Primary Hepatic Circumscribed Burkitt's Lymphoma that Developed after Acute Hepatitis B : Report of a Case with a Review of the Literature

Sekiguchi, Y.; Yoshikawa, Hitomi; Shimada, Asami; Imai, Hidenori; Wakabayashi, Mutsumi; Sugimoto, Keiji; Nakamura, Noriko; Sawada, Tomohiro; Takeuchi, Kengo; Ohta, Yasunori; Komatsu, Norio; Noguchi, Masaaki

doi:10.3960/jslrt.53.167

Cited by 10 publications

(5 citation statements)

References 18 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9 Proposed etiological factors include preexisting chronic hepatitis, cirrhosis, Ebstein Barr Virus (EBV), Hepatitis B and C and those on immunosuppressives. [10][11][12][13][14] Radiologically predominantly hypodense solitary lesion is the most common presentation, although multiple lesions and diffuse infilterative forms with variable enhancement patterns are known. 2 In the present case report the tumor presented as a solitary lesion with faint enhancement and FNAC suggestive of hepatocellular carcinoma, that led to the misdiagnosis.…”

Section: Discussionmentioning

confidence: 99%

Primary hepatic lymphoma mimicking hepatocellular carcinoma: case report and review of literature

et al. 2019

View full text Add to dashboard Cite

Primary hepatic lymphoma (PHL) is a very rare malignancy presenting with non specific symptoms leading to late diagnosis. Due to its ability to masquerade other liver tumors, misdiagnosis is common. Here we present a case of a 52 years old man who presented with an incidentally detected SOL in liver with features of atypical hepatocellular carcinoma on imaging and fine needle aspiration cytology. He underwent a left hepatectomy and the final histology was a surprise in the form of hepatic lymphoma. He underwent appropriate chemotherapy post surgery and is asymptomatic at follow up.

show abstract

Section: Discussionmentioning

confidence: 99%

Primary hepatic lymphoma mimicking hepatocellular carcinoma: case report and review of literature

et al. 2019

View full text Add to dashboard Cite

show abstract

“…[ 2 , 4 , 5 ] As regarding the sporadic BL, although the gastro-intestinal tract is the commonest site, hepatic BL was also reported to occur no later than 1 year after hepatitis B or C virus infection. [ 2 , 4 ] Helicobacter pylori infection, celiac disease, and post-transplant status were associated with extranodal lymphomas and even BL [ 6 , 7 ] but no papers about concurrent streptococcal infection-related cardiac disorders have been published to date. It is important to mention that associated-eradication of H pylori to the chemotherapic regimens increased the rate of complete remission in patients with gastric BL.…”

Section: Discussionmentioning

confidence: 99%

“…[ 3 ] The extranodal BL especially occurs in gastrointestinal tract (2 quarters of the cases) and head and neck areas (1 quarter); bone marrow, genito-urinary tract, bones, central nervous system, and liver were also reported to be involved. [ 3 , 4 ] In more than 60% of the cases, the overall survival is below 5 months; the negative prognostic factors are bone marrow and central nervous system involvement [ 3 ] as well as delayed diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Gastric Burkitt lymphoma

Gurzu

Bara

Turcu³

et al. 2017

Medicine

View full text Add to dashboard Cite

Rationale:Burkitt lymphoma (BL) is an endemic tumor in Africa but rare sporadic cases are diagnosed in Europe.Patient concerns:A 60-year-old woman was hospitalized with fulminant hematemesis and a history of recurring melena.Diagnoses:The upper gastrointestinal endoscopy revealed a tumor of the antrum.Interventions:Emergency gastrectomy was performed.Outcomes:Gross findings revealed an ulcerated tumor with elevated margins and several perigastric and extragastric lymph nodes. Histological examination showed proliferation of atypical lymphocytes with a Ki67 index of 100%; they were marked by CD20, CD79a, bcl-6, and CD10 and were negative for CD3, CD5, CD23, TdT, bcl-2, and Cyclin D1. The tumor cells crossed the serosa and presented invasion of the lymph nodes. The patient died 10 days after surgery due to bronchopneumonia and acute renal failure.Lessons:In our department, only one gastric BL was diagnosed in a 61 consecutive lymphomas of the gastrointestinal tract (1.64%). Less than 200 reports about gastric-BL have been published to date. This case highlights the difficulty of diagnosis of rare variants of aggressive gastric lymphomas in medium-income countries without screening programmes.

show abstract

“…A number of reports have suggested that PHL could evolve in patients with chronic hepatitis, cirrhosis, systemic lupus erythematosus, and in transplant patients who were being treated with immunosuppressive drugs. [14][15][16][17][18][19][20][21][22][23][24][25] Thirteen patients had a history of preexisting liver disease in our series (31.7%); 6 patients had chronic hepatitis (14.6%), 4 patients cirrhosis (9.8%), and 1 patient polycystic liver disease (2.4%); 4 patients were diagnosed after liver transplantation (9.8%). Lymphoproliferative disorders after transplantation have been developed in transplant recipients.…”

Section: Discussionmentioning

confidence: 99%

Primary Hepatic Lymphoma: A Retrospective, Multicenter Rare Cancer Network Study

Uğurluer

Miller

et al. 2015

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

Primary hepatic lymphoma (PHL) is a rare malignancy. We aimed to assess the clinical profile, outcome and prognostic factors in PHL through the Rare Cancer Network (RCN). A retrospective analysis of 41 patients was performed. Median age was 62 years (range, 23-86 years) with a male-to-female ratio of 1.9:1.0. Abdominal pain or discomfort was the most common presenting symptom. Regarding B-symptoms, 19.5% of patients had fever, 17.1% weight loss, and 9.8% night sweats. The most common radiological presentation was multiple lesions. Liver function tests were elevated in 56.1% of patients. The most common histopathological diagnosis was diffuse large B-cell lymphoma (65.9%). Most of the patients received Chop-like (cyclophosphamide, doxorubicin, vincristine, and prednisone) regimens; 4 patients received radiotherapy (dose range, 30.6-40.0 Gy). Median survival was 163 months, and 5-and 10-year overall survival rates were 77 and 59%, respectively. The 5-and 10-year disease-free and lymphoma-specific survival rates were 69, 56, 87 and 70%, respectively. Multivariate analysis revealed that fever, weight loss, and normal hemoglobin level were the independent factors influencing the outcome. In this retrospective multicenter RCN study, patients with PHL had a relatively better prognosis than that reported elsewhere. Multicenter prospective studies are still warranted to establish treatment guidelines, outcome, and prognostic factors.

show abstract

Primary Hepatic Circumscribed Burkitt's Lymphoma that Developed after Acute Hepatitis B : Report of a Case with a Review of the Literature

Cited by 10 publications

References 18 publications

Primary hepatic lymphoma mimicking hepatocellular carcinoma: case report and review of literature

Primary hepatic lymphoma mimicking hepatocellular carcinoma: case report and review of literature

Gastric Burkitt lymphoma

Primary Hepatic Lymphoma: A Retrospective, Multicenter Rare Cancer Network Study

Contact Info

Product

Resources

About