Primary Idiopathic Polymyositis and Dermatomyositis Complicating Pregnancy

Successful Outcomes of Pregnancy Complicated with Dermatomyositis

“…11]. In particular, cases in whom the diagnosis of DM was made during gestation have been reported to have more fre quent pregnancy losses [2,11], On the other hand, preg nancy evolution and total fetal loss before the onset of DM seems to be similar to those in the general popula tion; total fetal loss is high even before the onset of disease in other connective tissue diseases [12][13][14], Pregnancy has an important modifying influence on disease activity in connective tissue diseases. The effects of pregnancy on DM have been clearly documented in 16 cases described to date [2, 3, 5-11, 15,16], In 12 cases, the disease was unaffected or ameliorated during pregnancy, in 4 the disease progressed and in 1 case, it led to maternal death.…”

“…The connective tissue disease may develop at almost any age; however, the peak incidence is bimodal, with a small peak between the ages of 10 and 14 and a larger peak around age 50 [1][2][3]. It is evident, therefore, that women in the reproductive age group are somewhat spared from the disease, and there is relatively little infor mation concerning the outcome of pregnancy in patients with DM, compared with other connective tissue diseases including rheumatoid arthritis and systemic lupus erythe matosus [2,4]. In contrast with previous reports on increased incidence of exacerbation throughout preg nancy and puerperium [5][6][7][8][9][10], the patients described below introduced 2 cases of successful outcomes of preg nancy complicated with DM.…”

Dermatomyositis and Pregnancy

“…Since the peak incidence of DM in women occurs between the ages of 40 and 60 years, there are few reports in the lit erature of DM or polymyositis (PM) complicating preg nancy [4][5][6][7][8][9][10][11][12][13][14][15][16]. As indicated in table 1, all possible preg nancy outcomes have been reported.…”

“…Reports of DM in preg nant women are few [4][5][6][7][8][9][10][11][12][13][14][15][16], but most have considered that the disease generally has an adverse effect on preg nancy. We have studied a case of DM associated with pregnancy, and we report it here together with a summary of previously documented cases.…”

Neuromuscular disorders in pregnancy

“…86 Outcome for the mother is generally good although there is one report of a maternal death after a postpartum exacerbation. 103 One patient reportedly improved after pregnancy termination at 16 weeks. 86 PM and DM are not transmitted to the fetus but may cause elevated serum creatine kinase (CK) levels in the neonate for a few months.…”