Primary intracranial plasma cell granulomas presenting as malignant neoplasms

Puntambekar, Preeti; Santhakumar, Sunitha; Kupsky, William J.; Tselis, Alexandros; Mittal, Sandeep

doi:10.1007/s11060-011-0667-5

Cited by 14 publications

(11 citation statements)

References 43 publications

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“…Tissue sections in the present patient contained a perivascular infiltrate of lymphocytes and polyclonal plasma cells, which is characteristic of plasma cell granulomas (3,6,7). A slight predominance of κ as compared to λ light chains was noted, and this has also been found in other cases of plasma cell granuloma.…”

Section: Discussionmentioning

confidence: 49%

“…In the present study, the patient was followed until death, fourteen years following the initial diagnosis. Furthermore, the individual suffered four disease recurrences, adding to the eight reported cases of relapsing intra-axial plasma cell granuloma (3). Treatment of the recurrences consisted of two craniotomies, 3,600-cGy fractionated radiation and two courses of glucocorticoid therapy.…”

Section: Discussionmentioning

confidence: 90%

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Relapsing intracranial plasma cell granuloma: A case report

et al. 2013

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Plasma cell granuloma is a pathological entity reported in nearly every organ system; however, intracranial cases remain rare. In the current case report, we present a case of intracranial plasma cell granuloma with the longest known follow-up period in the literature. Medical follow-up over 14 years, detailing four recurrences following the patient’s initial presentation and management, is presented. The patient’s treatment course consisted of three craniotomies, 3,600-cGy fractionated radiation and two courses of glucocorticoid therapy. In addition to disease surveillance using clinical examination and imaging, this case represents the first description of the clinical utility of analyzing changes in an inflammatory blood marker, the erythrocyte sedimentation rate, which coincided with recurrence and response to therapy.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 90%

Relapsing intracranial plasma cell granuloma: A case report

et al. 2013

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“…Actually, the present case was similar to the published cases with tumorlike demyelinating lesions and accompanied by meningeal involvement which was evidently demonstrated on MR images. We speculate that the same radiologic appearance may contribute to the serviceability of image diagnosis for tumor-like demyelinating lesion [14].…”

Section: Discussionmentioning

confidence: 84%

Primary Inflammatory demyelinating pseudotumor in the left frontal lobe with meningeal involvement presenting as malignant neoplasms

Mou

Cai

et al. 2016

Chin Neurosurg Jl

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Background: Tumor-like demyelinating lesion is a rare form of IP, often indistinguishable from brain tumors on CT or MR imaging. Case presentation: We report here a case of pathologically confirmed tumor-like demyelinating lesions. The clinical manifestations, image feature and pathology of this case are also discussed together with a review of the relevant literature. Conclusion: The correct diagnosis of tumor-like demyelinating lesion mainly depends on the postsurgical histopathologic examinations. We suggest complete resection of the intracranial lesion and involved dura, followed by administration of short term oral prednisolone therapy will be good for preventing recurrence.

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“…PCG is an uncommon non-neoplastic lesion with the polyclonal proliferation of plasma cells [1]. This disorder is known to occur in numerous sites, with the lung mostly reported [2][3][4][5][6].…”

Section: Discussionmentioning

confidence: 99%

Cross-segment spinal plasma cell granuloma:a case report

Lin

Wang

Lin

et al. 2020

BMC Musculoskelet Disord

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Background Plasma cell granuloma (PCG) is a rare non-neoplastic entity, with the precise etiology remaining unclear. Vertebra-affected spinal PCG has not been reported yet. This report presented a case with cross-segment spinal PCG in thoracolumbar region. Case presentation A 32-year-old male patient presented to the authors’ hospital since his health check-up results showed osteolytic lesions in the thoracolumbar spine. He felt asymptomatic throughout the course. Radiological examination revealed destructive changes at T12 and L1 vertebrae. Whereas laboratory examination excluded malignant tumor. The results of routine incisional biopsy remained inconclusive, thereby necessitating complete excision of the lesions. Finally, the infiltration of plasma cells observed by pathological examination of the surgical specimen confirmed the diagnosis of PCG. Conclusions To the authors’ knowledge, this was the first case of cross-segment spinal PCG with osteolytic property. The possibility of PCG should be considered for the diagnosis and differential diagnosis of an osteolytic lesion in the spine. Since the etiology of PCG is unknown, the disorder was confirmed based on excluded diagnosis. Surgical resection is recommended both for the definite diagnosis and treatment of spinal PCG.

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Primary intracranial plasma cell granulomas presenting as malignant neoplasms

Cited by 14 publications

References 43 publications

Relapsing intracranial plasma cell granuloma: A case report

Relapsing intracranial plasma cell granuloma: A case report

Primary Inflammatory demyelinating pseudotumor in the left frontal lobe with meningeal involvement presenting as malignant neoplasms

Cross-segment spinal plasma cell granuloma:a case report

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