Primary hyperparathyroidism and cancer

Farr, Hollon W.; Fahey, Thomas J.; Nash, A. G.; Farr, C

doi:10.1016/s0002-9610(73)80046-7

Cited by 93 publications

(21 citation statements)

References 13 publications

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“…In addition, other work has shown that PTHrP expression by cells is stimulated by an extracellular matrix produced by bone cells (Guise et al, 1994. PTHfPTHrP receptor transcripts have an apparent widespread tissue distribution (Urena et al, 1993), and we have shown that breast cancer cells express the receptor and respond to PTH/PTHrP. There is some evidence that primary hyperparathyroidism can be associated with increased incidence of malignancies (Farr et al, 1973). A mitogenic effect of PTH on cancer cells could be one mechanism to explain this observation, but further work is required to confirm this.…”

Section: Measurement Of Intracellular Cyclic Amp Levelsmentioning

confidence: 74%

Parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor expression and mitogenic responses in human breast cancer cell lines

Birch

Carron²,

Scott³

et al. 1995

Br J Cancer

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Section: Measurement Of Intracellular Cyclic Amp Levelsmentioning

confidence: 74%

Parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor expression and mitogenic responses in human breast cancer cell lines

Birch

Carron²,

Scott³

et al. 1995

Br J Cancer

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“…Mild PHPT and cancer incidence An almost twofold increased incidence of malignant tumours has been reported in patients with PHPT compared with matched controls [Wajngot et al 1980;Farr et al 1973]. However bias may be present due to a number of factors; some patients may have endocrine tumour syndromes that have PHPT as a feature; in addition, an underlying malignancy is often a prompt for biochemical testing during which incidental PHPT might be detected, and patients with hypercalcaemia detected unexpectedly are likely to undergo detailed assessments for underlying malignancy [Gittoes and Cooper, 2010].…”

Section: Consequences Of Untreated Asymptomatic Phptmentioning

confidence: 99%

Review: New perspectives in the management of primary hyperparathyroidism

Ayuk

Cooper

Gittoes

2010

Therapeutic Advances in Endocrinology

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Primary hyperparathyroidism (PHPT) is a biochemical syndrome caused by the inappropriate or unregulated overproduction of parathyroid hormone, leading to hypercalcaemia. It was previously considered a relatively rare disorder, with clinical manifestations dominated by renal and/or bone disease. However, in modern times the diagnosis is most frequently recognized coincidentally on biochemical testing in patients evaluated for unrelated complaints. Parathyroidectomy is the only curative treatment for PHPT, with improved outcomes in symptomatic patients following this procedure. However, surgical intervention in patients with no clear clinical features remains controversial. The National Institutes for Health (NIH) have developed consensus guidelines giving specific indications for when surgery is recommended in patients with asymptomatic PHPT. This article examines the impact of treatment on asymptomatic PHPT, focusing on bone disease, neurocognitive function, quality of life, cardiovascular disease and mortality. Medical treatment options, including bisphosphonates and cinacalcet, are also discussed.

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“…The histologic Wndings in our patient and in previously published cases suggest that there are no obvious microscopic or immunohistochemical diVerences between functioning and nonfunctioning PTC. On the other hand, some of physicians before did not historically consider nonfunctioning PTC a distinct entity, partly because no immunohistochemical stains were available to help distinguish them from thyroid cancers and from neuroendocrine tumors of the neck and superior mediastinum (Altenähr and Saeger 1973;Chahinian et al 1981;Farr et al 1973). Currently, however, available immunohistochemistry techniques have made accurate diagnosis possible in most patients (Temmim et al 2008).…”

Section: Discussionmentioning

confidence: 99%