Primary gastric Hodgkin's lymphoma

Hossain, Fahad S; Koak, Yashwant; Khan, F.

doi:10.1186/1477-7819-5-119

Cited by 18 publications

(17 citation statements)

References 21 publications

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“…In most of the gastric Hodgkin lymphoma cases, preoperative diagnosis of gastric Hodgkin lymphoma could not be made [10], as in our patient. This can be due to the relatively low rate of Reed-Steinberg cells in biopsy specimens and increasing prevalence of histologically similar diseases.…”

Section: Discussioncontrasting

confidence: 55%

Primary gastric Hodgkin lymphoma and metachronous early gastric carcinoma: a case report

Durnalı¹,

Tokluoğlu²,

Alkış³

et al. 2010

Med Oncol

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Primary Gastric Hodgkin lymphoma is seen very rarely. Primary gastric Hodgkin lymphoma and gastric carcinoma in same patient is very very rare entity. Almost all of the primary gastric lymphoma cases are non-Hodgkin lymphoma type. We report the case of 45-year-old man with 3-month history of abdominal pain and weight loss. Upper gastrointestinal endoscopic examination revealed an ulcerated polypoid mass on greater curve of stomach and histopathological examination of biopsy showed adenocarcinoma. After near total gastrectomy, gastric Hodgkin lymphoma diagnosis was made, and postoperative 4 courses of doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD) regimen were administered, and then total 3,600 cGy radiotherapy was delivered. After 7 years, during control examination, early gastric carcinoma was diagnosed. Our case is very rare entity of gastric Hodgkin lymphoma and metachronous gastric carcinoma. This case also shows the importance of follow-up of patients not only for the relapse of primary disease but also for the development of secondary malignancy which can be diagnosed at early curable stage.

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Section: Discussioncontrasting

confidence: 55%

Primary gastric Hodgkin lymphoma and metachronous early gastric carcinoma: a case report

Durnalı¹,

Tokluoğlu²,

Alkış³

et al. 2010

Med Oncol

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“…However, in some cases, careful differential diagnosis through the use of a full panel of immunohistochemical markers is necessary to exclude other disease entities, in which there are similarities with both histopathological features and the presence of HRS-like cells in tumors [4,8]. Phenotypically, the HRS cells were positive for CD30 in nearly all cases, for CD15 in the majority (75 to 85%) of cases and variable expressions of B-cell markers such as CD20 and CD79a [4,8]. In addition, these cells are negative for EMA, T-cell markers and ALK-1.…”

Section: Discussionmentioning

confidence: 99%

Primary gastric Hodgkin's lymphoma

et al. 2012

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Gastric Hodgkin's lymphoma is extremely rare. We present a case of primary Hodgkin's lymphoma arising in the stomach of a 65-year-old woman. The patient complained of epigastric discomfort and reflux for one month. Endoscopic examination revealed a protruding lesion characterized by a smooth surface at the antrum. An abdominal computed tomography uncovered a 2.5 × 2.0 cm, exophytic submucosal mass. After the tentative preoperative diagnosis of a gastrointestinal stromal tumor, a gastric wedge resection was performed. Microscopic examination of the mass demonstrated a diffuse proliferation of large atypical lymphoid cells with mono- and binucleated pleomorphic nuclei and prominent nucleoli. Immunohistochemically, the tumor cells were positive for CD30, CD20, and CD79a, whereas they were negative for cytokeratin, carcinoembryonic antigen, CD3, CD15, epithelial membrane antigen, and anaplastic lymphoma kinase-1. Based on the morphological features and immunohistochemical results, in addition to the clinical findings, a diagnosis of primary gastric Hodgkin's lymphoma was established.

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“…Gastric infiltration with malignancy is a relatively commonly encountered scenario observed in clinical practice with gastric adenocarcinoma (90% of cases) and PGL (less than 5% of cases and usually of the non-Hodgkin's variety) being the more prevalent histological considerations; however, PGHL remains a rare clinical entity, prior to confirmation by histology and immunohistochemistry, and is reported as being less than 1% of all PGLs 5–7. The demographic profile for patients with PGHL with mediastinal involvement in the literature shows a female preponderance and tends to occur in older patients; the median age listed in pooled data in the literature ranges from 27–50 years of age 8.…”

Section: Discussionmentioning

confidence: 99%

Primary gastric Hodgkin's lymphoma: favourable outcome following multi-agent chemotherapy without surgical intervention

Quintyne

Mulcahy²,

Wallis³

et al. 2011

Case Reports

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Primary gastric Hodgkin's lymphoma

Abstract: Background: Primary Hodgkin's disease of the stomach is an extremely rare entity. Nearly all cases of primary gastric lymphoma are of the non-Hodgkin's variety. Diagnoses in such cases are difficult due to considerable histological similarities between the 2 disease entities.

Cited by 18 publications

References 21 publications

Primary gastric Hodgkin lymphoma and metachronous early gastric carcinoma: a case report

Primary gastric Hodgkin lymphoma and metachronous early gastric carcinoma: a case report

Primary gastric Hodgkin's lymphoma

Primary gastric Hodgkin's lymphoma: favourable outcome following multi-agent chemotherapy without surgical intervention

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