Primary intestinal T-cell and NK-cell lymphomas: a clinicopathological and molecular study from China focused on type II enteropathy-associated T-cell lymphoma and primary intestinal NK-cell lymphoma

Sun, Jian; Lü, Zhaohui; Yang, Dan; Chen, Jie

doi:10.1038/modpathol.2011.45

Cited by 73 publications

(92 citation statements)

References 20 publications

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“…This observation is consistent with a recent study of EATL in 18 Chinese patients, which also showed only type II histology [10]. In several previous studies of intestinal T-cell lymphomas in Asian patients [6][7][8][9]11,12,17,18], type II EATL was also predominantly observed, although fewer than 10 cases of apparently classical EATL were described. However, the diagnosis of classical EATL in these few cases had been queried, based on the lack of stringency in diagnosis, doubtful histologic features, and immunophenotypes that would in fact be consistent with type II EATL [10].…”

Section: Discussionsupporting

confidence: 92%

Type II enteropathy‐associated T‐cell lymphoma: A multicenter analysis from the Asia Lymphoma Study Group

et al. 2012

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Enteropathy-associated T-cell lymphoma (EATL) is a rare primary gastrointestinal T-cell lymphoma. A multicenter study from the Asia Lymphoma Study Group identified 38 EATL patients within a 19-year period. All cases were type II EATL. Men were affected twice as common as women, at a median age of 59 (23-89) years. None had a history of celiac disease. The sites of involvement were small bowel and stomach (5%), small bowel (63%), small and large bowel (16%), and large bowel (18%). Common presenting features were bowel perforation (34%), pain (32%), and obstruction (21%). Lymphomas showed monomorphic neoplastic lymphoid infiltrates that were CD3 1 (100%), CD56 1 (91%), TIA-1 1 (96%), CD4 -CD8 1 (63%), CD4 1 CD8 1 (19%), CD4 -CD8 -(16%), and CD4 1 CD8 -(3%). Epstein Barr virus was demonstrable in three cases. Despite chemotherapy and/or surgical resection, the overall response and complete response rates were poor at 46% and 38%. The median overall survival (OS) was 7 months and progression-free-survival (PFS) 1 month. Five patients underwent hematopoietic stem cell transplantation all were alive. Age and the prognostic index for peripheral T-cell lymphoma were not prognostically significant. Good performance status was associated with better OS (P 5 0.03), and response to initial treatment led to better OS and PFS (P < 0.001). Am. J. Hematol. 87:663-668, 2012. V

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Section: Discussionsupporting

confidence: 92%

Type II enteropathy‐associated T‐cell lymphoma: A multicenter analysis from the Asia Lymphoma Study Group

et al. 2012

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“…In Chinese patients with primary small intestinal lymphomas from Taiwan, perforation was a common presenting clinical feature, particularly in diffuse large-cell and immunoblastic lymphomas, estimated at 23% [71] . A further study of lymphoma in Chinese from Beijing revealed primary intestinal T-cell and NK-cell lymphomas were heterogeneous but not usually associated with celiac disease [72] . Instead, most were NK-cell type with a poor prognosis showing molecular evidence for a prior Epstein-Barr virus infection [73] .…”

Section: Malignant Causesmentioning

confidence: 98%

Spontaneous free perforation of the small intestine in adults

Freeman¹

2014

WJG

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“…In the intestine, the proportion of T-cell lineage NHLs is 12 % in Korea [8], 14.7 % in Japan [51], and 32-40.8 % in China [52,53]. PTCL, NOS is the most common subtype, followed by enteropathy-associated T-cell lymphoma (EATL) and ENKL [8,54,55].…”

Section: Peripheral T Cell Lymphoma In Asia 231mentioning

confidence: 99%

“…EATL type I was more common (66 %) than type II (34 %), and was especially frequent in Europe (79 %) [57]. In Asia, most EATL was type II, accounting for 100 % of EATL in China, 83 % in Japan, and 87.5 % in Korea [55,[58][59][60]. In a recent Asian collaborative study, patients with EATL were mostly adult males (median age 58 years, male:female ratio 2.6:1), presenting with abdominal pain (60 %), intestinal perforation (40 %), and weight loss (28 %).…”

