Primary Immunodeficiency Diseases in Egyptian Children: A Single-Center Study

Reda, Shereen M.; Afifi, Hanaa M.; Amine, Mai M.

doi:10.1007/s10875-008-9260-x

Cited by 83 publications

(85 citation statements)

References 34 publications

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“…Since many diseases of the predmoniantly antibody deficencies and other well-defined ID syndromes are autosomal recesive and they constitues together almost half of our cohort, male-to-female ratio (1.34:1) is not high in in this study. Compared to reports from other Middle East countries, the mean delay age in making diagnosis of PID in our group (18 months) was less than that reported from Egypt (29.9 months) [10] and Kuwait (27.3 months) [12], but longer than that from Oman (15.4 months) [14] and Turkey (8 months) [15].…”

Section: Discussioncontrasting

confidence: 86%

“…During the last few years, reports from communities with high rates of consanguinity indicate high rate of PID in the following communities: Saudi Arabia [9], Egypt [10], Iran [11], Kuwait [12], Morocco [13], Oman [14], Tunisia [13], Turkey [15]. With the high consanguinity rate in the Qatari population, genetic disorders and congenital birth defects were found to be relatively high for the population size of the country [5].…”

Section: Introductionmentioning

confidence: 99%

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Effects of family history and consanguinity in primary immunodeficiency diseases in children in Qatar

Ehlayel¹,

Bener²,

Laban³

2013

OJI

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Background: The high consanguinity in Middle East increases the risk of genetic diseases, including primary immunodeficiency diseases (PIDConclusions: This study indicates that family history is common in children with PID and helpful in reducing the delay age. Consanguinity among families of affected children is also high (higher than healthy population). Paternal parallel cousin marriages are the most common type of consanguinity. For a practicing physician, family history is a simple and useful tool when suspecting PID in children. Primary prevention of PID in Middle East communities should consider consanguinity reduction through public awareness and education and premarital counseling programs.

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Section: Discussioncontrasting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Effects of family history and consanguinity in primary immunodeficiency diseases in children in Qatar

Ehlayel¹,

Bener²,

Laban³

2013

OJI

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“…Antibody deficiencies constitute approximately 60-70% of PID patients in the community (23). Most clinical immunology centers have published tha date related only with selected patients followed up with a diagnosis of PID and CVID constitues the great majority of antibody deficiencies in contrast to our study (21,23,24). The European Society for Immune Deficiencies (ESID) reported that the most common PID was CVID with a rate of 21% among 13 708 recorded PID patients in the data belonging to 2011 published recently (23).…”

Section: Discussionmentioning

confidence: 62%

Profile of the patients who present to immunology outpatient clinics because of frequent infections

et al. 2014

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Aim: We aimed to determine the rate of primary immune deficiency (PID) among children presenting to our immunology outpatient clinic with a history of frequent infections and with warning signs of primary immune deficiency. Material and Methods:The files of 232 children aged between 1 and 18 years with warning signs of primary immune deficiency who were referred to our pediatric immunology outpatient clinic with a complaint of frequent infections were selected and evaluated retrospectively. Results: Thirty-six percent of the subjects were female (n=84) and 64% were male (n=148). PID was found in 72.4% (n=164). The most common diagnosis was selective IgA deficiency (26.3%, n=61). The most common diseases other than primary immune deficiency included reactive airway disease and/or atopy (34.4%, n=22), adenoid vegetation (12.3%, n=8), chronic disease (6.3%, n=4) and periodic fever, aphtous stomatitis and adenopathy (4.6%, n=3). The majortiy of the subjects (90.5%, n=210) presented with a complaint of recurrent upper respiratory tract infection. PID was found in all subjects who had bronchiectasis. The rates of the diagnoses of variable immune deficiency and Bruton agammaglubulinemia (XLA) were found to be significantly higher in the subjects who had lower respiratory tract infection, who were hospitalized because of infection and who had a history of severe infection compared to the subjects who did not have these properties (p<0.05 and p<0.01, respectively). Growth and developmental failure was found with a significantly higher rate in the patients who had a diagnosis of severe combined immune deficiency or hyper IgM compared to the other subjects (p<0.01). No difference was found in the rates of PID between the age groups, but the diagnosis of XLA increased as the age of presentation increased and this was considered an indicator which showed that patients with XLA were being diagnosed in a late period. Conclusions: It was found that the rate of diagnosis was considerably high (72.4%), when the subjects who had frequent infections were selected by the warning signs of PID. (Türk Ped Arş 2014; 49: 210-6)

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“…Brazil reported 50 cases of deficiency complement, followed by 13 reports of Argentina (Leiva et al, 2007). Like others studies, predominantly antibody deficiency was the principal PID observed in Latin America, Australia (Baumgart et al, 1997;Kirkpatrick et al, 2007), China (Zhao et al, 2006;Wang et al, 2011), Egypt (Reda et al, 2009), French (CEREDIH, 2010, Hong Kong (Lam et al, 2005), Iran (Aghamohammadi et al, 2002;Farhoudi et al, 2005;Rezaei et al, 2006), Italy (Luzi et al, 1983), Kuwait (AlHerz, 2008), Netherland (Zegers et al, 1994), Norway (Stray-Pedersen et al, 2000), Poland (Bernatowska et al, 1998), Republic of Ireland (Abuzakouk et al, 2005), Spain (Matamoros et al, 1997;Milá et al, 2001), Swiss (Ryser et al, 1998), Taiwan (Lee et al, 2011), Thailand (Benjasupattananan et al, 2009), Tunisia (Bejaoui et al, 1997) and USA (Javier et al, 2000;Stiehm, 2007), Studies in other countries reveled major number of granulocyte dysfunction in India (Verma et al, 2008), and Combined T-and B-cell Immunodeficiency in Turk (Shabestari et al, 2007).…”

Section: Latin American Group Of Immunodeficiencymentioning

confidence: 81%

Primary Immunodeficiency Diseases in Latin America: Epidemiology and Perspectives

Errante¹,

Condino‐Neto²

2012

Epidemiology Insights

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Primary Immunodeficiency Diseases in Egyptian Children: A Single-Center Study

Abstract: Primary immunodeficiency disorders are not rare in Egyptian children. The observed frequency of combined T- and B-cell immunodeficiencies in our cohort is relatively higher than other countries. It is a prerequisite to establish a national registry of primary immunodeficiency in Egypt.

Cited by 83 publications

References 34 publications

Effects of family history and consanguinity in primary immunodeficiency diseases in children in Qatar

Effects of family history and consanguinity in primary immunodeficiency diseases in children in Qatar

Profile of the patients who present to immunology outpatient clinics because of frequent infections

Primary Immunodeficiency Diseases in Latin America: Epidemiology and Perspectives

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