Primary Generalized Infection Caused by Herpes Simplex Virus

Baker, W. H. J.; Lawton, Ann M.; McCarthy, K.

doi:10.1136/bmj.2.4798.1334

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…injection of HSV is unknown. However, since HSV viremias occur in neonates and immunosuppressed patients (3,8,19), the induction of hyporesponsiveness by this method may occur in vivo, contributing significantly to the dissemination of the infection. Whether circulating infected lymphocytes are present in either acutely or latently infected individuals has not been dettrmined, although this is not an unlikely possibility.…”

Section: Discussionmentioning

confidence: 99%

Tolerance and suppression of immunity to herpes simplex virus: different presentations of antigens induce different types of suppressor cells

Schrier¹,

Pizer²,

Moorhead³

1983

Infect Immun

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In this report, we examine tolerance (hyporesponsiveness) and suppression of delayed hypersensitivity (DH) to herpes simplex virus (HSV) in mice, using two different forms of tolerogen: HSV particles and HSV-infected spleen cells. The intravenous injection of mice with either HSV particles or spleen cells 7 days before subcutaneous immunization with virus induced a profound state of unresponsiveness. This unresponsive state was mediated, at least in part, by suppressor T cells (Ts), which were demonstrated by passive transfer to naive recipients. However, different types of T, were induced depending on the form of the tolerogen. The injection of HSV particles induced T, which suppressed the induction but not the expression of DH. On the other hand, the injection of HSV spleen cells induced two types of Ts: one which inhibited the induction of the DH response and one which inhibited the expression of DH to HSV. Both tolerance

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Section: Discussionmentioning

confidence: 99%

Tolerance and suppression of immunity to herpes simplex virus: different presentations of antigens induce different types of suppressor cells

Schrier¹,

Pizer²,

Moorhead³

1983

Infect Immun

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“…See footnote b to c To induce T,-aff, donor mice were injected i.v. with either 107 PFU HSV particles or 5 x 107 HSV SC (MOI,2). T,-eff were induced by i.v.…”

Section: Sc Treated With Either Infectious or Heat-inactivated Virusmentioning

confidence: 99%

Different forms of membrane-associated herpes simplex virus glycoproteins induce functionally distinct subsets of herpes simplex virus-specific suppressor T cells

Ishioka¹,

Pizer²,

Moorhead³

1985

J Virol

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Previous studies have shown that two types of virus-specific suppressor T cells (Ti) are induced in mice made tolerant with herpes simplex virus (HSV)-infected spleen cells (SC). One type of T. blocks the afferent phase of the delayed hypersensitivity response to HSV (T.-aff), and the other blocks the efferent or effector phase (Ts-eff). In this report we show that the induction requirements for these suppressor populations differ. Injection of SC infected for 6 h with HSV at a multiplicity of infection of 5 or less or treated with heat-inactivated virus induced only Ts-aff. Similar results were seen with SC incubated for 90 min in virus-free preparations containing only viral proteins. In contrast, the Ts-eff population was induced only by SC treated for 6 h with infectious HSV at a multiplicity of infection of 10. Collectively, these data indicate that Ts-aff are induced by adsorbed HSV antigens on SC, whereas Ts-eff are induced by nascent HSV antigens expressed on infected SC. In addition to their induction requirements, the two types of regulatory cells differ in their expression of effector function. Ts-eff but not Ts-aff require a cyclophosphamide-sensitive target cell in the immune recipient for suppressor function. The possible identity of this target cell and the significance of the different induction requirements between the two types of Ts are discussed.

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Die Herpesgruppe (Herpetische Erkrankungen des Menschen)

Nasemann¹,

Marchionini²

1961

Die Viruskrankheiten Der Haut

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Primary Generalized Infection Caused by Herpes Simplex Virus

Cited by 4 publications

References 8 publications

Tolerance and suppression of immunity to herpes simplex virus: different presentations of antigens induce different types of suppressor cells

Tolerance and suppression of immunity to herpes simplex virus: different presentations of antigens induce different types of suppressor cells

Different forms of membrane-associated herpes simplex virus glycoproteins induce functionally distinct subsets of herpes simplex virus-specific suppressor T cells

Die Herpesgruppe (Herpetische Erkrankungen des Menschen)

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