Section: Peripheral T Cell Lymphoma In Asia 231mentioning

confidence: 99%

Peripheral T cell lymphoma in Asia

Park

2014

Int J Hematol

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Peripheral T-cell lymphomas (PTCLs) comprise a heterogeneous group of mature T-and NK-cell neoplasms, the incidence of which is higher in Asian countries than in Western countries. Although its etiology is mainly unknown, several risk factors (such as genetic factors, abnormal immunity, environmental factors, and infectious causes) have been proposed. PTCL are classified based on a combination of several parameters, including morphology, site of presentation, viral status, immunophenotype, and specific genetic alterations. Their classification is ongoing, with the emergence of new entities and refinement of existing entities because of the development of diagnostic markers and new genetic alterations. This review presents epidemiologic data for PTCL in Asia, together with recent progress in the pathology of PTCL compared with the WHO 2008 classification.Epidemiology T-and NK-cell lymphomas are uncommon: overall, they represent fewer than 25 % of all non-Hodgkin's lymphoma (NHL) [1][2][3]. The occurrence rates of various subtypes of T-and NK-cell lymphomas in Asia are significantly different from those observed in Western countries, and even among Asian countries. The incidence and distribution of T-and NK-cell lymphomas in several Asian countries is summarized in Fig. 1 and Table 1 [ [4][5][6][7][8][9][10][11][12][13][14][15].The frequencies of T-and NK-cell lymphomas seem to increase from West to East Asia. The occurrence rate of Tand NK-cell lymphomas are relatively low (\20 % of NHL) mainly in West Asia (Turkey 16.2 %, Iraq 19 %, and Kuwait 18 %) and South Asia (Pakistan 11.3 %, and India 20.2 %), but relatively high mainly in East Asia (China 32.5 %, Korea 22 %, and Japan 24.9 %) and Southeast Asia (Thailand 25 %). The proportion of T-and NK-cell lymphomas in Taiwan is very low (13.3 %) compared with that of other East Asian countries. Regarding the subtypes of T-and NK-cell lymphomas, two West (Turkey and Iraq) and one South (Pakistan) Asian countries share similar distribution patterns, presenting T lymphoblastic lymphoma (T-LBL) as the most common subtype, followed by peripheral T-cell lymphoma (PTCL) or anaplastic largecell lymphoma (ALCL). The frequency of mycosis fungoides/sezary syndrome (MF/SS) is very high in Kuwait. The distribution patterns of T-and NK-cell lymphomas in Thailand, Taiwan, and Korea are similar, whereas adult T-cell leukemia/lymphoma (ATLL) represents a high proportion of T-and NK-cell lymphomas in Japan. When ATLL is excluded, four countries (Thailand, Taiwan, Korea, and Japan) exhibit very similar patterns of subtype distribution of T-and NK-cell lymphomas. Extranodal NK/ T-cell lymphoma (ENKL) is frequent in China (48 %) and Korea (28.7 %), but is less frequent in Japan (10.4 %), as reported by a recent study performed by an international T-cell project [2]. In China, the frequency of T-or NK-cell lymphoma varies according to geographic region

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Primary intestinal T-cell and NK-cell lymphomas: a clinicopathological and molecular study from China focused on type II enteropathy-associated T-cell lymphoma and primary intestinal NK-cell lymphoma

Cited by 73 publications

References 20 publications

Type II enteropathy‐associated T‐cell lymphoma: A multicenter analysis from the Asia Lymphoma Study Group

Type II enteropathy‐associated T‐cell lymphoma: A multicenter analysis from the Asia Lymphoma Study Group

Spontaneous free perforation of the small intestine in adults

Peripheral T cell lymphoma in Asia

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