Primary glioblastoma of the cerebellar vermis: A case report

Jing, Xiaolin; Shen, Guohua; Su, Minggang; Tian, Rong; Jia, Zhiyun

doi:10.3892/ol.2015.3188

Cited by 4 publications

(3 citation statements)

References 8 publications

(14 reference statements)

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“…[1] Positron emission tomography/computed tomography (PET/CT) with fluorine-18-fluoro-deoxyglucose (FDG) is sometimes advised and may offer additional alternatives for differential diagnoses when accessible. [5] As in the case of PET/CT, if it is available, the Thallium-201 (Tl) single photon emission computed tomography (SPECT) imaging can be also used in the diagnosis of brain tumors. Both techniques, SPECT and PET, characterize and measure biological processes.…”

Section: Resultsmentioning

confidence: 99%

“…Positron emission tomography/computed tomography (PET/CT) with fluorine-18-fluorodeoxyglucose (FDG) is sometimes advised and may provide additional alternatives for differential diagnoses when accessible. [5] Similar to PET/CT, Thallium-201 (Tl) single photon emission computed tomography (SPECT) imaging can be used to diagnose brain cancer if it is accessible. SPECT and PET both have the ability to identify biological processes at the cellular and molecular levels.…”

Section: Introductionmentioning

confidence: 99%

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Posterior Fossa Glioblastoma, Case Report, and Reviewed Literature

Januário¹

2022

Clin Cancer Investig J

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Glioblastomas multiformes (GBMs), are the most common primary malignant tumors of the Central Nervous System. Frequently located in supratentorial topography, infratentorial location is rare, around 0-3.4% of primary GBMs. The diagnosis of these tumors is uncommon in adults, few cases have been reported, being even more infrequent in elderly patients. The most typical clinical presentation is a rapidly growing posterior fossa lesion, increased intracranial pressure, and cerebellar signs associated with the mass and perilesional edema. Clinical presentation, computed tomography (CT), and magnetic resonance imaging (MRI) provide useful information about the possible diagnosis but are not definitive. We describe a clinical case, 76 years old female with a clinical history of hypertension, depressive syndrome, and dyslipidemia. Started progressively with ataxy, imbalance, and vertigo. Brain CT shows an intra-axial, infiltrative lesion in the superior and middle vermis. MRI presents a heterogeneous lesion in the superior and median vermian region of the cerebellum with ring enhancement and central necrotic area. Was performed a middle suboccipital approach, corticectomy in the superior vermis. The intraoperative histological study reveal a high-grade malignancy astrocytoma, which was released through a subtotal resection. The histological result was a high-grade astrocytoma, grade IV in WHO classification. Four weeks after the surgery the patient started treatment with chemotherapy and radiotherapy. The main point of this case is the atypical location of the tumor. These lesions are rare in this location but they will do considering the differential diagnosis of posterior fossa tumors. However, the most frequent lesions with high percentages of incidence are metastatic lesions.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Posterior Fossa Glioblastoma, Case Report, and Reviewed Literature

Januário¹

2022

Clin Cancer Investig J

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“…The origin of cerebellar cystic GBM is not completely understood. Given the proportion of neurons within the cerebellum in comparison to the number of neurons in the supratentorial compartment, around 10% of GBM's [1] should be located in this region, a number far superior to the 0.4–3.4% that has been cited [2]. Some of the literature has described cerebellar astrocytes having a lesser tendency for malignant transformation, even though this is an assumption based on the above epidemiology with no clear explanation behind it [3].…”

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confidence: 99%

Cerebellar cystic glioblastomas: An uncommon presentation of a rare disease and clinical review

et al. 2019

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Characteristics of cerebellar glioblastomas in adults

et al. 2017

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Adult cerebellar glioblastomas (cGBM) are rare and their characteristics remain to be fully described. We analyzed the characteristics of 17 adult patients with cGBM and compared them to a series of 103 patients presenting a supra-tentorial glioblastoma (stGBM). The mean age at GBMc diagnosis was 53.4 years (range 28-77). A history of neurofibromatosis type I was noted in 3 patients. cGBM were hemispheric in 10 patients (58.8%), only vermian in 4 patients (23.5%), and both vermian and hemispheric in 3 patients (17.7%). A H3 K27M mutation was identified in 3/14 patients, a TERT promoter mutation in 3/14 patients and a methylated MGMT promoter in 3/14 patients. None of the patients (0/14) harbored an EGFR amplification, an IDH or a BRAF mutation. Association with neurofibromatosis type I and H3K27M mutations were mutually exclusive. Compared with stGBM, cGBM occurred in younger patients (53.4 vs. 63.2, p = 0.02), were more frequently associated with neurofibromatosis type I (18 vs. 1%, p = 0.009) and with a H3 K27M mutation (21 vs. 3%, p = 0.02). They also tended to have a more frequent multifocal presentation at diagnosis (21 vs. 4.3%, p = 0.06), more frequently resulted in leptomeningeal or intra-axial metastasis (44.5 vs. 5%, p = 0.002) and were associated with a shorter median overall survival (5.9 vs. 14.2 months, p = 0.004). The present study suggests that adult cGBM differ from their supra-tentorial counterpart and constitute a heterogeneous group of IDH wild-type gliomas with at least two subgroups, one associated with H3K27M mutations and the other with neurofibromatosis type I.

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Primary glioblastoma of the cerebellar vermis: A case report

Cited by 4 publications

References 8 publications

Posterior Fossa Glioblastoma, Case Report, and Reviewed Literature

Posterior Fossa Glioblastoma, Case Report, and Reviewed Literature

Cerebellar cystic glioblastomas: An uncommon presentation of a rare disease and clinical review

Characteristics of cerebellar glioblastomas in adults

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