Primary Immunodeficiency in the Developing Countries

Immunodeficiency Hiding in Plain Sight

“…Multiple countries have begun forming registries to track PID in order to better understand and predict true population distribution [ 4 - 8 ]. Despite these advances, the diagnosis of many immunodeficiency syndromes of clinical significance remains difficult, particularly in the inpatient setting where continuity is limited and fragmentation of care is routine.…”

Characterization of the Anti-HLA Class I and II IgG Antibodies in Moroccan IVIg Using Regular Beads and Ibeads in Luminex Multiplex Single Antigen Immunoassay

“…When Immunoglobulin (Ig) therapy was replaced by Intravenous Immunoglobulin (IVIg) with sera derived from multiethnic population from Morocco, the IVIg was not affordable for most patients, until the Blood Transfusion and Hematology National Center and Fractionation and Biotechnologies French Laboratory (LFB-France) industry subcontracted IVIg production using plasma from Moroccan blood donors [1], which included both allo-immunized and non-alloimmunized males and females. As a result, the cost of IVIg therapy is reduced by about 66% [1].…”

“…As a result, the cost of IVIg therapy is reduced by about 66% [1]. Consequently Moroccan IVIg therapy is administered to primary deficiency, autoimmune and neurological diseases, including Guillain-Barre syndrome, for which it was found to be safer and effective alternative to standard therapies [2].…”