Primary Hepatic Leiomyosarcoma

Holloway, H.; Walsh, Caitriona Barry; Thomas, Renu; Fielding, J. W. L.

doi:10.1097/00004836-199609000-00014

Cited by 17 publications

(15 citation statements)

References 10 publications

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“…Extensive workup should be done with endoscopies, small bowel follow-through, abdominal, and chest imaging, and PET scan to rule out extra hepatic primary. Primary leiomyosarcoma of the liver arises from smooth muscle cells in the wall of intrahepatic blood vessels or biliary ducts [5, 6]. Potential etiological associations reported in the literature include EBV, HIV/AIDS, and history of immunosuppression.…”

Section: Discussionmentioning

confidence: 99%

A Rare Occurrence of Primary Hepatic Leiomyosarcoma Associated with Epstein Barr Virus Infection in an AIDs Patient

Chelimilla

Badipatla²,

Ihimoyan³

et al. 2013

Case Reports in Gastrointestinal Medicine

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Primary hepatic leiomyosarcoma is exceedingly rare accounting for less than 1% of the hepatic tumors. Close to 45 cases have been reported in the English literature. Presentation is usually nonspecific and diagnosis is often delayed until tumors reach a large size. This leads to a dismal prognosis. The tumors are not yet fully understood, hence the standard of care is not well defined. Curative resection remains the mainstay of management. Close association of Epstein Barr virus (EBV) induced soft tissue sarcomas is proven, especially in the presence of immunosuppression encountered in HIV/AIDS patients and in posttransplant patients. We herein present a case report of a 54-year-old man diagnosed to have HIV/AIDS and EBV infection admitted to our hospital with complaints of intractable hiccups for more than a week. Extensive workup revealed primary leiomyosarcoma of the liver.

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Section: Discussionmentioning

confidence: 99%

A Rare Occurrence of Primary Hepatic Leiomyosarcoma Associated with Epstein Barr Virus Infection in an AIDs Patient

Chelimilla

Badipatla²,

Ihimoyan³

et al. 2013

Case Reports in Gastrointestinal Medicine

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“…Hepatic leiomyosarcoma may arise from intrahepatic vascular structures [4] , bile ducts [5] or ligamentum teres [6] . Tumors arising from the hepatic veins may develop Budd-Chiari syndrome and have a worse prognosis with tumors arising from the ligamentum teres having a better prognosis due to its increased resectability [6] .…”

Section: Discussionmentioning

confidence: 99%

“…The median age of diagnosis is 58 years with sporadic occurrence of the tumor in the younger age group [12] . Primary hepatic leiomyosarcoma presents a clinical dilemma: not only are they unusual and rare with less than 50 cases described in the literature, but they are often asymptomatic until they become large, and even then they produce nonspecific symptoms [5][6][7][8] . Patients may be afflicted with a wide spectrum of symptoms, such as abdominal pain, weight loss, anorexia, vomiting, jaundice and rarely acute intraabdominal bleeding secondary to tumor rupture [13] .…”

Section: Discussionmentioning

confidence: 99%

“…Died at 20 mo Masur (1975) [12] 62 F Chemotherapy Autopsy diagnosis Masur (1975) [12] 66 F Lobectomy Died at 49 mo Yoshikawa (1977) [12] 58 F Wedge resection Died at 11 d postoperatively Bloustein (1978) [12] 12 F Trisegmentectomy, chemotherapy NED at 6 yr O'Leary (1982) [12] 69 M Alive at 24 mo Chen (1983) [12] 78 M Chemotherapy, radiation Died at 10 mo Maki (1987) [12] 86 F Surgery NED at 5 mo Paraskevopoulos (1991) [12] 62 M Lobectomy NED at 5 mo Baur (1993) [12] 69 F Surgery Recurrence after 10 yr Holloway (1996) [5] 63 M Conservative Soyer (1996) [12] 67 F Surgery Sato (2000) [12] 62 F Autopsy diagnosis Tsuji (2000) [11] 68 M Hepatitis C Autopsy diagnosis Lordanidis (2002) [12] 25 M Surgery Died at 3 mo Fujita (2002) [9] 33 F Prior renal transplant Right posterior segmentectomy NED at 24 mo Lee (2002) [13] 64 F Right lobectomy + wedge resection of left lobe NED at 24 mo Almogy (2004) [12] 58 F Surgery + chemotherapy Died at 4 mo 63 F Surgery + chemotherapy Died at 12 mo Watanabe (2008) [12] 63…”

