Primary gastric lymphomas: a clinicopathologic study with literature review

Roukos, Dimitrios H; Hottenrott, C; Encke, A.; Baltogiannis, Georgios; Casioumis, D.

doi:10.1016/0960-7404(94)90007-8

Cited by 72 publications

(34 citation statements)

References 53 publications

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“…Both survival and quality of life (QOL) of patients with adenocarcinoma of the stomach can be improved with appropriate treatment [3]. Although disease-free and overall survival have been improved due to standardized D2 gastrectomy [4][5][6][7][8][9][10][11] plus preoperative (neoadjuvant) or postoperative chemotherapy alone or plus radiotherapy [12][13][14], this improvement for patients with advanced potentially curable stage II and III disease is modest. Adjuvant molecularly targeting therapy for gastric cancer is still considered experimental and despite current limitations, there is hope that the next generation targeted agents will further prolong survival and cure rates for patients with solid cancers, including gastric cancer [15].…”

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Is laparoscopic gastrectomy safe for western patients with gastric cancer with high body mass index?

Kanellos

2009

Surg Endosc

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During the last decade, clinical outcomes of patients with gastric cancer have improved [1,2]. Both survival and quality of life (QOL) of patients with adenocarcinoma of the stomach can be improved with appropriate treatment [3]. Although disease-free and overall survival have been improved due to standardized D2 gastrectomy [4][5][6][7][8][9][10][11] plus preoperative (neoadjuvant) or postoperative chemotherapy alone or plus radiotherapy [12][13][14], this improvement for patients with advanced potentially curable stage II and III disease is modest. Adjuvant molecularly targeting therapy for gastric cancer is still considered experimental and despite current limitations, there is hope that the next generation targeted agents will further prolong survival and cure rates for patients with solid cancers, including gastric cancer [15].In contrast to the small cure rate and slow trend toward improvement, particularly in western countries, QOL has more rapidly and substantially been improved due to minimally invasive techniques, including endoscopic mucosal resection for small, early gastric cancers and laparoscopic surgery for more advanced tumors.The clinical success of laparoscopic gastrectomy in east Asian countries, predominantly Korea and Japan, has started to influence the treatment of gastric cancer. The trend from open to totally laparoscopic gastrectomy in the United States is here [16].High-volume surgeons and high-volume hospitals in laparoscopic surgery are considered surrogate predictors of safe performance with good QOL outcomes. In an absence of experience with laparoscopic technique and the relatively high body mass index (BMI) of western patients, how safe and efficient is laparoscopic gastrectomy in the west? Given the absence of large-scale data from western studies, information from laparoscopic gastrectomy in Asian patients could be clinically very useful for western surgeons planning future performance of laparoscopic gastrectomy for gastric cancer. Such studies can provide useful information about how to avoid postoperative complications after laparoscopic gastrectomy.Indeed, the large-scale study by Lee and colleagues [17], published recently in Surgical Endoscopy, gives answers to these critical for clinical practice questions. Based, on the clinical data of 1,485 patients with gastric cancer treated by laparoscopy-assisted gastrectomy (LAG) in ten institutions in Korea, the authors evaluated the impact of BMI on postoperative complications. Lee et al. [17] reported that overall there was no statistically significant difference for postoperative morbidity and mortality between the high BMI (15.7 and 0.9%) and low BMI (14 and 0.5%) groups (p = 0.37 and p = 0.29). However, the operation time was significantly longer (242.5 min) and the number of retrieved lymph nodes significantly lower (30.4) in the high BMI group than in the low BMI group (223.7 min and 32.6 nodes (p \ 0.001 and p = 0.005), respectively). Further subgroup analysis according to the surgeon's volume showed that for surgeons wh...

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Is laparoscopic gastrectomy safe for western patients with gastric cancer with high body mass index?

Kanellos

2009

Surg Endosc

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“…The prognosis of advanced resectable gastric cancer is very poor [11][12][13]. Therefore, most efforts in the West have been focused on the development of effective adjuvant empirical chemotherapy, or most recently targeted therapy [14][15][16], rather than on achieving an appropriate locoregional tumor control by high-quality surgery including a standardized, Japanese-style D2 lymphadenectomy [17][18][19].…”

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Preventing and managing complications of laparoscopic gastrectomy

Hanisch

2009

Surg Endosc

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“…It is thought that the quality of surgery [6] including a standardized D2 lymphadenectomy can improve the survival of patients with stage 2 or 3 disease [7][8][9][10][11][12].…”

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confidence: 99%