Primary gastric squamous cell carcinoma with a bilio‐gastric fistula and Krukenberg syndrome

Abstract

Primary squamous cell carcinoma of the stomach is a rare type of gastric malignancies. Diagnosis criteria are well defined but diagnosis is generally late being made at an advanced stage with metastases explaining its poor diagnosis.

Gastric squamous cell carcinoma: A rare malignancy, literature review and management recommendations (Review)

“…The present literature review has several limitations: First, a reporting bias could exist due to the rarity of the pathology of which only a handful of cases have been reported. Second, a selection bias may exist, in that not all cases used the diagnostic criteria set by Parks (35), Boswell and Helwig (12), or the Japanese Gastric Cancer Association (34). It is likely that database analyses, such as the SEER database analysed by Dong et al (9) or the National Cancer Database analysed by Akce et al (6), are unable to assess the correctness of the diagnosis based on the three criteria listed by Parks (35) and will have most likely misclassified some cases.…”

“…GSCC is referenced by the World Health Organization classification under the number: ICD 8070/3 (7). The Japanese Gastric Cancer Association has set specific histological criteria for GSCC including: i) Tumour cells are exclusively SCC cells, with no adenocarcinomatous cell contingent, and ii) evidence that the GSCC arose from the gastric mucosa directly (34). Boswell and Helwig (12) were the first to set histological morphological criteria for GSCC.…”

“…Very little is known about the treatment for metastatic GSCC. To the best of our knowledge, only nine cases have been published (Table II), with clinicians using platinum-fluoropyrimidine or platinum-taxane doublet (18,23,34,(43)(44)(45)(46)(47)(48). Chemoradiotherapy was used in one case with capecitabine and oxaliplatin and reported survival of 27 months (18).…”