Primary Intraosseous Adenoid Cystic Carcinoma of the Mandible: A Comprehensive Review With Analysis of 2 Additional Cases

Hu, Hong; Liu, Yuan Yuan; Hu, Weifeng; Jiang, Meng

doi:10.1016/j.joms.2017.01.003

Cited by 8 publications

(17 citation statements)

References 46 publications

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“…The most common site involved is the posterior body and angle of mandible [2]. Pain and swelling are the most common symptoms reported followed by paraesthesia, tooth mobility and trismus [8]. Our patient was a female in the 6th decade.…”

Section: Discussionmentioning

confidence: 79%

“…PIACC generally occurs in 4th to 6th decade without gender predilection [8]. The most common site involved is the posterior body and angle of mandible [2].…”

Section: Discussionmentioning

confidence: 99%

“…Radiographically, destruction of the bone with infiltrative margins is seen in most of the cases. A few cases have reported tooth resorption, expansion of bone and involvement of inferior alveolar canal [8]. Batsakis, in 1979, proposed a diagnostic criteria for central salivary gland neoplasm: (1) radiographic evidence of osteolysis, (2) presence of intact cortical plates, (3) presence of intact mucous membrane overlying the lesion, (4) absence of primary tumor in major or minor salivary glands and (5) histological confirmation of the typical architecture and morphological features of salivary gland tumor [2].…”

Section: Discussionmentioning

confidence: 99%

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Primary Intraosseous Adenoid Cystic Carcinoma with Widespread Skeletal Metastases Showing Features of High-Grade Transformation

Savithri

Suresh

Janardhanan

et al. 2020

Head and Neck Pathol

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Malignant salivary gland carcinomas arising primarily within the jaw bones are extremely rare. The most common salivary malignancy in these locations is mucoepidermoid carcinoma followed by adenoid cystic carcinoma and adenocarcinoma. The clinical picture and imaging studies of these malignancies may be confused with odontogenic lesions which are more common in this location. Adenoid cystic carcinomas have a prolonged clinical course, tendency for perineural invasion and distant metastasis and multiple recurrences. The diagnosis of these tumors requires thorough histopathologic examination. Immunohistochemical studies may be required in cases showing solid growth pattern. High-grade transformation, earlier termed as dedifferentiation, has been observed in several salivary gland carcinomas including adenoid cystic carcinoma. These transformed tumors are reported to have an extremely poor prognosis. Here, we report a case of primary intraosseous adenoid cystic carcinoma with extensive skeletal metastases which showed a negative staining with p63 and positive staining with CD117. The tumor had a predominant solid growth pattern with areas indicative of high-grade transformation. A negative p63 staining may indicate an incomplete or focal loss of abluminal layer and this is one of the criteria for high-grade transformation in adenoid cystic carcinoma.

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Section: Discussionmentioning

confidence: 79%

“…PIACC generally occurs in 4th to 6th decade without gender predilection [8]. The most common site involved is the posterior body and angle of mandible [2].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary Intraosseous Adenoid Cystic Carcinoma with Widespread Skeletal Metastases Showing Features of High-Grade Transformation

Savithri

Suresh

Janardhanan

et al. 2020

Head and Neck Pathol

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“…The first one pertains to the pathogenesis of lesions which involves the transformation of the mucus-secreting cells in the epithelial linings of developmental odontogenic cysts. Malignant transformation also could be instigated by epithelial rests of Malassez and epithelial components of existing odontogenic tumors [ 11 ]. The last reason is related to the entrapment of salivary gland tissue in the jaw during mandibular bone development [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Primary acinic cell carcinoma of mandible, report of a case and literature review

Khoozestani

Garajei

Mahdavi

et al. 2021

International Journal of Surgery Case Reports

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Introduction and importance Acinic cell carcinoma (ACC) is a rare low-grade salivary gland malignancy that accounts for approximately 17% of all salivary gland malignancies. The most common site affected by ACC is the parotid gland followed by the submandibular glands, minor salivary glands, and sublingual glands. Also, it could hardly be observed in unusual sites such as the jaw bones. Case presentation This case is an example of a central acinic cell carcinoma in a 73-year-old man who came up with a painless gradual swelling for 15 months. Based on clinico-radio-pathologic findings, the diagnosis of a solid variant Intraosseous Acinic Cell Carcinoma was established. Subsequently, the patient underwent hemimandibulectomy and modified radical neck dissection, followed by postoperative radiotherapy. Within a six-month follow-up period, no evidence of residual tumor was found. Clinical discussion Central salivary gland carcinoma is a rare entity and intraosseous ACC is more scarcely observed. Based on our findings, a total of 17 cases of primary intraosseous ACC have been reported so far. Etiology and clinical presentations of this tumor are still vague due to its rarity. Conclusion Dentists and oral surgeons must be aware of such a rare malignant lesion when encountering a radiolucent lesion within the jaws. The early diagnosis and a complete surgical excision to achieve tumor-free surgical margins and a long-term follow-up could result in significantly improved survival rates.

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“…There have only been a small number of reports on primary mandibular neoplasm in the literature (5)(6)(7)(8)(9). There are few publications regarding fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT for primary intraosseous neoplasms of the mandible (10)(11)(12), due to the rarity of the disease.…”

Section: Introductionmentioning

confidence: 99%

Fluorodeoxyglucose positron emission tomography/CT for primary malignant intraosseous neoplasms of the mandible

Liu

2021

Mol Clin Oncol

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Primary Intraosseous Adenoid Cystic Carcinoma of the Mandible: A Comprehensive Review With Analysis of 2 Additional Cases

Cited by 8 publications

References 46 publications

Primary Intraosseous Adenoid Cystic Carcinoma with Widespread Skeletal Metastases Showing Features of High-Grade Transformation

Primary Intraosseous Adenoid Cystic Carcinoma with Widespread Skeletal Metastases Showing Features of High-Grade Transformation

Primary acinic cell carcinoma of mandible, report of a case and literature review

Fluorodeoxyglucose positron emission tomography/CT for primary malignant intraosseous neoplasms of the mandible

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