Primary Intra-Osseous Liposarcoma of the Femur: A Case Report

Abstract

We report a rare case of an intra-osseous liposarcoma of the proximal femur. A 26-year-old man presented with a 6-month history of left groin pain radiating to the knee and an antalgic gait. Radiology showed a predominantly fatty lesion in the medial aspect of the femoral neck extending toward the lesser trochanter; most of the marrow in the femoral neck had been replaced without evidence of an extra-osseous mass; and the posterior cortex had been destroyed. Histological and immunohistochemical analyses of the tumour after open biopsy were indicative of highgrade liposarcomatous malignancy. After exclusion of any other primary tumour foci or metastases on regional and whole-body magnetic resonance images, the diagnosis of a high-grade intra-osseous primary liposarcoma of the proximal femur was made. The patient received 2 preoperative courses of neoadjuvant doxorubicin, cisplatin and methotrexate. After proximal femoral replacement following en bloc excision of the proximal femur, 4 more cycles of adjuvant ifosfamide and etoposide were given. At the 16-month follow-up, he remained independently ambulatory, with no local or distant recurrence. Tissue diagnosis and multimodal imaging, rather than any single radiological investigation, are important in making the diagnosis.

Pleomorphic liposarcoma of bone: a rare primary malignant bone tumour

“…Torigoe et al reported no effect of high dose ifosfamide; a change to cisplatin and doxorubicin resulted in liver toxicity and deterioration [ 32 ]. Macmull et al [ 28 ] found no effect with doxorubicin, and when chemotherapy was changed to ifosfamide and etoposide no relapse after 16 months follow up. In a further two cases treated with chemotherapy, there was no reported efficacy, both patients dying within 1.5 years of follow-up [ 19 , 20 ].…”

Primary liposarcoma of the fibular head: A rare location for a rare tumor: A case report

“…Their diagnosis is based on clinical and radiological elements and is confirmed by anatomopathology, to which we must add immunohistochemistry and molecular biology techniques, in particular the amplification of MDM2 and CDK4 [ 3 ]. The primary bone localization of liposarcomas remains rare; in fact, liposarcomas represent only less than 0.1% of primary bone cancers [ 4 , 5 ].…”

Computed Tomography and Magnetic Resonance Imaging of Bone Tumors

“…CT and MR imaging reveals predominantly fat-containing lesions but demonstrate aggressive features, including cortical erosion/destruction and an extraosseous extension of a soft tissue mass. 79…”