Primary Intracranial Squamous Cell Carcinoma

Murase, S.; Yamakawa, Haruki; Ohkuma, Akio; Sumi, Yasuhiko; Kajiwara, Meisetsu; Takami, Taro; Sakai, Noboru

doi:10.2176/nmc.39.49

Cited by 28 publications

(20 citation statements)

References 16 publications

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“…1,2,9,11,14) Nineteen of 37 cases of primary ovarian squamous cell carcinoma were associated with dermoid cysts. 15) However, malignant transformation of intracranial dermoid cysts, 4,8,12) intraspinal dermoid cyst, 7) or intravertebral dermoid cyst 6) are more rare.…”

Section: Discussionmentioning

confidence: 99%

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Squamous Cell Carcinoma Arising in an Intracranial Dermoid Cyst. Case Report.

Tsugu

Fukushima

Hayashi

et al. 2001

Neurol. Med. Chir.(Tokyo)

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A 47-year-old male presented with headache. Magnetic resonance imaging revealed an enhanced mass lesion in the cerebellar vermis and left cerebellar hemisphere and in the cisterna magna. Gross total removal of the tumor was performed. Histological examination demonstrated squamous cell carcinoma in the dermoid cyst. The patient subsequently received localized radiation therapy of total 55 Gy. He has been without tumor recurrence for 6 years since the surgery. We recommend local radiation therapy over 50 Gy following surgery.

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Section: Discussionmentioning

confidence: 99%

“…Primary intracranial squamous cell carcinoma is extremely rare, and usually arises in an epidermoid cyst 1,2,9,11,14) and only rarely in a dermoid cyst. 4,8,12) We report a case of intracranial squamous cell carcinoma arising in a dermoid cyst.…”

Section: Introductionmentioning

confidence: 99%

Squamous Cell Carcinoma Arising in an Intracranial Dermoid Cyst. Case Report.

Tsugu

Fukushima

Hayashi

et al. 2001

Neurol. Med. Chir.(Tokyo)

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“…Stereotactic radiation therapy following the surgery is also effective in some cases, with disease-free survival of more than 5 or 8 years 26,33) or local tumor control for 29 months 23) following stereotactic radiation therapy. However, no effective therapies for LC have been reported.…”

Section: Discussionmentioning

confidence: 99%

Malignant Transformation of an Intracranial Large Epidermoid Cyst With Leptomeningeal Carcinomatosis -Case Report-

Kano

Ikota

Kobayashi

et al. 2010

Neurol. Med. Chir.(Tokyo)

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A 64-year-old female presented with rapid onset of left ophthalmoplegia and truncal ataxia, after experiencing diplopia due to left abducens nerve palsy for a year. She had undergone surgery twice for left trigeminal neuralgia caused by a large intracranial epidermoid cyst at the age of 48 and 52 years. The intracranial epidermoid cyst grew and became predominantly enhanced by contrast medium on computed tomography (CT) and T 1 -weighted magnetic resonance (MR) imaging, which had not been observed earlier. The tumor was partially removed and the histological diagnosis was squamous cell carcinoma (SCC). Radiation therapy was administered, but she presented with paraplegia of the bilateral lower extremities and anesthesia due to spinal multiple metastases of SCC one year later. Radiation therapy was administered for the spinal lesions, but she died of multiple metastases to the cerebellum and medulla oblongata with hydrocephalus 2 years after the third surgery. Transformation of intracranial epidermoid cysts to SCC appears as predominant enhancement on CT or T 1 -weighted MR imaging with rapid deterioration of neurological features. All reported cases of malignant transformation of intracranial epithelial cysts to SCC with leptomeningeal carcinomatosis have occurred in intracranial epidermoid cysts.

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“…1,12,16 In contrast, the imaging characteristics of benign ECs show minimal peripheral enhancement as well as absence of edema and good demarcation between the lesion and parenchyma. 3,8,10 Our patient had symptoms that progressively worsened over the course of 2 months, and subsequent imaging revealed an enhancing mass in the thoracic region, specifically at the T3-4 level where the previous lesion had been located.…”

Section: 418mentioning

confidence: 98%

“…3 Malignant transformation of ECs to squamous cell carcinomas (SCCs) in the CNS is exceedingly rare and has only been described in intracranial ECs. 1,2,[5][6][7]10,12,14,15,20,23 We describe an intramedullary EC in the thoracic region that underwent malignant transformation 3 years after its removal. To our knowledge, this is the first reported case of a spinal EC undergoing malignant transformation.…”

confidence: 99%

Malignant transformation of an intramedullary epidermoid cyst in the thoracic region of the spinal cord

Somasundaram¹,

Lesser

Mott

et al. 2013

SPI

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Malignant transformation of epidermoid cysts (ECs) to squamous cell carcinomas (SCCs) in the CNS is exceedingly rare and has only been described in intracranial ECs. In this article, the authors describe a 53-year-old man with a history of a previously resected T3–4 EC, who presented with a 2-month history of progressively worsening weakness in the left side of his body. Magnetic resonance imaging revealed an enhancing mass in the T3–4 region, the exact location of the previous cyst. The mass was resected in gross-total fashion, and pathological analysis revealed an SCC. Postoperatively, the patient regained full strength in his lower extremities. After the resection, he received radiotherapy administered at an isodose of 50 Gy. To the authors' knowledge, this is the first reported case of malignant transformation of an intramedullary spinal EC in the literature.

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Primary Intracranial Squamous Cell Carcinoma

Abstract: A 50-year

Cited by 28 publications

References 16 publications

Squamous Cell Carcinoma Arising in an Intracranial Dermoid Cyst. Case Report.

Squamous Cell Carcinoma Arising in an Intracranial Dermoid Cyst. Case Report.

Malignant Transformation of an Intracranial Large Epidermoid Cyst With Leptomeningeal Carcinomatosis -Case Report-

Malignant transformation of an intramedullary epidermoid cyst in the thoracic region of the spinal cord

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