Primary Hepatic Neuroendocrine Carcinoma with Thrombocytopenia Due to Diffuse Bone Marrow and Splenic Infiltration: An Autopsy Case

Nakano, Shogo; Minaga, Kosuke; Tani, Yasuhiro; Tonomura, Kohei; Hanawa, Yusuke; Morimura, Hiroki; Terashita, Tomoko; Matsumoto, Hisakazu; Iwagami, Hiroyoshi; Nakatani, Yasuki; Akamatsu, Takuji; Uenoyama, Yoshito; Maeda, Chikara; Ôno, Kazuo; Watanabe, Tomohiro; Yamashita, Yoshihisa

doi:10.2169/internalmedicine.9465-22

Cited by 2 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bone marrow metastasis of NENs is extremely rare. Few studies on this topic have been published since 2000 and most of them are case reports[ 4 - 14 ]. We report a case of bone marrow metastatic NEC accompanied by bone marrow necrosis (BMN) and secondary myelofibrosis (MF).…”

Section: Introductionmentioning

confidence: 99%

Bone marrow metastatic neuroendocrine carcinoma with unknown primary site: A case report and review of the literature

Shi¹,

Deng²,

Jin³

2022

World J Clin Cases

View full text Add to dashboard Cite

BACKGROUND Metastatic neuroendocrine carcinoma (NEC) of bone marrow is uncommon. Here, we report a case of bone marrow metastatic NEC with an unknown primary site. CASE SUMMARY A 73-year-old Chinese woman was admitted to our hospital because marked chest distress and asthma lasting 1 d on March 18, 2018. She was initially diagnosed with pulmonary infection, cardiac insufficiency, thrombocytopenia and severe anemia. Following treatment with antibiotic therapy, diuresis and blood transfusion, the patient’s symptoms greatly improved. After bone marrow examinations, the patient was diagnosed with bone marrow metastatic NEC, bone marrow necrosis (BMN) and secondary myelofibrosis (MF). Further imaging workup did not show the primary tumor, we presumed that the primary site might regress spontaneously or merely be unexplored due to lack of positron emission tomography with gallium peptide. Everolimus (10 mg/d) was added to the treatment and the best supportive and symptomatic therapies were also administered. Unfortunately, the patient’s condition continued to deteriorate and she died on May 15, 2018. CONCLUSION Bone marrow invasion of NEC is rare and our patient who suffered from bone marrow metastatic NEC as well as secondary BMN and MF had an extremely poor prognosis. Bone marrow biopsy plays an important role in the diagnosis of solid tumors invading bone marrow.

show abstract

Section: Introductionmentioning

confidence: 99%