Primary glaucoma etiology: current theories and researches

Petrov, Sergey Yuryevich; Юрьевич, Петров Сергей; Fokina, Nnatal'ya Dmitrievna; Дмитриевна, Фокина Наталья; Sherstneva, L V; Валентиновна, Шерстнева Людмила; Vostruhin, Sergey Viktorovich; Викторович, Вострухин Сергей; Сафонова, Д. М.; Максимовна, Сафонова Дарья

doi:10.17816/ov2015247-56

Cited by 5 publications

(2 citation statements)

References 41 publications

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“…The content of TNFα in IOF reflects its formation in the retina by activated astrocytes under the action of inflammatory mediators, free radicals, end products of glycation (AGE), products of ischemic injury [7,12,13]. In POAG, a correspondence was found between the increase in the content of TNFα in the retina and the rate of death of ganglion cells [14]. Through its specific receptors, this 90 80 70 60 50 40 30 20 10 0 100 90 80 70 60 50 40 30 20 10 0 100 90 80 70 60 50 40 30 20 cytokine induces the formation of the proapoptotic complex DISC (death-inducing signalling complex) and activates the subsequent kinase cascade (MARK/ERK kinase-1/JNK/caspase-8) [18].…”

Section: Discussionmentioning

confidence: 99%

“…Important inducers of GON include tumour necrosis factor-α (TNFα), which induces apoptosis of retinal ganglion cells; marked correlation between its level in the retina and the rate of ganglion death cells [13,14]. Under the influence of TNFα, matrix activation occurs metallopro-teinases, which lead to degradation of intercellular components substances that modulate the tissue of the optic disc, disrupt hemato-ophthalmic barrier [15].…”

Section: Introductionmentioning

confidence: 99%

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Prognosis of Postoperative Progression of Glaucoma Optic Neuropathy at Primary Open-Angle Glaucoma

Serdiuk¹

2020

EUREKA: Health Sciences

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Search for new informative markers and methods of prognosis prediction glaucomatous optic neuropathy (GON) in primary open-angle glaucoma (POAG) is an urgent task. We have established efficiency surgical treatment of POAG, but the progression of GON is observed in 10–15 % patients. It is known that the main mechanism of GON is apoptotic death retinal ganglion cells, a marker of which is recognized as tumour necrosis factor-α (TNFα), Fas-ligand (FasL) and a soluble form of the Fas-receptor (sFas/APO-1). The aim of the study: to find out the possibility of using apoptosis factors (TNFα, FasL and sFas/APO-1) to predict postoperative progression of GON at POAG. Methods. 69 patients (69 eyes) with POAG stage I–III were examined, who underwent trabeculectomy with implantation of an Ex-Press shunt. In intraocular fluid (IOF) markers of apoptosis was determined by the method enzyme-linked immunosorbent assay. Repeated ophthalmological examination was performed in 1 year. The control group consisted of 25 patients who were operated on about phacoemulsification of cataracts. For statistical and regression analysis used software package GLZ (Statistica 10, StatSoft, Inc. USA) and module of analysis of operational characteristics of regression models – ROC-diagrams (MedCalc 18.9.1, MedCalc Software, Belgium). Results. Multivariate regression analysis showed that the progression of GON determine the content in IOF of TNFα and sFas/Apo-1 before surgery and intraocular pressure after three months. Based on these indicators, it is calculated satisfactory model of GON progression prediction with 95.4 % accuracy. One-factor logistic regression analysis proved the influence of the content of TNFα, FasL and sFas/Apo-1 for the presence or absence of progression of GON during the year after operations: direct dependence took place for TNFα and FasL and inverse – for sFas/Apo-1. The critical limits of the content in the IOF markers are calculated apoptosis, in which the progression of GON is unmistakably predicted during year after surgery. Conclusions. The obtained results prove the significant influence of the studied markers apoptosis on the progression of GON after surgery. Direct pathogenetic influence belongs to TNFα and FasL.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prognosis of Postoperative Progression of Glaucoma Optic Neuropathy at Primary Open-Angle Glaucoma

Serdiuk¹

2020

EUREKA: Health Sciences

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Accumulation of sulfur and phosphorus in the eye’s drainage system in primary open-angle glaucoma

Kravchik¹,

Ia²,

Subbot³

et al. 2020

Vestn. oftal'mol.

