Primary giant lymphoma of the right thigh: A case report and brief review of the literature

Abstract

Abstract. Primary soft tissue non-Hodgkin lymphoma (NHL) of the extremities is very rare. The clinical features of NHL mimic those of other soft tissue tumors, particularly sarcoma; however, they should be differentiated, as the treatment and prognosis are completely different. In this study, the case of a 68-year-old female with a giant mass, movement disorder, numbness and painful sensations in the right thigh is presented. Magnetic resonance (MR) imaging revealed a huge circle-shaped mass. Fine needle aspiration cytology (FNAC) of the tumor demonstrated neoplastic small, round cells. The tentative diagnosis was of a mesenchymal sarcoma. The right thigh was amputated. On histological examination of the amputated extremity, the diagnosis was found to be large B cell lymphoma. Primary soft tissue NHL of the extremities is a systemic malignant disease and is sensitive to chemotherapy and radiotherapy. The histological diagnosis should be identified as far as possible before the tumor is widely excised.

Diagnosis of B‐cell lymphoma from gluteal muscle mass

“…Extranodal involvement of NHL is approximately 20%‐30% . Primary extranodal, located only on the extranodal site, commonly arise from gastrointestinal tract whereas, primary skeletal muscle non‐Hodgkin's lymphoma (PSM NHL) is rare, and constitutes up to 0.1 to 0.5% of NHL . Skeletal muscle is involved by lymphoma either in the course of disseminated disease, spread from contiguous lymph node or as a primary extranodal lesion.…”

Solitary large malignant lymphoma in the head and neck region

“…FNAC is a highly accurate, safe and cost-effective method, which is widely used in initial tests for the histopathological evaluation of neck masses (1). However, it is not recommended for the diagnosis of malignant lymphoma because the tumor tissue architecture cannot be obtained (1,6). Based on the FNAC results of the present study, malignancy was found in only one case and atypical lymphoid lesions were suspected in three cases.…”

“…Accurate diagnosis and treatment of solitary large malignant lymphoma requires multidisciplinary collaboration (5,6). The histopathologic examination through surgical excision and subtype confirmation through immunophenotyping are essential (1)(2)(3)(4)(5)(6)(7). Treatment for malignant lymphoma of the head and neck may include systemic chemotherapy with or without radiation therapy.…”

“…Non-Hodgkin lymphoma accounts for ~90% of all lymphoma (5). Treatment of malignant lymphoma is very diverse and treatment is only possible with an accurate diagnosis (5,6). Treatment of malignant lymphoma is very diverse and treatment is only possible with an accurate diagnosis (6).…”

“…Treatment of malignant lymphoma is very diverse and treatment is only possible with an accurate diagnosis (5,6). Treatment of malignant lymphoma is very diverse and treatment is only possible with an accurate diagnosis (6). The prognosis of patients with early-stage disease was improved compared with that of patients with late-stage disease (5).…”