Primary hypertrophic osteoarthropathy (pachydermoperiostosis): a case report

Abstract

Hypertrophic osteoarthropathy is characterized by digital clubbing and periosteal reaction of long bones. Most cases are associated with malignancy or other conditions such as congenital heart disease, liver cirrhosis, pulmonary fibrosis, biliary atresia, and gastrointestinal polyps. We report a 19-year-old man presenting with arthritis, broadening of the fingers and clubbing of the fingers and toes for the previous 3 years. The ankles and knees were swollen. X-rays showed periosteal apposition. The search for a secondary cause remained negative. In cases of arthralgia/arthritis together with clubbed fingers, consideration must be given to hypertrophic osteoarthropathy. The primary or idiopathic form is rare and has a good prognosis.

Hypertrophic osteopathy in a dog associated with intra-thoracic lesions: a case report and a review

“…In animals, the term hypertrophic osteoarthropathy has not been used because the joints are not really involved (Montgomery, 2003;Piermattei et al, 2006); however, in human medicine, the term "osteoarthropathy" is still preferred because cases present with inflammatory arthritis (Armstrong et al, 2007;Dabir et al, 2007;Karkucak et al, 2007;Latos-Bielenska et al, 2007;Martinez-Ferrer et al, 2009;Nguyen and Hojjati, 2011).…”

“…In humans, primary hypertrophic osteoarthropathy was also reported as pachydermoperiostosis. This form is often familial and pachydermia is observed as an additional symptom besides the characteristic symptoms of hypertrophic osteoarthropathy (Karkucak et al, 2007;Latos-Bielenska et al, 2007;Martinez-Ferrer et al, 2009). In a recent study, evidence for both autosomal-dominant and autosomal-recessive forms of the disease was found (Castori et al, 2005).…”

Atherothrombotic brain infarction in a patient with pachydermoperiostosis

“…However, the association between the patient's stroke and his PDP could not be determined. Though the underlying mechanism of PDP has not been elucidated, endothelial growth factors, platelet abnormalities, or hormonal disturbances may be involved [4,5]. Further case reports of patients with PDP who experienced various vascular events like ours may clarify the association between arterial diseases and PDP.…”

Primary pachydermoperiostosis with hypertrophic gastropathy and a sliding hiatal hernia

“…Secondary PDP has been reported to occur with bronchogenic carcinoma, bronchiectasis, pulmonary fibrosis, cystic fibrosis, congenital heart diseases, ulcerative colitis, Crohn’s disease, liver cirrhosis, biliary atresia, and gastrointestinal polyps 22–25 …”