Primary headache and multiple sclerosis: preliminary results of a prospective study

Villani, Veronica; Prosperini, Luca; Ciuffoli, Alessandro; Pizzolato, Raffaella; Salvetti, Marco; Pozzilli, Carlo; Sette, Giuliano

doi:10.1007/s10072-008-0908-3

Cited by 49 publications

(47 citation statements)

References 10 publications

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“…In another prospective study with no control group, Villani et al reported that the life-long prevalence of primary headaches in 102 patients with MS was 61.8% (12). In yet another prospective study without a control group undertaken by Boneschi et al, the life-long prevalence of headache was found to be 35.5% in 428 patients with MS (24).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, although some studies showed that RRMS could be correlated with migraines, this issue could not be confirmed with other studies (3)(4)(5)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). In another study, it was suggested that deregulation of the serotonergic system may also be involved in the pathogenesis of MS as well as migraines (13).…”

Section: Introductionmentioning

confidence: 88%

“…Despite the presence of publications reporting that the onset of headaches could be concomitant with the onset of MS symptoms and that headaches can show recurrence during the attack period in patients with relapsing remitting MS (RRMS), there are opposite suggestions in English-based literature (3)(4)(5)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). Moreover, although some studies showed that RRMS could be correlated with migraines, this issue could not be confirmed with other studies (3)(4)(5)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

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Headache in multiple sclerosis

Sorgun¹,

Yücesan²,

Genç³

2013

Turk J Med Sci

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The methanol extract of Plantago major subsp. intermedia (Gilib.) Lange afforded 4 known compounds, namely isomartynoside (1), 10-hydroxymajoroside (2), β -sitosterol (3), and ursolic acid (4). Their structures were established by spectroscopic methods. After determination of the total phenolic and flavonoid contents of the methanol extract, the antioxidant potentials of the crude extract and isolated compounds 1-4 were determined by β -carotene bleaching, DPPH free radical and ABTS cation radical scavenging, and cupric reducing antioxidant capacity methods. The methanol extract, rich in phenolic contents, indicated the same DPPH free radical scavenging activity (72% inhibition) as a standard compound, butylated hydroxytoluene, at 100 μ g/mL. Isomartynoside (1), a phenylpropanoid glycoside, showed the best inhibition of lipid peroxidation, ABTS cation radical scavenging activity, and cupric reducing antioxidant capacity among the tested samples. The anticholinesterase effects of the methanol extract and isolated compounds 1-4 were established using the Ellman method. A triterpenic acid, ursolic acid (4), exhibited moderate acetyl-(54.01 ± 0.82%) and butyryl-cholinesterase (68.74 ± 0.36%) inhibitory activity at 200 μ g/mL. Isomartynoside (1) was isolated here for the first time from a Plantago species; the antioxidant and anticholinesterase activities of P. major subsp. intermedia and compounds 1-2 were not previously determined.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Headache in multiple sclerosis

Sorgun¹,

Yücesan²,

Genç³

2013

Turk J Med Sci

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“…Relapsing remitting MS (RRMS)'de baş ağrısının, ilk MS semptomları ile be-raber başlayabildiğine, baş ağrısının ataklar döneminde rekürrens göstere-bildiğine dair çalışmalar mevcuttur (3-5, [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Bir başka makalede atak sıra-sında migreni olan 3 olgu sunumundan hareketle, MS'in patogenezinde de migrende olduğu gibi serotenerjik sistemin disregülasyonunun yer alabileceği ileri sürülmüştür (13).…”

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Multipl Sklerozda Baș Ağrısı ve Fonksiyonel Sistem Tutulumu

