Primary form of malignant melanoma in an ovarian mature cystic teratoma: case report and literature review

Samiee-Rad, Fatemeh; Zangivand, Amir Abdollah; Soleimanitadi, Kamran

doi:10.1007/s00580-017-2475-6

Cited by 2 publications

(3 citation statements)

References 11 publications

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“…A review of cases of primary malignant melanoma of the ovary revealed that it is extremely rare and has poor prognosis [9]. The strongest prognostic factors reported in that review article were negative resection margins and stage at diagnosis.…”

Section: Discussionmentioning

confidence: 99%

A Case of Malignant Melanoma Arising in Mediastinal Malignant Teratoma

Nozaki

Tone

Yamanaka

et al. 2018

Case Reports in Pediatrics

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We report about a 14-year-old boy who presented with an anterior mediastinal mass that was diagnosed as malignant teratoma. Surgical resection was performed along with pre- and postoperative chemotherapy. Although elevated alpha-fetoprotein became negative, he experienced pain in his right hip joint 3 months after resection. Systematic evaluation revealed multiple locations of metastasis, and the pathological diagnosis based on bone biopsy was malignant melanoma originating from malignant teratoma, which rapidly progressed. He died 15 months after diagnosis of the original malignant teratoma. Diagnosing and treating malignant transformation of teratoma, including malignant melanoma, is difficult because it is very rare. To our knowledge, this is the second reported case of malignant melanoma arising from a mediastinum malignant teratoma, with both cases having a poor prognosis. In addition to the follow-up of tumor markers, systematic evaluation, including imaging, should be considered even after remission to monitor malignant transformation of teratoma. We expect to establish a successful therapy and improve mortality rate after more such cases are accumulated.

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Section: Discussionmentioning

confidence: 99%

A Case of Malignant Melanoma Arising in Mediastinal Malignant Teratoma

Nozaki

Tone

Yamanaka

et al. 2018

Case Reports in Pediatrics

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“…A characteristic feature of most melanoma cells is the possession of melanin intracellularly, but the amelanotic melanoma should also be remembered [40]. In both cases, immunohistochemical assay, which shows immunopositivity for HMB45, S100, vimentin, Melan-A, is crucial in making the diagnosis [36,[38][39][40]44]. All analyzed cases had confirmed melanoma with selected immunohistochemical markers.…”

Section: Characteristicsmentioning

confidence: 99%

“…Complementary treatment includes intravenous chemotherapy (mostly platinum-based) and immunotherapy (interferon-α). These drugs are used in various combinations [31,33,35,36,41,42,44]. Hormonotherapy like tamoxifen is used much less frequently [41].…”

Section: Treatmentmentioning

confidence: 99%

Therapeutic Management of Rare Primary Ovarian Neoplasms: Carcinosarcoma, Leiomyosarcoma, Melanoma and Carcinoid

Kozłowski

Nowak

Kordek

et al. 2021

IJERPH

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Carcinosarcoma, leiomyosarcoma, melanoma and carcinoid as primary tumors in the ovary are extremely rare. In this paper, the authors reviewed the literature from 2010 to 2021, based on specific criteria, to analyze the treatment of these rare ovarian neoplasms. We also aimed to verify whether modern therapies have been found in recent years. For this article, 80 papers were finally selected. The vast majority of the articles were clinical case reports. Despite single mentions of new potential pharmacological treatments, surgery (radical or fertility-sparing) is definitely the mainstay of treatment. There are currently no treatment guidelines for these tumors. A review of the literature has revealed the use of various adjuvant treatments. We, therefore, believe that a more detailed understanding of the biology of these tumors is necessary in order to find new target points for treatment. We would like to emphasize the importance of creating an international database of rare ovarian tumors which would make it possible to gather data from various oncological centers and enable further research into these neoplasms.

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Primary form of malignant melanoma in an ovarian mature cystic teratoma: case report and literature review

Cited by 2 publications

References 11 publications

A Case of Malignant Melanoma Arising in Mediastinal Malignant Teratoma

A Case of Malignant Melanoma Arising in Mediastinal Malignant Teratoma

Therapeutic Management of Rare Primary Ovarian Neoplasms: Carcinosarcoma, Leiomyosarcoma, Melanoma and Carcinoid

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