Primary Intracranial Squamous Cell Carcinoma Arising De Novo: A Case Report and Review of the Literature

Primary intracranial squamous cell carcinoma with a fatal course

“…This last possibility is extremely rare, and only eight cases, other than this, are reported in literature. [ 10 11 12 13 14 15 16 17 ] The clinical characteristics of these cases are summarized in Table 1 . Hamlat et al .…”

Intracranial Squamous Cell Carcinoma Arising From a Cerebellopontine Angle Epidermoid Cyst Remnant Four Decades After Partial Resection

“…Survival outcomes for the stereotactic radiosurgery group ± surgery or other adjuvant therapies, chemotherapy group ± surgery or other adjuvant therapies, and surgery plus two or more adjuvant modalities group were found to be statistically significant compared to the surgery alone group (21). Liu et al reviewed 72 cases and found that the mean survival of surgery alone ( n = 25) vs. surgery with post-operative radiotherapy ( n = 25) to be 6.9 and 11.9 months, respectively (22). Furthermore, the authors found a mean survival of surgery and stereotactic radiosurgery ( n = 3), chemotherapy alone or in combination with other treatments ( n = 3), and surgery and two or more adjuvant treatments ( n = 4) to be 23.3, 13.7, and 36.5 months, respectively (22).…”

“…Liu et al reviewed 72 cases and found that the mean survival of surgery alone ( n = 25) vs. surgery with post-operative radiotherapy ( n = 25) to be 6.9 and 11.9 months, respectively (22). Furthermore, the authors found a mean survival of surgery and stereotactic radiosurgery ( n = 3), chemotherapy alone or in combination with other treatments ( n = 3), and surgery and two or more adjuvant treatments ( n = 4) to be 23.3, 13.7, and 36.5 months, respectively (22). However, the authors emphasize that the only statistically significant difference in mean survival outcomes was between the surgery with post-operative radiotherapy group and surgery with stereotactic radiosurgery group ( P < 0.05) (22).…”

“…Furthermore, the authors found a mean survival of surgery and stereotactic radiosurgery ( n = 3), chemotherapy alone or in combination with other treatments ( n = 3), and surgery and two or more adjuvant treatments ( n = 4) to be 23.3, 13.7, and 36.5 months, respectively (22). However, the authors emphasize that the only statistically significant difference in mean survival outcomes was between the surgery with post-operative radiotherapy group and surgery with stereotactic radiosurgery group ( P < 0.05) (22). Kwon et al determined the median survival for patients treated with surgery alone ( n = 24) vs. surgery with radiotherapy or stereotactic radiosurgery ( n = 30) to be 5 and 35 months, respectively ( P = 0.037) (23).…”

“…We decided to pursue surgical resection followed by post-operative radiotherapy as the current literature (described in prior) reports significantly improved survival outcomes with this regimen compared to surgery alone (10, 20, 21, 23). Moreover, we specifically advocated for stereotactic radiosurgery, rather than traditional external beam radiotherapy, based upon favorable survival outcomes in the described literature with stereotactic radiosurgery (10, 21, 22). Although several retrospective studies have demonstrated clinical benefit with post-operative radiotherapy as well as a multimodal treatment approach, prospective trials are obligatory to define a standard of care for primary intracranial SCC.…”