Primary Intracranial Angioleiomyoma: A Case Report and Literature Review

Fan, Chen; Pan, Yuehai; Teng, Yongliang; Pan, Xingchen; Yu, Ying

doi:10.1016/j.wneu.2020.01.239

Cited by 6 publications

(11 citation statements)

References 20 publications

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“…Tumefaction is mobile, tender and demonstrates an elevated superimposed layer of stratified squamous epithelium. Alternatively, an exophytic, nodular, reddish-purple, well circumscribed lesion of varying magnitude with unremarkable superimposed mucosa can be ] discerned [3,5]. The neoplasm manifests as a painful or painless nodule.…”

Section: Clinical Elucidationmentioning

confidence: 99%

“…Pain can be paroxysmal and is precipitated by fleeting touch, exposure to wind, cold, menses, variations in extraneous pressure or imperceptible stimuli [3,5]. Morimoto in 1973 categorized angioleiomyoma into three distinctive subtypes denominated as solid or capillary subtype which is painful, appears in • an estimated 66% neoplasms and arises within lower extremities, generally within female subjects [4].…”

Section: Clinical Elucidationmentioning

confidence: 99%

“…Pain is engendered due to localized tissue ischemia arising from contraction of blood vessels feeding the neoplasm or mediated through nerve fibres traversing tumour parenchyma. Miniature nerves fibres are observed entrapped within the tumour capsule or tumour stroma [5].…”

Section: Clinical Elucidationmentioning

confidence: 99%

“…Tumefaction can emerge as a well demarcated, homogenous nodule confined to deep-seated dermis or arise as a firm, sharply circumscribed, grey/white or brown nodule of magnitude below <2 centimetres. Cut surface is glistening, grey/ white or reddish brown on account of enlarged number of blood vessels [5,6]. On fine needle aspiration cytology, moderate or sparsely cellular smears are composed of uniform, spindle-shaped cells admixed with variable proportion of smooth muscle cells and fragments of collagenous tissue.…”

Section: Clinical Elucidationmentioning

confidence: 99%

“…On fine needle aspiration cytology, moderate or sparsely cellular smears are composed of uniform, spindle-shaped cells admixed with variable proportion of smooth muscle cells and fragments of collagenous tissue. Macrophages, mature adipose tissue cells or enlarged, ganglion-like cells are occasionally discerned [5,6]. On microscopy, tumour nodule is comprised of thickened smooth muscle fibres and vascular channels circumscribed by an attenuated fibrous tissue capsule.…”

Section: Clinical Elucidationmentioning

confidence: 99%

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The Sinewy Swirls- Angioleiomyoma

Bajaj¹,

Diagnostics²

2020

J Clin Images Med Case Rep

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Angioleiomyoma is an exceptional, benign, solitary neoplasm originating from tunica media of vascular smooth muscle. The neoplasm commonly represents as a uniform, well defined, solitary, soft, nodular, gradually progressive, bluish or purple lesion commonly beneath <2 centimetres magnitude with an absence of accompanying inflammation. Tumefaction is composed of thickened smooth muscle fibres and vascular channels with circumscribing attenuated fibrous tissue capsule. Additionally, the lesion may denominate organizing thrombus, mature adipose tissue cell aggregates and lymphocytic infiltrate. The neoplasm is immune reactive to desmin, myosin, α-smooth muscle actin, HHF35, calponin and h-caldesmon. Angioleiomyoma necessitates a segregation from angiomyolipoma, leiomyoma with bizarre nuclei, glioblastoma multiforme, arteriovenous malformation, cavernous haemangioma, angiofibroma, primary intracranial myopericytoma, glomus tumour, traumatic neuroma, eccrine spiradenoma, angiolipoma, ganglion cyst, neuroma, fibroma, lipoma, neurofibroma, neurilemmoma, salivary gland neoplasms as mucocoele, pleomorphic adenoma, vascular neoplasms as lymphangioma, haemangioma, pyogenic granuloma or dermoid cyst. Comprehensive surgical excision of the lesion with a tumour -free perimeter is an optimal treatment strategy.

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Section: Clinical Elucidationmentioning

confidence: 99%

Section: Clinical Elucidationmentioning

confidence: 99%

Section: Clinical Elucidationmentioning

confidence: 99%

Section: Clinical Elucidationmentioning

confidence: 99%

Section: Clinical Elucidationmentioning

confidence: 99%

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The Sinewy Swirls- Angioleiomyoma

Bajaj¹,

Diagnostics²

2020

J Clin Images Med Case Rep

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Intracranial angioleiomyoma: a case series of seven patients and review of the literature

Ivren,

Cherkezov,

Reuss

et al. 2024

J Neurooncol

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Purpose Angioleiomyoma, predominantly arising from the extremities, is a benign soft tissue tumor. Reports on its intracranial location are rare. We assessed clinical, radiological, and pathological features of intracranial angioleiomyoma (iALM) treated at our neurosurgical institution. Methods We consecutively enrolled all patients with neuropathologically confirmed iALM treated at a single neurosurgical institution between 2013 and 2021. Clinical and imaging data were collected, and histological tissue sections were analyzed. A review of the literature on iALM was conducted. Results Seven patients with iALM (four female) with a median age of 45 years (range: 32–76 years) were identified. In three cases, the lesion was found incidentally. In magnetic resonance imaging (MRI), all tumors were hypo- to isointense on T1-weighted, hyperintense on T2-weighted sequences, and gadolinium-enhancing. A strong FLAIR signal was seen in six patients. Surgery consisted of gross total resection in all cases without perioperative complications. Neuropathological staining was positive for smooth muscle actin (SMA) in all lesions. Mature smooth muscle cells arranged around blood vessels were typically observed. The Ki-67 index was ≤ 3%. The patients were discharged after a median of 6 days (range: 4–9 days). During a median follow-up time of 14 months (range: 4–41 months), no tumor recurrence occurred. In the current literature, 42 additional cases of iALM were identified. Conclusion Intracranial angioleiomyoma is a benign soft tissue tumor treated by gross total resection. Tumor morphology and positive staining for SMA lead to the neuropathological diagnosis.

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