Primary gastrointestinal lymphoma: 30‐year experience at the cancer institute, madras, india

Chandran, Rekha; Raj, Elluswami Hemanth; Chaturvedi, Harit

doi:10.1002/jso.2930600109

Cited by 15 publications

(1 citation statement)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The PIL was seen predominantly in males (M:F of 5.8:1) as observed in other studies. 6 , 15 , 16 The age of onset of PIL varied from 45–70 years in the published studies. However, median age at diagnosis in our study was 44 years, which was one decade earlier as compared to the presentation of primary gastric lymphoma as reported by us in the previous studies and in concordance with other studies.…”

Section: Discussionmentioning

confidence: 99%

Primary Intestinal Lymphoma: Clinicopathological Characteristics of 55 Patients

Malipatel¹,

Patil²,

Rout³

et al. 2021

Euroasian Journal of Hepato-Gastroenterology

View full text Add to dashboard Cite

A bstract Introduction Gastrointestinal (GI) tract is the most common site of extranodal lymphoma accounting for 30–40% of the cases. In Western countries, stomach is the most common site of GI lymphoma, whereas in the Middle East and Mediterranean countries, small intestine is commonly involved. Studies about primary intestinal lymphoma (PIL) are heterogeneous in anatomical distribution, presentation, and histological subtypes. The present study was aimed at studying the anatomical distribution, histological subtypes, and clinical characteristics at tertiary care centers. Materials and methods The present study was retrospective, conducted between 2006 and 2020. Patient's data were collected from institutional medical records. PIL was diagnosed by Lewin's criteria. After histological diagnosis, PIL was classified as per the World Health Organization (WHO) criteria and staging was done according to the Ann Arbor classification as modified by Musshoff. Results A total of 941 lymphoma cases were diagnosed during the study period between 2006 and 2020 consisting of 238 Hodgkin's lymphoma and 703 non-Hodgkin's lymphoma (NHL) cases. PIL constituted 5.8% of all lymphoma cases (55 out of 941) and 50.9% (55 of 108) of all primary GI lymphoma. Median age at diagnosis was 44 years and comprised predominantly males (85.45%). Diffuse large B-cell lymphoma (DLBCL) and mucosa-associated lymphoid tissue (MALT) lymphoma were the most common histological subtype (78%) seen. Two patients with primary Hodgkin's lymphoma involving the intestine were seen. T-cell lymphoma was seen in three (5.4%) patients. Ileocecal region was the most common site involved (27%). The common presenting complaints were intestinal obstruction (40%) requiring surgical resection and abdominal pain (32%). Majority of the patients presented in the early stages (I and II). Conclusion Our study demonstrates the pattern of distribution and various histological subtypes of PIL including the rare variants like primary intestinal Hodgkin's lymphoma. Relatively more number of patients presented with intestinal obstruction requiring surgery in comparison with other studies. How to cite this article Malipatel R, Patil M, Rout P, et al . Primary Intestinal Lymphoma: Clinicopathological Characteristics of 55 Patients. Euroasian J Hepato-Gastroenterol 2021;11(2):71–75.

show abstract

Section: Discussionmentioning

confidence: 99%

Primary Intestinal Lymphoma: Clinicopathological Characteristics of 55 Patients

Malipatel¹,

Patil²,

Rout³

et al. 2021

Euroasian Journal of Hepato-Gastroenterology

View full text Add to dashboard Cite

show abstract

Primary gastrointestinal lymphoma in an Egyptian district: A study using a population-based cancer registry

Saber

Zeeneldin

Samra

et al. 2013

Journal of the Egyptian National Cancer Institute

View full text Add to dashboard Cite

show abstract

The modified International Prognostic Index can predict the outcome of localized primary intestinal lymphoma of both extranodal marginal zone B‐cell and diffuse large B‐cell histologies

et al. 2002

View full text Add to dashboard Cite

Summary. We have previously reported on the efficacy of a modified International Prognostic Index (MIPI) in predicting the outcome of patients with primary gastric lymphoma. This prompted the retrospective analysis of a large series of patients with primary intestinal lymphoma (PIL) of both diffuse large B-cell (DLCL) and low-grade (extranodal marginal zone B-cell lymphoma, MZL) histology. Clinical records of 122 patients with localized primary intestinal lymphoma of MZL (n ¼ 35) and DLCL (n ¼ 87) histology, confirmed by an ad hoc expert panel of pathologists, were reviewed. Forty-nine patients were treated with single therapy, while 72 received combined-modality treatment, which included surgery followed by a short-term chemotherapy. MIPI was included in a multivariate prognostic analysis for overall survival (OS) and event-free survival (EFS). Sixty-five patients (75%) with DLCL and 22 with MZL (65%) achieved complete remission. After a median follow-up of 42 months (range 6-163 months), 5-year estimates of OS and EFS were 68% and 50% for DLCL and 65% and 26% for MZL. OS varied according to MIPI, from, respectively, 86% and 87% for DLCL and MZL patients with 0-1 risk factor to 50% and 32% for patients with > 1 risk factor (P ¼ 0AE01 and P ¼ 0AE02). Similar results were obtained for EFS. Cox regression analysis showed an unfavourable MIPI to be the only independent predictor of shorter EFS. This retrospective study shows that stage-MIPI can be a reliable prognostic indicator for PIL of both lowgrade MZL and diffuse large B-cell histology, enabling the early identification of patients at higher risk of failure.

show abstract

Primary gastrointestinal lymphoma: 30‐year experience at the cancer institute, madras, india

Cited by 15 publications

References 88 publications

Primary Intestinal Lymphoma: Clinicopathological Characteristics of 55 Patients

Primary Intestinal Lymphoma: Clinicopathological Characteristics of 55 Patients

Primary gastrointestinal lymphoma in an Egyptian district: A study using a population-based cancer registry

The modified International Prognostic Index can predict the outcome of localized primary intestinal lymphoma of both extranodal marginal zone B‐cell and diffuse large B‐cell histologies

Contact Info

Product

Resources

About