Primary hepatic leiomyosarcoma in a patient with autosomal dominant polycystic kidney disease

Iida, Takashi; Maeda, Takuya; Amari, Yoshifumi; Yurugi, Takatomi; Tsukamoto, Yoshitane; Nakajima, Fumitaka

doi:10.1007/s13730-017-0247-4

Cited by 11 publications

(15 citation statements)

References 19 publications

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“…It is a malignant tumor that arises from smooth muscle cells (4, 8, 10-13, 15, 17, 19, 21, 22, 26, 28, 29, 31-33, 36-38, 40). Potential origins of this tumor in the liver are the smooth muscle cells in the round ligament (29,31,37,38), the intrahepatic blood vessels and the intrahepatic bile ducts (15,17,22,26,29,31,32,37,38,40). There is no apparent sex predilection, since there have been reported 23 (46%) cases of male patients ( 25,27,28,31,36,[38][39][40].…”

Section: Discussionmentioning

confidence: 99%

“…Concerning the clinical image of primary hepatic leiomyosarcomas, they are often asymptomatic (21,25,30) or their symptoms are non-specific (4, 8, 10-12, 14, 16, 17, 19, 21, 23, 27-29, 31, 32, 34, 37, 38, 40). Abdominal pain or discomfort (4, 8, 11, 12, 14, 16, 17, 19, 22, 23, 27-29, 34, 37, 38), a palpable mass (4,19,22,28,29,38), fever (17,23,28,31,32,40), jaundice (39), anorexia (10,12,27,28,32), nausea or vomiting (31,34) and weight loss (4,8,10,12,14,16,19,28,32,37) are among the reported manifestations. A case with acute bleeding has also been reported (24).…”

Section: Discussionmentioning

confidence: 99%

“…Ultrasonography usually shows a hypoechoic mass (15,17,19,29,30,33,37) or a mass with heterogeneous echogenicity (17,22,27,30,31,37). Computed tomography usually reveals a hypodense (12, 17, 19, 21, 23, 27-33, 37, 39) and often heterogeneous mass (17,21,23,31,34) with inhomogeneous and often peripheral enhancement after administration of intravenous contrast (15,17,19,23,(27)(28)(29)(30)(31)(32)(33)40), which may show regions of cystic degeneration (27,28,31,32). Magnetic resonance imaging displays on the other hand a usually heterogeneous mass that is hypointense in T1-weighted images and hyperintense in T2-weighted images (16,19,21,37,39,40).…”

Section: Discussionmentioning

confidence: 99%

“…Computed tomography usually reveals a hypodense (12, 17, 19, 21, 23, 27-33, 37, 39) and often heterogeneous mass (17,21,23,31,34) with inhomogeneous and often peripheral enhancement after administration of intravenous contrast (15,17,19,23,(27)(28)(29)(30)(31)(32)(33)40), which may show regions of cystic degeneration (27,28,31,32). Magnetic resonance imaging displays on the other hand a usually heterogeneous mass that is hypointense in T1-weighted images and hyperintense in T2-weighted images (16,19,21,37,39,40). Histological examination of primary hepatic leiomyosarcomas shows spindle-shaped cells with fascicular arrangement (4, 8, 10-12, 15-17, 19, 21, 22, 26-34, 36-38, 40).…”

Section: Discussionmentioning

confidence: 99%

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Primary Hepatic Leiomyosarcoma: a Case Report and Review of the Literature

Feretis

Kostakis

Damaskos

et al. 2018

Acta Med. (Hradec Kralove, Czech Repub.)

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A B ST R AC T Background/Aim: Primary hepatic leiomyosarcoma is an extremely rare type of liver sarcoma with relatively poor prognosis, with about 50 cases having been reported in the literature. Potential origins of this tumor in the liver are the smooth muscle cells in the round ligament, intrahepatic blood vessels and intrahepatic bile ducts. There is no apparent sex predilection and there is a wide age range. The clinical presentation is not specific and the diagnosis depends on the expression of markers such as smooth muscle actin, desmin and vimentin by tumor cells. Patients and Methods: Herein, we present a case of a bulky primary hepatic leiomyosarcoma in a 68-year-old female patient. The patient underwent resection of the exophytic mass en block with the hepatic segments III and IVB. Conclusion: Surgical resection is the most effective among the treatment options. K E Y WO R D S hepatic; liver; leiomyosarcoma, primary

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Primary Hepatic Leiomyosarcoma: a Case Report and Review of the Literature

Feretis

Kostakis

Damaskos

et al. 2018

Acta Med. (Hradec Kralove, Czech Repub.)

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“…Liver resection on a polycystic liver disease could be challenging. Liver resections for hepatic tumors developed on a polycystic liver disease were previously described in only few patients with haemangiomas (9), primary leiomyosarcomas (10), and angiomyxomas (11). Furthermore, other few cases of non-resected liver tumors developed on polycystic liver disease were also described in patients with neuroendocrine tumours (12) or Schneiderian metastatic carcinomas (13).…”

Section: Discussion Discussionmentioning

confidence: 99%

Liver Resection for Metastasis of Rectal Cancer Origin in a Polycystic Liver

Pavel¹,

Procop²,

P³

et al. 2018

SGO

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Liver metastases of colorectal origin are a common pathology, and the most frequent indication for liver resection. Associated chronic liver pathology may potentially increase the difficulty of a liver resection. Hereby, it is presented the case of a 67-year-old woman with a liver metastasis of rectal cancer origin with concomitant polycystic liver disease. An atypical liver resection was performed with intraoperative ultrasound guidance. Liver tumors developed on a polycystic liver are rarely described. For these particular cases, the diagnosis is challenging, but liver resection can be safely performed with the intraoperative ultrasound guidance.

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