Primary gastric leiomyosarcoma presenting as a giant polyp

Sequeira, Cristiana; Coelho, Mariana de Freitas; Santos, In�s; Lopes, Sara; Fonseca, Ricardo; Mangualde, Jo�o; Oliveira, Ana Paula Ligeiro de

doi:10.17235/reed.2022.9165/2022

Cited by 2 publications

(6 citation statements)

References 4 publications

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“…Gastrointestinal mesenchymal tumors are uncommon tumors, mostly gastrointestinal stromal tumors (GIST), with smooth muscle tumors (leiomyomas and leiomyosarcomas) and schwannomas being rarer. Gastrointestinal sarcomas are extremely rare tumors; most of them refer to leiomyosarcomas, the most frequent location is the stomach (< 1 % of gastric neoplasms) and its prognosis is very poor (1)(2)(3).…”

Section: Discussionmentioning

confidence: 99%

Digestive Pseudopolyposis as a Form of Presentation of Digestive Metastases of Primary Gastric Leiomyosarcoma

Lobete¹,

Garvin²,

Otero³

et al. 2023

Rev Esp Enferm Dig

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Section: Discussionmentioning

confidence: 99%

Digestive Pseudopolyposis as a Form of Presentation of Digestive Metastases of Primary Gastric Leiomyosarcoma

Lobete¹,

Garvin²,

Otero³

et al. 2023

Rev Esp Enferm Dig

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“…The majority of biopsy results can confirm leiomyosarcoma, whereas other cases indicated no abnormality. 16,19,23,29 Uncommon findings include hyperplastic polyp, 30 leiomyoma, 31 smooth muscle/spindle cell tumor, 9,15,32 sarcoma with muscular differentiation, 13 and dysplasia. 22 Fine needle aspiration/biopsy from some cases 4,10,16 revealed bundles of well-differentiated spindle cells with blunt-ended nuclei and eosinophilic cytoplasm, devoid of mitotic figures, typically indicate spindle cell neoplasia with myogenic differentiation.…”

Section: Biopsy and Fine Needle Aspiration/biopsymentioning

confidence: 99%

“…5,25,33 Morphologically, tumors may arise from the muscularis propria 14,[24][25][26] or the muscularis mucosae. 10,13,29,34 These tumors can exhibit well-circumscribed borders, comprised of spindle cells arranged in a fascicular pattern (Fig. 2).…”

Section: Macroscopy Histology Immunohistochemistry Stains Molecular T...mentioning

confidence: 99%

“…Helicobacter pylori may play a role in the development of gastric leiomyosarcoma, 4,5 given its involvement in the pathogenesis of gastric mucosa-associated lymphoid tissue lymphoma and carcinoma 6 . Previous medical histories such as gastroesophageal reflux disease, 7–9 gastritis, 10 GI tract leiomyoma, 4,11 gastric adenocarcinoma, 11 retinoblastoma 12,13 with germline mutation in RB1, mantle cell lymphoma, 14 Wilms tumor, 15 obesity, 16,17 colon cancer, gastric polyp, melanoma, and acoustic neuroma 5 have been reported.…”

Section: Epidemiology and Etiologymentioning

confidence: 99%

“…The majority of biopsy results can confirm leiomyosarcoma, whereas other cases indicated no abnormality 16,19,23,29 . Uncommon findings include hyperplastic polyp, 30 leiomyoma, 31 smooth muscle/spindle cell tumor, 9,15,32 sarcoma with muscular differentiation, 13 and dysplasia 22 …”

Section: Epidemiology and Etiologymentioning

confidence: 99%

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Gastric Leiomyosarcoma in Post–Gastrointestinal Stromal Tumor Era: Revisit

Wang,

Leng

2024

Advances in Anatomic Pathology

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Primary gastric leiomyosarcoma is an exceptionally rare disease. This review covers 41 post-gastrointestinal stromal tumor (GIST) era gastric leiomyosarcoma cases that are supported by immunohistochemistry markers. Other spindle cell lesions are also excluded through histological and immunohistochemistry evaluations. The patients range from 3 to 82 years old, with an average age of 54.6 years. The male-to-female ratio is 1.4:1, from diverse geographic areas. Patients may experience abdominal symptoms, and tumor sizes vary between 1 cm and 22 cm. Morphologically, tumors originate from the muscularis propria or the muscularis mucosae, well-circumscribed with spindle cells arranged in fascicule. Tumoral cells exhibit positivity for smooth muscle markers while being negative for GIST markers and others. The mitotic index ranges from 2 to 500/50 high power field. Ki-67 index varies from 15% to 70%. Management typically involves gastrectomy and other appropriate treatments, with tumor recurrence being uncommon. 56% of patients are alive, with 5 patients dying from this disease. Statistical analyses conducted on post-GIST era cases reveal that a mitotic index of ≥100/50 high power field, tumor recurrence, metastasis, or positive lymph nodes significantly correlate with prognosis.

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Primary gastric leiomyosarcoma presenting as a giant polyp

Cited by 2 publications

References 4 publications

Digestive Pseudopolyposis as a Form of Presentation of Digestive Metastases of Primary Gastric Leiomyosarcoma

Digestive Pseudopolyposis as a Form of Presentation of Digestive Metastases of Primary Gastric Leiomyosarcoma

Gastric Leiomyosarcoma in Post–Gastrointestinal Stromal Tumor Era: Revisit

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