Sorgun¹,

Yücesan²

2011

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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Amaç: MS atakta baș ağrısı olabileceğine dair olgu bildirimleri vardır. Atakta baș ağrısı ile fonksiyonel sistem tutulumlarını değerlendiren bir çalıșma yoktur. Bu çalıșmanın amacı atakta baș ağrısı varlığı ve tipi ile fonksiyonel sistem tutulumu arasında ilișki olup olmadığının araștırılma-sıdır. Hastalar ve Yöntem:Çalıșmaya katılmayı kabul eden atak dönemindeki 64 MS değerlendirildi; anamnezinde depresyonu olan ve/veya Hamilton depresyon skalasından 8 ve üzerinde puan alan 16 hasta çalıșmaya alınmadı ve 48 MS hastası üzerinden değerlendirme yapıldı. Bu hastaların baș ağrıları sorgulandı ve nörolojik muayeneleri yapıldı. Bulgular: 48 hastanın 17'sinde (%35,4) remisyonda olan baș ağrısı atak döneminde de vardı. Sadece atak döneminde baș ağrısı olan hasta yoktu. Baș ağrısı olan hastaların 9'unda (%52,9) gerilim tipi baș ağrısı, 7'sinde (%41,2) migren, 1'inde sınıflandırılamayan baș ağrısı (%5,9) vardı. Atak dönemindeki fonksiyonel sistem tutulum bulguları ile atak döneminde baș ağrısının varlığı ve tipleri arasında ilișki saptanmadı.Yorum: MS hastalarının yaklașık 1/3'ünde ataklar baș ağrısını tetiklemektedir. Atak döneminde baș ağrısının varlığı ve tipi ile nörolojik muayenede etkilenen fonksiyonel sistemler arasında ilișki yoktur.Anahtar sözcükler: Multipl skleroz, migren, gerilim tipi baș ağrısı, fonsiyonel sistem tutulumu ABSTRACT Objective: There have been case reports suggesting relapses may cause headache in MS patients. It has not been investigated if there is any relation between attack-related headache and involvement of functional systems in MS patients. The aim of the study was to evaluate if there was any correlation between functional system involvement in neurological examination and the presence and/or type of headache. Patients and Methods:Sixty-four MS patients who were in relapse period were evaluated for the study; 16/64 patients who had depression in their past medical history and/or had >8 score in Hamilton depression scale were excluded; 48 MS patients were included the study. The patients were questioned about headache and were underwent a complete neurological examination.Results: Seventeen (%35,4) of 48 MS described headache in both remission and relapse period. None of the patients described headache in only relapse period. Nine patients had tension type headache (%52,9), 7 patients had migraine (%41,2), and 1 patient had unclassified headache (%5,9). It was not found any relation between any functional system involvement and the presence and/or types of headaches in MS attacks. Conclusion:Relapses triggers headache about 1/3 of MS patients. There is not relation between attack-related headache and functional system involvement in neurologic examination.

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“…Headaches are not integrated, although since 2000, almost every study about headache in MS showed a high prevalence of up to 78% [5][6][7][8]. A possible reason could be that headaches are considered a coincident disease and not a symptom of MS.…”

Section: Introductionmentioning

confidence: 99%

Headache at the Time of First Symptom Manifestation of Multiple Sclerosis: A Prospective, Longitudinal Study

et al. 2018

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Aims: Headaches have not been considered a typical symptom of multiple sclerosis (MS), although since 2000, almost every study showed high prevalence. We screened 50 MS patients at the time of first occurrence of neurological symptoms and found the highest prevalence of headache in MS that was ever recorded (78%). Postmortem histological analyses of MS patients’ brains revealed lymphoid follicle-like structures in the cerebral meninges and a pathophysiological link between headache, and high inflammatory activity especially in the initial phase of MS could be suspected. The aim of this study was to get insights into the persistence of headache in the further progress of the disease. Methods: In a prospective, multicenter study, 50 MS patients at the time of first symptom manifestation were screened for the presence of headache within the last 4 weeks and again 6 months later with help of the Rostock Headache Questionnaire (Rokoko) as well as using the evaluation of case history and clinical-neurological investigation. Results: We found a decrease of headache prevalence after 6 months from 78 to 61% (p = 0.01). We could also show a decrease of headache frequency, measured by days with headache in the last 4 weeks (9.5 vs. 5.9, p = 0.001). Migraine or probable migraine was the most frequent headache. In both investigations, the most frequent headache was recurrent pain with pulsating and throbbing character that lasted between 4 and 72 h. Conclusion: Headaches should be taken seriously as an important symptom in early MS. The decrease of headache 6 months after first symptom manifestation of MS could be a result of the immunomodulatory therapy. Young patients in whom migraine-like headaches occur should obligatory undergo an MRI of the head, and in the case of abnormal findings differential diagnosis should be initiated. This could reduce latency until final diagnosis of MS and enable early treatment.

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Primary headache and multiple sclerosis: preliminary results of a prospective study

Cited by 49 publications

References 10 publications

Headache in multiple sclerosis

Headache in multiple sclerosis

Multipl Sklerozda Baș Ağrısı ve Fonksiyonel Sistem Tutulumu

Headache at the Time of First Symptom Manifestation of Multiple Sclerosis: A Prospective, Longitudinal Study

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