Primary gastrointestinal non-Hodgkin’s lymphoma: clinicopathological and prognostic analysis

Abstract

The objective is to investigate the association between pathological type and clinical features, response to treatment and prognosis of primary gastrointestinal Non-Hodgkin's lymphoma (PGINHL). The clinicopathologic features, response to treatment and survival of 124 patients with PGINHL, were investigated retrospectively. Ninety-one patients were treated with surgery, most of which included combined therapy, while 32 patients received chemotherapy alone. Survival analysis was performed by Kaplan-Meier and Cox regression method. The most common immunophenotype was B-cell subtype. In 115 (92.7%) patients of B-cell lymphoma, mucosa-associated lymphoid tissue lymphoma (MALToma) and diffuse large B-cell lymphoma (DLBCL) were 55 and 50 patients, respectively. The patients of two pathological types had different clinical features including stage, B symptoms, sites of tumor, distant involvement, International Prognosis Index Score, size of tumor, and response to treatment. Both overall survival curve and multiple Cox regression analysis indicated that pathological type was statistically significant. The pathological subtype of PGINHL was an important prognostic factor. The patients with MALToma appear to have more favorable prognosis than those with DLBCL.

The Lymphocyte–Monocyte Ratio and the Platelet–Lymphocyte Ratio at Diagnosis as Independent Prognostic Factors in Primary Gastrointestinal Diffuse Large B Cell Lymphoma

“…Primary gastrointestinal diffuse large B-cell lymphoma is the most common extranodal site involved by diffuse large B-cell lymphoma [12]. The international prognostic index Table 2 Patient characteristics according to the ALC C 1.5 9 10 9 /L versus \1.5 9 10 9 /L Characteristics Classification ALC C 1.5 9 10 9 /L ALC \ 1.5 9 10 9 /L p value (IPI) developed for DLBCL is, at present, the most valuable and widely used for the stratification of almost all subtypes of NHL.…”

Overexpression of DNA methyltransferase 1 as a negative independent prognostic factor in primary gastrointestinal diffuse large B-cell lymphoma treated with CHOP-like regimen and rituximab

“…Primary gastrointestinal (PGI) lymphoma is an extremely rare disease that accounts for 1-4% of all gastrointestinal malignancies (1). In general, gastrointestinal lymphoma is secondary to widespread nodal diseases.…”

Systemic lupus erythematosus presenting with eosinophilic enteritis: a case report

“…Primary intestinal lymphomas may present with abdominal pain, symptoms due to intestinal obstruction, bleeding and diarrhea. Histologic examination of tissue obtained from the involved area often results in a proper diagnosis [12]. …”