Primary Herpes Simplex Pneumonia in a Neonate

Greene, Gerald R.; King, Douglas E.; Romansky, Stephen G.; Marble, Richard D.

doi:10.1001/archpedi.1983.02140310046013

Cited by 8 publications

(4 citation statements)

References 5 publications

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“…In only 1 of the 15 children could a history of prior HSV infection in the mother be obtained [14]. Only 3 of 14 previously described neonates had a vesicular rash [5,7,10]. Our patient had a erythematous rash on day 14 of life, which disappeared within 24 h. The fact, that the virus culture was positive for HSV 2 after 7 days indicates the presence of a low virus load, since HSV usually demonstrates cytopathic changes after I-2 days.…”

Section: Discussionmentioning

confidence: 63%

Case of the month: a newborn with tachypnoea and consolidation of the right lung

Karperien

Anker

Rothbarth

et al. 1996

European Journal of Pediatrics

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Section: Discussionmentioning

confidence: 63%

Case of the month: a newborn with tachypnoea and consolidation of the right lung

Karperien

Anker

Rothbarth

et al. 1996

European Journal of Pediatrics

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“…In addition, we propose a modification of the neonatal HSV infection classification by isolating HSV pneumonia as a specific pattern, similar to HSV CNS disease which is regarded as a distinct entity [5]. Thirdly, it is widely accepted that the overwhelming majority of neonatal HSV infections are caused by HSV2 [13]. However, many reports revealed that genital HSV1 is incriminated in serious cases of neonatal herpes infection [6, 14].…”

Section: Discussionmentioning

confidence: 99%

Pneumonia, an Unusual Initial Presentation of Neonatal Herpes Infection

Kouadio

Klinger

2019

Case Reports in Critical Care

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Neonatal herpes simplex virus (HSV) infection is a life-threatening infection with high morbidity and mortality rates. Neonatal herpes, most commonly due to HSV type 2, is a multi-system disease; however, initial pulmonary presentation is extremely unusual. We describe an infant presenting with progressive respiratory distress, which was the dominant clinical feature of HSV infection during the first days of life. Sepsis work-up and antibiotic treatment were immediately initiated; however, antiviral treatment was not given until the infant's death. HSV type 1 was isolated in nasopharyngeal and endotracheal aspirates. HSV pneumonia should be considered in a newborn with respiratory deterioration not compatible with common neonatal respiratory diseases.

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“…It has been described in immunosuppressed patients [14][15][16][17][18][19][20][21], in neonates who contract it in the birth canal [22], and in four autopsy series [23][24][25][26]. In those series which examined all autopsies in a given hospital, the incidence of pulmonary HSV ranged 0.002-0.01% [23,24], but in a study concentrating on burns patients alone the incidence was 10% [26].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary herpes simplex in burns patients

Byers

Ps²,

Quigley

et al. 1996

Eur Respir J

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P Pu ul lm mo on na ar ry y h he er rp pe es s s si im mp pl le ex x i in n b bu ur rn ns s p pa at ti ie en nt ts s R.J. Byers*, P.S. Hasleton + , A. Quigley + , C. Dennett* ABSTRACT: In this study we aimed to determine the incidence of herpes simplex virus (HSV) in the lungs of burns patients, and its association with the presence of adult respiratory distress syndrome (ARDS) and pneumonia. Haematoxylin and eosin (H&E), and immunohistochemical (IHC) staining for HSV was performed on lung tissue from 54 patients who had died following burn injury and from nine control cases. Polymerase chain reaction (PCR) for HSV deoxyribonucleic acid (DNA) was performed on a subset both of burns cases and controls.No viral inclusions were detected in H&E sections, but 50% of the burns cases were positive for HSV by IHC staining; no control cases were positive. Nuclear and cytoplasmic immunopositivity for HSV was seen in macrophages and epithelial lining cells. HSV was strongly associated with ARDS (p=0.007), but not with pneumonia (p=0.577). The relative risk of HSV infection was higher for cases with ARDS (2.21) than for those with pneumonia (1.26). PCR for HSV DNA was positive in three out of five burns cases, and in one out of five control cases.Immunohistochemical staining is more sensitive for the detection of herpes simplex virus than haematoxylin and eosin staining for detection of viral inclusions. Burns cases have a high incidence of pulmonary herpes simplex virus infection. Polymerase chain reaction results may not be fully representative due to problems of tissue necrosis postmortem. Pulmonary herpes simplex virus is strongly associated with adult respiratory distress syndrome and the two may be causally linked. Early detection and treatment of pulmonary herpes simplex virus in burns patients may reduce pulmonary complications and mortality.

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Primary Herpes Simplex Pneumonia in a Neonate

Cited by 8 publications

References 5 publications

Case of the month: a newborn with tachypnoea and consolidation of the right lung

Case of the month: a newborn with tachypnoea and consolidation of the right lung

Pneumonia, an Unusual Initial Presentation of Neonatal Herpes Infection

Pulmonary herpes simplex in burns patients

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