Primary Follicular Lymphoma of the Duodenum

Graham, Robbie L.; Mardones, Mabel A.; Krause, John R.

doi:10.1080/08998280.2015.11929284

Cited by 8 publications

(14 citation statements)

References 7 publications

(10 reference statements)

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“…Studies show that small intestine is involved in 64 to 94% of cases [5]. Contrary to Lebrun and al [7] who found a special predilection of GI-FL in the terminal ileum, most of the latest GI-FL reported affected the duodenum [4,6,8]. But in many studies, small intestine follicular lymphomas have a predominantly multifocal nature.…”

Section: Discussionmentioning

confidence: 94%

“…It is estimated that 70% of patients with GI-FL have multiple lesions along the gastrointestinal tract [4,6]. Indeed, most of the primary GI-FL patients had disease localized to the small intestine, but the disease can be present in the other parts of the GI tract such as the stomach or the colon [3,8]. According to Damaj [1], the high frequency of small intestine involvement is probably related to the relative abundance of normal lymphoid follicles in this region.…”

Section: Discussionmentioning

confidence: 99%

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A case Report of Perforated Primary Follicular Lymphoma of the Jejunum presenting as Aneurismal Form

Wade¹

2018

Arch Clin Gastroenterol

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Primary Gastrointestinal Follicular Lymphoma is very rare. It is considered as an indolent lymphoma, but a complication such as a perforation can increase the morbidity and mortality. We report the case of a 57-years-old man who had a perforation primary follicular lymphoma of the jejunum presenting as aneurismal form. He had peritonitis at his admission, and his abdominal CT revealed a massive pneumoperitoneum and a segmental dilatation of the small intestine. The surgical exploration found a segmental dilatation of the jejunum perforated on its ante-mesenteric side with a large mesenteric lymphadenopathy. Histological and immunohistochimical of the samples shown a jejunal follicular lymphoma. The patient died of heart failure 6 months after his surgery before he has started his chemotherapy. There is no consensus for the treatment of gastrointestinal follicular lymphoma, but chemotherapy is the most common strategy. Surgery is performed for a complication such as a perforation. A complication of a gastrointestinal follicular lymphoma contributes to increase the mortality.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

A case Report of Perforated Primary Follicular Lymphoma of the Jejunum presenting as Aneurismal Form

Wade¹

2018

Arch Clin Gastroenterol

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“…Normal follicles have tingible body macrophages in contrast to the neoplastic follicles in PFL-D. Centrocyte predominance lacking normal polarization is another characteristic of the neoplastic follicle [5]. Strong immunopositivity for Bcl-2 and low immunopositivity for Ki-67 in the neoplastic follicles in addition to CD10 and Bcl-6–positive cells in extrafollicular region are also distinguishing features of PFL-D from benign follicular hyperplasia [6]. In the gastrointestinal tract, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) and diffuse large B-cell lymphoma (DLBCL) are the most common extranodal non-Hodgkin lymphoma.…”

Section: Discussionmentioning

confidence: 99%

“…However, a majority of PFL-D including our case show severely disrupted follicular pattern as in the follicular colonization of the MALT lymphoma. CD21 or CD23 immunohistochemical stain highlights rearrangement of FDC around the periphery of the neoplastic follicles [2,6]. Takata et al .…”

Section: Discussionmentioning

confidence: 99%