Primary giant cell tumor of soft tissue: fluid-fluid levels at MRI (2010:3b)

Morís, A.R. Meana; González, P. García; Martín, Eduardo; Suarez, Carmen Gonzalez; Barrero, Luis Moro

doi:10.1007/s00330-009-1528-x

Cited by 17 publications

(4 citation statements)

References 15 publications

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“…Hu et al reported the tumor exhibited predominantly slight hyperintensity on T2 images and intensely heterogeneous enhancement on contrast-enhanced T1-weighted images [ 6 ]. Moris reported a case with a hypointense rim on T2-weighted images [ 9 ]. In our MRI, the viable solid lesion was shown as the lower intensity of T2-weighted images, and the necrotic lesion was shown as irregular shape of isointensity on T2-weighted images.…”

Section: Discussionmentioning

confidence: 99%

First Case Report of a Huge Giant Cell Tumor of Soft Tissue Originating from the Retroperitoneum

Kishi¹,

Monma²,

Hori³

et al. 2018

Am J Case Rep

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Patient: Male, 78Final Diagnosis: Giant cell tumor of soft tissueSymptoms: Fatigue • weight lossMedication: —Clinical Procedure: Surgical resectionSpecialty: SurgeryObjective:Rare diseaseBackground:Giant cell tumor of soft tissue (GCT-ST) is a rare disease generally generated from superficial tissue. We report an extremely rare case of giant cell tumor of soft tissue arising from retroperitoneal tissue.Case Report:A 78-year-old man visited our medical center with the chief complaint of fatigue and weight loss for 1 month. He had a hard and immobilized mass without pain in the left upper quadrant. Contrast-enhanced CT showed a huge tumor (22×20×16 cm) in the retroperitoneal space, and it invaded into the stomach, colon, pancreas, spleen, and left kidney. MRI demonstrated the tumor had a serous cystic component as T1 was low, T2 was high, and DWI was slightly high. We diagnosed the retroperitoneal malignant tumor, and tumor resection was performed with total gastrectomy, partial colectomy, distal pancreatectomy, left nephrectomy, and left adrenal-ectomy for complete resection, without any postoperative complications. The tumor predominantly consisted of a solid mass, and had necrotic lesions, cystic lesions, and calcification. The histological exam showed it was composed of spindle and multinucleated giant cells; however, there was no cellular atypia or pleomorphism. Immunohistochemical staining characterized the tumor with CD68+, SMA+, CD34–, Desmin–, and S-100–. We finally diagnosed it as GCT-ST with the intermediate group of malignancy, according to WHO criteria. Thereafter, the patient had no recurrence at 1 year after resection.Conclusions:The huge GCT-ST arising from the retroperitoneal space, which has never before been reported, was successfully resected. We report it with pathological findings to add to the relevant literature.

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Section: Discussionmentioning

confidence: 99%

First Case Report of a Huge Giant Cell Tumor of Soft Tissue Originating from the Retroperitoneum

Kishi¹,

Monma²,

Hori³

et al. 2018

Am J Case Rep

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“…Clinically, primary GCT-ST mainly affects young to middle-aged adults[ 4 - 11 , 16 ]. Here, our patient was a young woman who had an ill-circumscribed multinodular mass covered by a fleshy red-brown surface and pain in the upper limb.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of primary giant cell tumor in soft tissue on magnetic resonance imaging: A case report

Kang¹,

Zhang²,

Liu³

et al. 2021

WJCC

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BACKGROUND Primary soft tissue giant cell tumor (GCT-ST) is rare and has relatively low malignant potential. Most reports are pathological and clinical studies, while imaging studies have only been reported in cases of adjacent bone or with atypical cystic degeneration. With regard to the findings on magnetic resonance imaging (MRI) or ultrasonography, superficial masses can be further identified based on facial edema, skin thickening, skin contact, internal hemorrhage or necrosis and lobulation of the mass. Unlike deep-seated masses, MRI features do not always provide an accurate diagnosis for benign and malignant patients with superficial soft-tissue lesions. Thus, the application of diffusion-weighted imaging (DWI) to evaluate superficial soft tissue tumors is necessary. CASE SUMMARY A 36-year-old woman who had a suspected malignant tumor in the upper limb on ultrasound and computed tomography is reported. The signal intensity of the suspected tumor was heterogeneous on plain MRI; nodular and heterogeneous enhancement was observed in the tumor with irregular shapes and blurred margins on dynamic contrast-enhanced MRI. The lesion on DWI was hyperintense with a higher mean apparent diffusion coefficient (ADC) value. Finally, a GCT-ST was confirmed by pathology. This case suggests that GCT-ST should be distinguished as a benign soft tissue mass from giant cell-rich soft tissue neoplasms or malignant tumors. CONCLUSION The MRI features of the superficial GCT-ST in the upper limb included heterogeneous signal intensity within the lesion on T2-weighted image (T2WI) and T1-weighted fat-saturation spoiled gradient recalled echo (T1 FSPGR), nodular enhancement with blurred margins, irregular shapes, and a slow-increased enhancement. DWI could be used to differentiate a benign soft tissue mass from a malignant mass by the mean ADC value and provide more radiologic-pathologic information for the diagnosis of GCT-ST. Comprehensive imaging of primary GCT-ST could help complete tumor resection, and in turn likely prolong survival after surgery.

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“…On histopathology, soft tissue ABCs usually contain more reactive osteoid and woven bones, but fewer giant cells than a giant cell tumor of soft tissue or giant cell tumor of the tendon sheath. [ 18 ]…”

Section: Discussionmentioning

confidence: 99%

A rare cause of insidious shoulder pain in a young female: A soft tissue aneurysmal bone cyst in supraspinatus muscle

Özbayrak¹,

Külcü²

2021

Turk J Phys Med Rehab

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Primary giant cell tumor of soft tissue: fluid-fluid levels at MRI (2010:3b)

Abstract: GCT-ST should be included in the differential diagnosis of soft tissue tumors with FFLs.

Cited by 17 publications

References 15 publications

First Case Report of a Huge Giant Cell Tumor of Soft Tissue Originating from the Retroperitoneum

First Case Report of a Huge Giant Cell Tumor of Soft Tissue Originating from the Retroperitoneum

Characteristics of primary giant cell tumor in soft tissue on magnetic resonance imaging: A case report

A rare cause of insidious shoulder pain in a young female: A soft tissue aneurysmal bone cyst in supraspinatus muscle

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