Primary Intra-Osseous Basaloid Squamous Cell Carcinoma of Mandible: Report of Rare Case with Proposed Diagnostic Criteria

Abstract

Basaloid squamous cell carcinoma (BSCC) is a distinctive variant of squamous cell carcinoma (SCC) characterised by nests of basaloid cells. BSCC is an aggressive and rare tumor of head and neck region; and is relatively rare in oral cavity in comparison to SCC. Although, infrequent, but primary intra-osseous SCC (PIOSCC) has been reported in the jaws. There are separate diagnostic criteria for this lesion and a classification for primary intra-osseous carcinoma has been described. No evidence was found in the published literature about primary intra-osseous BSCC (PIOBSCC). We, herein, present a case of giant osteodestructive lesion of the posterior mandible which was diagnosed as PIOBSCC with a correlation of histopathological and immunohistochemical features. As per the best of our knowledge, this is the first case of PIOBSCC of the jaw. There is no diagnostic criterion of PIOBSCC in the literature owing to the extreme rarity of this tumor. A diagnostic criterion is proposed here to make the diagnosis of this tumor easier.

Central mucoepidermoid carcinoma of the maxilla developing from a calcifying odontogenic cyst: A rare case report

“…Considering these findings, CMEC or other central malignant tumors should have been considered as a differential diagnosis even if clinical and radiographic findings lacked the features of malignancy. 19 …”

“…However, in our case report, the maxillary radiolucent lesion was accompanied by proliferative and destructive bone lesion in the hard palate and alveolar process. Considering these findings, CMEC or other central malignant tumors should have been considered as a differential diagnosis even if clinical and radiographic findings lacked the features of malignancy 19 …”

Primary Intraosseous Squamous Cell Carcinoma Involving the Jaw Bones: A Systematic Review and Update

“…Cortical bone expansion, tooth mobility, pain, and paresthesia were relatively common findings in the selected articles. However, early-stage tumors are commonly included in the differential diagnosis with benign odontogenic lesions, delaying the diagnosis and, consequently, appropriate treatment [5,19,20]. Lukandu et al [19] also pointed out that the late diagnosis of PIOSCC is frequently associated with the absence of imaging tests before exodontia procedures.…”

Overlapping tumor‐specific expression of p53, p16INK4a, and sirtuin 1 in Bowen's disease: A case report

“…[24][25][26] Recently, Bajpai et al reported an extremely rare case of intraosseous basaloid SCC in the mandible. 27 In their research, they discussed its immunohistochemical profile also using Ber-Ep4, P63, and EMA. Since basaloid SCC is an aggressive histological subtype of SCC, this study may be beneficial.…”

“…Recently, Bajpai et al reported an extremely rare case of intraosseous basaloid SCC in the mandible 27 . In their research, they discussed its immunohistochemical profile also using Ber‐Ep4, P63, and EMA.…”