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РЕЗЮМЕ Цель исследования. Изучить химический состав склеры и трабекулярной ткани глаза при первичной открытоугольной глауко ме (ПОУГ). Оценить взаимосвязь роговично-компенсированного внутриглазного давления (ВГД) и химического состава дренажной зоны. Материал и методы. Было определено содержание ряда химических элементов: углерода (С), азота (N), кислорода (O), алюминия (Al), кальция (Са), хлора (Cl), калия (К), магния (Mg), натрия (Na), фосфора (P), кремния (Si), серы (S) в 89 биоптатах трабекулярной ткани и в 41 биоптате склеры у пациентов с ПОУГ, использующих максимальную местную гипотензивную терапию. Выбор анализируемых элементов был обусловлен химическим строением анализируемой ткани и чувствительностью инструмента, используемого для анализа. Визуализацию проводили с помощью сканирующего электронного микроскопа EVO LS 10 (Zeiss, Германия), исследование химического состава-с использованием энергодисперсионного спектрометра Oxford-X-MAX-50 (Oxford, Великобритания). В качестве статистических критериев оценки использовали тест Спирмена. Результаты. Обнаружены прямые корреляции между уровнем ВГД у пациентов с ПОУГ и общим содержанием S, P, Ca в трабекуле. Показана аккумуляция ассоциированных с пигментными гранулами серосодержащих соединений в трабекулярной ткани при ПОУГ. Прослежена связь между органической и неорганической (минеральной) формами нахождения P в трабекуле при ПОУГ в зависимости от уровня офтальмотонуса. Для P установлено преобладание органического компонента над минеральным при увеличении уровня ВГД у пациентов с открытоугольной глаукомой. Заключение. У пациентов с ПОУГ при повышении уровня ВГД в ткани трабекулы увеличивается количество S, ассоциированной с пигментными гранулами, и возрастает доля органического P, что следует учитывать при дальнейшем поиске медикаментозной терапии, потенциально воздействующей на патологически измененную ткань.

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A review on glaucoma: causes, symptoms, pathogenesis & treatment

Mahendra Kumar

2024

J Clin Res Ophthalmol

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If glaucoma is not treated, it can worsen and cause irreparable vision loss. It results from elevated intraocular pressure that gradually deteriorates the optic nerve. It is unclear exactly what causes this build-up of pressure, but several factors, including age, genetics, and specific medical disorders, may be involved. Glaucoma frequently has mild symptoms that take time to manifest and may not be apparent until considerable harm has already been done. Early detection and treatment can help prevent additional vision loss, which is why routine eye exams are so crucial. In order to reduce intraocular pressure, glaucoma is usually treated with medication or surgery. Eye drops, tablets, or a mix of the two can be prescribed. Traditional filtration surgery is one of the surgical options or more recently less invasive techniques. Glaucoma is a dangerous eye condition that needs to be closely watched over and managed. Although early diagnosis and therapy can help protect vision and prevent additional impairment, there is currently no treatment for the disease. People who are at elevated risk for glaucoma, including those who have a family history of the condition or who are older than 60, should make an appointment for regular checkups with an ophthalmologist to be checked for glaucoma symptoms. The article's summary will aid researchers in their efforts to improve glaucoma treatment.

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Primary glaucoma etiology: current theories and researches

Cited by 5 publications

References 41 publications

Prognosis of Postoperative Progression of Glaucoma Optic Neuropathy at Primary Open-Angle Glaucoma

Prognosis of Postoperative Progression of Glaucoma Optic Neuropathy at Primary Open-Angle Glaucoma

Accumulation of sulfur and phosphorus in the eye’s drainage system in primary open-angle glaucoma

A review on glaucoma: causes, symptoms, pathogenesis & treatment

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