Primary Hepatic Lymphoma

Zentar, Aziz; Tarchouli, Mohamed; Elkaoui, Hakim; Belhamidi, Mohamed Said; Ratbi, Moulay Brahim; Bouchentouf, Sidi Mohammed; Ali, Abdelmounaim Ait; Bourazza, Ahmed; Sair, Khalid

doi:10.1007/s12029-013-9505-7

Cited by 14 publications

(11 citation statements)

References 15 publications

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“…A primary HML has been reported to be a very rare malignancy, representing 0.41-1% of extra-nodal lymphomas [14][15][16] . On the contrary, it is well known that ML shows frequent invasion, as it has been reported in approximately 50-60% of autopsy cases with that tumor [16,17] .…”

Section: Discussionmentioning

confidence: 99%

Abdominal Ultrasound Findings of Tumor-Forming Hepatic Malignant Lymphoma

Kitahata

Hiraoka²,

Kudo³

et al. 2017

Dig Dis

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Aim/Background: Evaluations of abdominal ultrasonography (US) findings of primary and secondary tumor-forming hepatic malignant lymphoma (HML) have not been adequately reported. In this study, we elucidated US and contrast-enhanced US (CEUS) findings in patients with HML. Materials/Methods: From January 2006 to March 2017, 25 patients with HML were enrolled (primary 7, secondary 18), each of whom was diagnosed pathologically. They were divided into 2 groups based on tumor diameter (cutoff, 30 mm). US imaging findings were retrospectively analyzed. Results: All tumors in patients with a small HML (<30 mm in diameter, small group, n = 14) were revealed as homogeneous hypo-echoic type (100%), with penetrating sign observed in only 1 patient. Tumors in 11 patients in the small group, examined with CEUS, showed homogeneous enhancement in the early vascular phase (91%) and a washout pattern in the portal phase (100%), and they were revealed as defective in the post-vascular phase (100%). In the large group (≥30 mm; n = 11), tumors were revealed as a heterogeneous hypo-echoic lesion in 10 (91%) and penetrating sign was observed in 8 (73%). Dilatation of the distal intrahepatic bile duct by the tumor was observed in 4 patients in the large group. In 7 large group patients examined with CEUS, imaging findings in the early vascular phase varied, with 5 (71%) showing a washout pattern in the portal phase and 5 (71%) revealed as defective in the post-vascular phase. Conclusion: We found that US imaging features of HML differ depending on the tumor diameter.

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Section: Discussionmentioning

confidence: 99%

Abdominal Ultrasound Findings of Tumor-Forming Hepatic Malignant Lymphoma

Kitahata

Hiraoka²,

Kudo³

et al. 2017

Dig Dis

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“…Chemotherapy with CHOP (cyclophosphamide, hydroxydaunorubicin, oncovin, prednisone)-based regimens is generally the gold standard [16], [17]. The role of surgery is not fully clarified, but there are reports that liver resection followed by adjuvant chemotherapy and/or radiation results in better prognosis [16], [18]. However, approximately 55% of MTX-LPD patients have been reported to improve following the withdrawal of MTX, without additional antitumor therapy [15].…”

Section: Discussionmentioning

confidence: 99%

Methotrexate-associated primary hepatic malignant lymphoma following hepatectomy: A case report

Takei

Abe

Amano

et al. 2017

International Journal of Surgery Case Reports

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“…Other clinical complaints are also non-specific, including nausea with vomiting, early satiety, weight loss, fatigue, difficulty in ambulation, limb weakness, and jaundice, often of short duration. 4,[13][14][15][16][17] Our case had an unusual presentation with bilateral lower limb weakness and low-grade fever. Physical examination may disclose hepatomegaly, palpable liver, and leg edema.…”

Section: Discussionmentioning

confidence: 99%

“… 18 , 19 Laboratory data may reveal elevated LDH and normal tumor marker levels. 4 , 13 , 15 – 17 Furthermore, imaging findings in PHL are also non-specific. Solitary or multiple lesions and diffuse liver infiltration lesions mimicking metastatic carcinoma have been reported.…”

Section: Discussionmentioning

confidence: 99%

An unusual case of primary hepatic lymphoma with dramatic but unsustained response to bendamustine plus rituximab and literature review

Liao

Chen

et al. 2017

SAGE Open Medical Case Reports

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Objectives:Primary hepatic lymphoma is an uncommon cause of hepatic space-occupying lesions.Methods:We describe the case of a 73-year-old man with primary hepatic lymphoma, who presented with a low-grade fever and lower limb weakness which had progressed in the past 2 months.Results:Abdominal ultrasound and computed tomography showed multiple small hepatic tumors. Echo-guided biopsy of the hepatic tumor demonstrated primary hepatic diffuse large B cell lymphoma. Moreover, bone marrow was uninvolved, but the bone marrow smear disclosed hemophagocytosis, which is uncommon in diffuse large B cell lymphoma. Chemotherapy with bendamustine and rituximab treatment was initiated with a dramatic response: hepatic tumors markedly shrank in size shown by follow-up computed tomography and the patient returned to his normal life. Nevertheless, the response was sustained for only 8 months. Finally, the disease resisted further chemotherapy and this patient died of a severe Klebsiella pneumoniae infection.Conclusion:Chemotherapy with bendamustine and rituximab has shown a dramatic, but not durable, response in the present case with old age and multiple comorbidities.

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Primary Hepatic Lymphoma

Cited by 14 publications

References 15 publications

Abdominal Ultrasound Findings of Tumor-Forming Hepatic Malignant Lymphoma

Abdominal Ultrasound Findings of Tumor-Forming Hepatic Malignant Lymphoma

Methotrexate-associated primary hepatic malignant lymphoma following hepatectomy: A case report

An unusual case of primary hepatic lymphoma with dramatic but unsustained response to bendamustine plus rituximab and literature review

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