et al 61 E-GBMs may also mimic intra-axial low-grade tumors or cerebral metastases.…”

“…2,5,6 Although exceptional, a location within the ventricular system, where E-GBMs may resemble benign tumors, also makes a correct neuroradiological diagnosis quite challenging. [5][6][7][8][9][10][11][12][13][14] Moreover, the intraventricular location usually poses technical difficulties to achieving gross total surgical removal, a widely recognized major predictor for patient survival. 15 We present an E-GBM occupying the atrium of the left lateral ventricle, the first ever reported.…”