Primary immunodeficiency and recalcitrant chronic sinusitis: a systematic review

Mazza, Jill M.; Lin, Sandra Y.

doi:10.1002/alr.21789

Cited by 30 publications

(31 citation statements)

References 39 publications

(88 reference statements)

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“…Immunodeficiencies such as common variable immune deficiency (CVID), X-linked agamaglobulinmia (XLA) and specific antibody deficiency (SAD) may also contribute to difficult control of CRS as well, which should be taken into consideration in future study design. 82,83 …”

Section: Identification Of Crs Endotypes By Clustering Analysismentioning

confidence: 99%

Pathophysiologic mechanisms of chronic rhinosinusitis and their roles in emerging disease endotypes

Cao

Wang

Schleimer

et al. 2019

Annals of Allergy, Asthma & Immunology

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Objective: Chronic rhinosinusitis (CRS) is a heterogeneous disorder with distinct pathophysiologic mechanisms. Based on the transcription factor expression and cytokine production patterns in different types of innate lymphoid cells (ILCs), in parallel with those of adaptive CD4+ T helper (Th) cells and CD8+ cytotoxic T (Tc) cells, new perspectives on endotypes of patients are emerging around the immune response deviation into type 1 (orchestrated by ILC1s, Tc1 and Th1 cells), type 2 (characterized by ILC2s, Tc2 and Th2 cells), and type 3 (mediated by ILC3s, Tc17 and Th17 cells) responses. Additionally, cluster analysis has been applied to the endotyping of CRS in recent years, which has provided additional novel insights into the CRS pathogenesis. This article aims to review pathological mechanisms of CRS on the basis of type 1, type 2, and type 3 immune responses and how they inform us to begin to understand CRS endotypes. This article also reviews the recent cluster analysis studies of CRS endotypes. Finally, the impact of endotype on therapeutic management of CRS is summarized. Data Sources: Review of published literature. Study Selections: Relevant literature concerning CRS endotypes and the possible underlying mechanisms were obtained from a PubMed search and summarized here. Results and Conclusion: Both CRSwNP and CRSsNP are comprised of distinct endotypes with distinct deviated immune responses, pathogenic mechanisms, and different responses to medical and surgical treatment. An endotype of CRS with prominent type 2 immune responses is the most well studied endotype, and generally can benefit from treatment with steroids and specific type 2 disrupting biologics.

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Section: Identification Of Crs Endotypes By Clustering Analysismentioning

confidence: 99%

Pathophysiologic mechanisms of chronic rhinosinusitis and their roles in emerging disease endotypes

Cao

Wang

Schleimer

et al. 2019

Annals of Allergy, Asthma & Immunology

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“…Serious sinus infections (more than 2 in childhood and 4 in adulthood) within 1 year are 1 of the 10 warning signs of PID proposed by the Jeffrey Modell Foundation [14]. Chronic sinusitis is very frequent in PID patients [15], although this frequency varies with the type of study and PID, as shown in a systematic review where 10%-54% of patients with chronic sinusitis had PID [16]. We previously demonstrated that sinusitis was the most common ear, nose, and throat presentation in patients with primary antibody deficiency (PAD) [17].…”

Section: Sinusitismentioning

confidence: 99%

Infectious and Noninfectious Pulmonary Complications in Patients With Primary Immunodeficiency Disorders

Yazdani

Abolhassani

et al. 2017

J Investig Allergol Clin Immunol

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Primary immunodeficiency disorders (PIDs) are caused by 1 or more defects of the immune system. Patients are more likely to experience recurrent and/or severe infections and tend to develop a wide range of complications. Respiratory diseases are the main and initial manifestation in most cases and the most common complication. Pulmonary complications cause significant morbidity and mortality in patients with PIDs. Early diagnosis and appropriate treatment can prevent or at least slow the development of respiratory complications. Since the spectrum of pulmonary complications in PIDs is broad, we divided pulmonary complications into upper respiratory complications (eg, sinusitis, otitis media, and laryngeal angioedema) and lower respiratory complications (eg, pneumonia, bronchitis, bronchiectasis, interstitial lung diseases, organizing pneumonia, pulmonary adenopathies and malignancies, hyperreactive airway diseases, pulmonary dysgenesis, and adverse reactions to treatment). This review covers the main respiratory manifestations in patients with PIDs. Key words: Primary immunodeficiency disorders. Pulmonary complications. Upper respiratory tract. Lower respiratory tract. ResumenLas inmunodeficiencias primarias (PIDs) son enfermedades causadas por uno o más defectos del sistema inmunológico. Estos pacientes presentan con frecuencia infecciones recidivantes y/o severas así como otro tipo de complicaciones. Las patologías respiratorias son la principal y más frecuente manifestación y complicación de las PIDs. Las complicaciones de estas patologías pulmonares constituyen una de las principales causas de morbimortalidad entre los pacientes que sufren PIDs. El diagnóstico temprano y el tratamiento adecuado pueden prevenir, o al menos retrasar, la aparición de las complicaciones respiratorias en estos pacientes. Dado que el espectro de las enfermedades pulmonares es muy amplio, hemos dividido estas complicaciones entre aquellas que afectan a las vías aéreas superiores (sinusitis, otitis media y angioedema laríngeo, etc.) y las que afectan a las vías aéreas bajas (neumonía, bronquitis, bronquiectasias, enfermedades pulmonares intersticiales, neumonía organizada, adenopatías pulmonares y neoplasias, hiperreactividad bronquial, disgenesia pulmonar y las debidas a los efectos secundarios del tratamiento instaurado). Este artículo revisa las manifestaciones respiratorias que se observan más frecuentemente en los pacientes con PIDs. Palabras clave: Inmunodeficiencias primarias. Complicaciones pulmonares. Vías respiratorias altas. Vías respiratorias bajas.

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“…Его частота не велика (0,1 -0,4%), но его возникновение нередко требует повторных операций [1,2,4,8]. При выполнении органосохраняющих операций по поводу эхинококкоза печени это осложнение может возникнуть при повреждении желчных протоков, при не тщательном ушивании желчных свищей открывающихся в полость кисты, а после радикальных при недостаточно полном холестазе [2,5,6,10].…”

Section: Introductionunclassified

“…Достоверно увеличена концентрация IL-1β, IL-8, TNFα, INFγ. Провоспалительные цитокины поддерживают реакцию воспаления, усиливают интоксикационный симптом за счет стимуляции цитотокситности лимфоцитов [1,2]. IL-1β запускает и поддерживает реакции воспалительно-регуляторного каскада.…”

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The significance of the cytokine profile in the diagnosis of acute otitis media

Lukashevich¹

2018

Тенденции Развития Науки И Образования

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Тенденции развития науки и образования -45 -Показанием к назначению иммунотропной терапии у детей с рецидивирующим острым отитом может служить величина соотношения IL-1β/IL-10 равная 1,3 и менее. *** 1. Mazza J.M., Lin S.Y. Primary immunodeficiency and recalcitrant chronic sinusitis: a systematic review // Int

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Primary immunodeficiency and recalcitrant chronic sinusitis: a systematic review

Cited by 30 publications

References 39 publications

Pathophysiologic mechanisms of chronic rhinosinusitis and their roles in emerging disease endotypes

Pathophysiologic mechanisms of chronic rhinosinusitis and their roles in emerging disease endotypes

Infectious and Noninfectious Pulmonary Complications in Patients With Primary Immunodeficiency Disorders

The significance of the cytokine profile in the diagnosis of acute otitis media

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