Primary intraocular marginal zone B‐cell (MALT) lymphoma

Čolović, Milica; Janković, Gradimir; Cemerikic-Martinovic, Vesna; Latković, Z; Donfrid, Milena

doi:10.1111/j.1600-0609.1998.tb00997.x

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…Heterogeneous treatment modalities were given to the patients because of the different disease stage and performance status at diagnosis. The treatment choice was dictated by the institutional medical guidelines at the time of diagnosis and the presence/absence of organ‐specific problems (24–30). Only the activity of LDH was found to significantly predict the therapeutic response.…”

Section: Discussionmentioning

confidence: 99%

More than a third of non‐gastric malt lymphomas are disseminated at diagnosis: a single center survey

Sretenović¹,

Čolović²,

Janković³

et al. 2009

European J of Haematology

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Mucosa-associated lymphoid tissue (MALT) lymphomas are extranodal B-cell tumors that generally follow an indolent course. The gastrointestinal tract is the most common site of MALT lymphoma, comprising 50% of all cases. The tissue lesions are often localized, have high therapeutic response rates with late relapses with a long overall survival (OS). The patients with non-gastric lesions may follow a different clinical course and many of them present with disseminated disease. This study reports a series of 51 patients with non-gastric MALT lymphoma. Twenty patients (39.2%) presented with disseminated disease, seven (13.7%) patients had two MALT mucosal sites involved and eight (15.7%) had involvement of three or more mucosal sites. At presentation, 17 (33.3%) patients had the lymph node and 12 (23.5%) the bone marrow involvement. Following various combinations of treatment, complete remission was achieved in 40 (81.6%), and partial remission in three of the 49 treated patients with no difference in response rates between different disease stages. Relapse occurred in 12/43 (27.9%) patients among whom eight (18.6%) recurred in the presenting organ system. Five patients (9.8%) died because of a rapid disease progression after a median follow-up of 56 months; two patients with primary lung lesions, 1 patient with secondary intestinal disease, and 2 patients suffered transformation to diffuse large B-cell lymphoma. No significant difference in survival was found between localized and disseminated disease (log rank 0.05, df = 1, P = 0.81). A patient age > or = 60 yr at diagnosis and presentation with the nodal disease were found to be statistically significant negative prognostic factors (P < 0.05). Median OS was not reached after 145 months of follow-up, with the estimated OS being 88% at 2 yr, and 78% at 5 yr.

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Section: Discussionmentioning

confidence: 99%

More than a third of non‐gastric malt lymphomas are disseminated at diagnosis: a single center survey

Sretenović¹,

Čolović²,

Janković³

et al. 2009

European J of Haematology

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Central nervous system manifestations of marginal zone B-cell lymphoma

et al. 2010

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Primary or secondary central nervous system (CNS) involvement by marginal zone B-cell lymphoma (MZBCL) is rare. A retrospective analysis of patients was done with MZBCL involving the CNS, diagnosed and treated at our institution between 2004 and 2010. We identified 10 MZBCL patients with primary (six) or secondary (four) CNS involvement. Five patients presented with primary dural lymphoma and were treated with surgical resection, whole-brain radiation, or systemic chemotherapy. Only one patient had CNS relapse 5 years later. A single patient with primary intraocular lymphoma achieved clinical remission with ocular radiotherapy and systemic chemotherapy. Four patients had ocular MZBCL within 5 years of the initial diagnosis of primary ocular adnexal MZBCL and primary splenic MZBCL. There was no evidence of local recurrence in all but one who developed systemic relapse after 3 years of follow-up. Primary or secondary CNS involvement by MZBCL display indolent clinical behavior and have a generally favorable prognosis, underlining the importance of their differentiation from aggressive lymphomas that more commonly involve the CNS.

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Dural marginal zone lymphoma with massive amyloid deposition: rare low-grade primary central nervous system B-cell lymphoma

Lehman¹,

Horoupian²,

Warnke³

et al. 2002

Journal of Neurosurgery

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The authors report the case of a 63-year-old woman who presented with a primary dural extranodal marginal zone lymphoma (MZL) associated with massive kappa light chain amyloidosis of the meninges. Extranodal MZL is a low-grade B-cell lymphoma that may show variable degrees of plasmacytic differentiation. Like solitary plasmacytoma of soft tissue, which can also be associated with amyloid, extranodal MZL generally responds well to local therapy and has a good prognosis. It is important to distinguish these entities from high-grade primary central nervous system (CNS) B-cell lymphomas and more aggressive and/or widespread, potentially amyloidogenic conditions such as multiple myeloma, lympho-plasmacytoid lymphoma, and chronic lymphocytic leukemia/small lymphocytic lymphoma. To the authors' knowledge this is the first reported case of dural MZL associated with massive meningeal amyloid deposition. Extranodal MZL is a rare low-grade primary CNS B-cell lymphoma that may be associated with amyloidosis. It should be considered in the differential diagnosis of CNS lymphoproliferative lesions and CNS amyloidosis.

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Primary intraocular marginal zone B‐cell (MALT) lymphoma

Cited by 3 publications

References 4 publications

More than a third of non‐gastric malt lymphomas are disseminated at diagnosis: a single center survey

More than a third of non‐gastric malt lymphomas are disseminated at diagnosis: a single center survey

Central nervous system manifestations of marginal zone B-cell lymphoma

Dural marginal zone lymphoma with massive amyloid deposition: rare low-grade primary central nervous system B-cell lymphoma

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