Section: Discussionmentioning

confidence: 99%

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Primary hepatic leiomyosarcoma: Case report and literature review

Shivathirthan

Kita²,

Iso³

et al. 2011

WJGO

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Primary hepatic leiomyosarcoma are rare tumors with less than 30 cases reported in the English literature. Non specific presentations and often diagnosis delayed until they reach a large size, is the norm with therapy leading to an often dismal prognosis. A 67-year-old man presented complaining of abdominal pain and a palpable abdominal mass since Jan 2010. Abdominal ultrasonography and abdominal computed tomography revealed a large tumor in the left lobe of the liver. Surgical exploration was undertaken and an extended left hepatectomy with extension onto the dorsal part of segment 8 preserving the MHV with partial resection of segment 6 was undertaken. The weight of the resected specimen was 1300 g of the left lobectomy specimen and 8 g of the segment 6 partial resection specimen. The pathology report confirmed the diagnosis of leiomyosarcoma. On immunohistochemistry, the tumor cells were positive for smooth muscle actin stain. The patient is on regular follow up and is currently 9 mo post resection with no evidence of recurrence. We report the case of a resected primary hepatic leiomyosarcoma and emphasize the need for a global database for these rare tumors to promote a better and broader understanding of this less understood subject.

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“…1,2 However, there are an increasing number of reports of this tumor in younger human immunodeficiency virus (HIV)-infected patients 3,4 and immunosuppressed transplant patients. 5,6 Recently, the occurrence of Epstein-Barr virus (EBV)-associated smooth muscle tumors, including leiomyosarcoma, in immunocompromised patients was reported, particularly in children and adolescents.…”

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confidence: 99%

Primary Hepatic Leiomyosarcoma in a Woman After Renal Transplantation: Report of a Case

et al. 2002

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In contrast to malignant lymphomas or skin cancer, smooth muscle tumors including leiomyosarcoma are rarely associated with transplant recipients. We herein present a 33-year-old woman with end-stage renal disease who received a transplant at 27 years of age. Four years after the transplantation, at age 31, she underwent a mastectomy because of primary right breast cancer, which was found to be a 5-mm-sized mucinous carcinoma with no regional lymph node metastasis. Six years after the transplantation, a liver tumor was unexpectedly discovered. An explorative laparotomy revealed a well-encapsulated tumor occupying the posterior portion of the right lobe of the liver. The patient underwent a posterior segmentectomy. Histologically, the tumor possessed intermingling fascicles of spindle cells with eosinophilic cytoplasm and elongated nuclei. Based on an immunohistochemical examination, the tumor cells were positive for the muscle-associated antibody. In addition, RNA probes for Epstein-Barr virus were negative based on in situ hybridization. The histologic, immunohistochemical findings were considered to be diagnostic for leiomyosarcoma, which is a low-grade malignancy. Two years after surgery, the patient is doing well with no recurrence of liver tumors or breast cancer.

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Primary Hepatic Leiomyosarcoma

Abstract: Hepatomegaly was noted in a 63-year-old man who presented with an exacerbation of chronic pulmonary disease. A diagnosis of hepatic leiomyosarcoma was made by fine needle aspiration biopsy. Intensive investigations failed to reveal a primary source. The patient was treated conservatively.

Cited by 17 publications

References 10 publications

A Rare Occurrence of Primary Hepatic Leiomyosarcoma Associated with Epstein Barr Virus Infection in an AIDs Patient

A Rare Occurrence of Primary Hepatic Leiomyosarcoma Associated with Epstein Barr Virus Infection in an AIDs Patient

Primary hepatic leiomyosarcoma: Case report and literature review

Primary Hepatic Leiomyosarcoma in a Woman After Renal Transplantation: Report of a Case

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