Primary hepatoma with metastasis to the mandible

Oral Metastatic Cancers From Hepatocellular Carcinoma

“…3,5 But also a new onset or exacerbated hypertension may serve, as in our case, as a useful (and often early) diagnostic marker for HUS. This observation is also supported by findings of Humphreys et al 2 Thus, a severe (and often difficult to control) hypertension under gemcitabine treatment should always be taken seriously and a HUS must be ruled out by laboratory analysis.…”

“…1 HCC usually metastasizes to the lungs, skeleton, adrenal glands, and regional lymph nodes. 2 Metastases from HCC to the oral cavity, first described in 1957, are rare, [3][4][5] with the sites reported only in isolated case reports. Hematogenous dissemination to the oral region is the presumed mechanism of spread.…”

Metastasis of Hepatocellular Carcinoma into the Mandible with Radiographic Findings Mimicking a Radicular Cyst: A Case Report

“…Radiographically, all reported cases of HCC metastasis to the mandible showed findings suspicious of tumor, such as tumor mass formation in the bone (10-14, 17-19, 21, 23, 24), osteolytic lesions (14,16,20,22), and ill-defined borders (3,10,11,15). The present case was quite different from these reported patients in that (1) the site of metastasis was the apex of #18 and (2) the margin of the lesion was clearly defined in x-rays.…”

“…However, HCC metastasis to the mandible is very rare. Since Dick et al (10) first reported a case of HCC metastasis to the mandible in 1957, approximately 50 cases have been documented in the literature to our knowledge (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). Patients ranged from 25 to 88 years, with a mean age of 63.9 years; 47 were male, and 2 were female.…”

Rare Metastatic Lesion Affecting the Mouth: Case Report and Review

“…Chronic infection with hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infection are the main risk factors for the development of this cancer [23]. Extra-hepatic metastasis is a fairly common occurrence, affecting more than 50% of patients frequently in the lungs, abdominal lymph nodes, diaphragm and bone [4]. Metastases in the oral cavity are rare and, when they occur the most common primary site is lung carcinoma, followed by breast carcinoma and renal cell carcinoma.…”