Primary human myoblasts display only minor alternative polyadenylation compared to the transformed C2C12model of muscle differentiation
Akriti Varshney,
Paul F. Harrison,
Angavai Swaminathan
et al.
Abstract:Alternative polyadenylation has been linked to multiple developmental and disease transitions. The prevailing hypothesis being that differentiated cells use longer 3’ UTRs with expended regulatory capacity whereas undifferentiated cells use shorter 3’ UTRs. Here, we describe the gene expression and alternative polyadenylation profiles of human primary myoblasts over a time course of differentiation. Contrary to expectations, only minor changes in the 3’ end choice were observed. To reconcile this finding with … Show more
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