Primary Intra-abdominal Malignant Fibrous Histiocytoma: A Highly Aggressive Tumor

Abstract

Primary intra-abdominal MFH is a very rare but aggressive malignancy with a high tendency of local recurrence and metastatic spread. Early detection and complete surgical excision with clear margins is the treatment of choice. In some cases, however, the tumor can exhibit a highly aggressive clinical course despite radical surgery and adjuvant therapy.

Malignant giant cell type fibrohistiocitom of the abdominal wall

“…Malignant Fibrous Histiocytoma is a sarcoma of mesenchymalorigin affecting soft tissues of the body, particularly the extremities and retroperitoneum 2 . rarely, it mayaffect intra-peritoneal organs 8,9 . Its occurrence has beenreported in almost all parts of the body including head and neck, intracranial, intra-abdominal organsand heart muscle.…”

A new complication of retained surgical gauze: development of malignant fibrous histiocytoma – report of a case with a literature review

“…Its occurrence has been reported in almost all parts of the body, particularly the extremities, trunk and retroperitoneum [2,11,12]. Rarely, it can affect intra-peritoneal organs [13-15]. Great interest and controversy have been generated concerning the pathological and oncological aspects of MFH [11,12] since the first description by O’Brien and Stout [16].…”

“…The fever of unknown origin at the patient’s presentation was probably caused by tumor necrosis and the release of inflammatory and pyrogenic factors in addition to the systemic effect of RSG. Therefore, in a patient who has a history of abdominal surgery and presents with the complaints of abdominal pain, distention and pyrexia of unknown origin, a CT scan should be made early in the examination as it can help identify and localize both the tumor and textiloma [5-8,13-15]. …”

“…The liver is the most commonly involved site of metastatic sarcomas, occurring in 64%–70% of patients [13-15]. The current treatment of choice for primary MFH is surgical resection.…”

“…The current treatment of choice for primary MFH is surgical resection. In order to improve survival in patients with MFH, in addition to complete resection of the primary tumor as well as isolated peritoneal or hepatic metastases where possible, an early multidisciplinary approach is also important [11-15]. Unfortunately, our patient had local recurrence of the tumor with liver metastases 14 months after the operation.…”