Primary gingival squamous cell carcinoma in a xeroderma pigmentosum type C patient

Trichothiodystrophy, complementation group A complicated with squamous cell carcinoma

“…Most disseminated, visceral and fungaemia forms of sporotrichosis are associated with immunosuppression, and studies report less than 5%; nonetheless, our study was 13.8%. 1,2,7 In this report, the cutaneous manifestations we found were mainly nodules, papules, necrotic lesions, ulcers and verrucous plaques, located in different segments of the body (Fig. 1).…”

“…1,7,8 The mucosal involvement of sporotrichosis is rare and was observed in 16% with ulcerations in oral mucosa. 1,2,7,8 In our study, the two most frequent predisposing factors were uncontrolled diabetes and chronic alcoholism. These has been previously reported, and it can explain the immunological deterioration, related with cellular response especially to macrophage dysfunction.…”

“…1). 1,2,7,8 The three cases with visceral dissemination were associated with severe immunosuppression. Finally, a patient who presented the most severe and lethal form was associated with aplastic bone marrow failure due organophosphorus (pesticides).…”

“…1 Photosensitivity, neurological/developmental abnormalities and skin cancer are important pathological features that can be used to distinguish between these three archetypes. 1,2 TTD is a rare, autosomal recessive disease characterized by brittle, sulphur-deficient hair and multisystem abnormalities. 3 The general TFIIH subunit 5 (GTF2H5) gene, GTF2H5, is known to be a causative gene of TTD, complementation group A (TTDA, OMIM#616395).…”

“…It is a polymorphic disease, and cutaneous lymphatic is the most frequent (75-90%). [1][2][3] We report our 25 years' experience in cutaneous disseminated sporotrichosis (CDS). We conducted an open, retrospective and observational study.…”