Primary Hodgkin’s lymphoma of the caecum

Abstract

Extra-nodal Hodgkin's lymphoma (HL) represents 15% of all Hodgkin's lymphomas; the primary intestinal site accounts for 1% and with involvement of the ascending colon being rare. We present the case of a patient of 62 years of age diagnosed as having acute appendicitis. Anatomopathology on the excised appendectomy tissue indicated nodular lymphocytic predominant Hodgkin's lymphoma (NLPHL). The morphology indicated isolated L&H (lymphocytic or histiocytic) cells or in groups, surrounded by T lymphocytes, in an environment of germinal centres together with phenomena that would be interpreted as progressive transformation. Immunohistochemistry staining of the HL cells were positive for CD45, CD20, Bc16, EMA and MUM1 and negative for CD15 and CD30. No complementary treatment was administered. Following a literature search, the present case would appear to be the first of its kind.

Nodular Lymphocyte Predominant Hodgkin Lymphoma of the Ileum

“…Parikh et al have reported a case of NLPHL involving the pancreas [ 5 ], but true gastrointestinal tract involvement is exceedingly rare. Bohn-Sarmiento et al have reported a case of primary NLPHL involving the appendix in a 62-year-old male who presented with acute appendicitis [ 6 ]. More recently, Bagwan et al have described a 32-year-old male who was being evaluated for axillary lymphadenopathy when he presented with an acute abdomen and was found to have small bowel perforation associated with NLPHL in addition to a T-cell/histiocyte-rich large B-cell lymphoma-like component [ 7 ].…”

Hodgkin lymphoma involving ascending colon and mesenteric lymphnodes: A rare entity

“…[2][3][4] Hodgkin lymphoma involving the colon with or without nodal disease has been described in literature mostly as a single case report and occasionally as part of a larger series. [5,8] Our patient was treated with ABVD chemotherapy as is standard for nodal lymphoma. Histology in this case was of the mixed cellularity type, consistent with the literature, suggesting that mixed cellularity histology more commonly present as a central abdominal disease, as compared to a peripheral nodal disease.…”

Primary Hodgkin's Lymphoma of the Rectum: An Unusual Presentation

“…In the United States, there were an estimated 74.490 new cases of lymphoma in 2009; of these, 8.510 were HL. 1 Usual clinical presentation of HL involves lymph node enlargement in the neck and mediastinum and may include B symptoms (eg, fever, drenching sweats, weight loss). HL presents as extranodal disease in only 15% of patients, 2 usually at advanced stages or in association with an immunodeficiency disease.…”