Primary failure of eruption: From molecular diagnosis to therapeutic management

Wagner, Delphine; Rey, Tristan; Manière, Marie‐Cécile; Dubourg, Sarah; Bloch‐Zupan, Agnès; Strub, Marion

doi:10.1016/j.jobcr.2023.01.001

Cited by 6 publications

(12 citation statements)

References 28 publications

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“…This is known as primary failure of eruption, in which non-ankylosed teeth do not erupt because of a malfunction in the eruption mechanism. The exact cause is unknown; however, genetic disorders with variable penetrance and expression are the most likely explanation [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Forced eruption in impacted teeth: analysis of failed cases and outcome of re-operation

Kim,

Jung,

Lee

et al. 2024

BMC Oral Health

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Background Forced eruption of an impacted tooth usually requires surgical and orthodontic interventions to successfully bring the tooth into the dental arch. The clinical time required for a forced eruption is difficult to predict before treatment begins and success rates are affected by several factors before and after an eruption. This study was conducted to identify factors that affect the success of forced eruption, the duration of orthodontic treatment of impacted teeth, and the reasons for re-operation and forced eruption failure in a various teeth and cases. Methods In this retrospective study, the records regarding the forced eruption of 468 teeth in 371 patients from June 2006 to May 2020 at the Advanced General Dentistry Department of Yonsei University Dental Hospital were initially examined. The records of 214 teeth in 178 patients who completed orthodontic treatment were included in the analysis. Data on patient demographics, tooth characteristics, orthodontic treatment duration, re-operations, and failures were collected from electronic medical records. Results There was a significant difference in age between the success and failure forced eruption. Factors significantly affecting treatment duration were apex formation, position, rotation, and re-operation. Re-operation had a 96% success rate. The average orthodontic treatment duration was 29.99 ± 16.93 months, but the average orthodontic treatment duration for teeth that undergone re-operation was 20.36 ± 11.05 months, which was approximately 9 months shorter. Additionally, there was an interaction effect between rotation and re-operation on the duration of orthodontic treatment. The causes for failure of forced eruption in 6 cases were ankyloses (3 cases), incomplete alignment with the normal dental arch (2 cases), and a significant deviation in the impacted tooth’s location (1 case). Conclusions To increase the success rate of forced eruption, age should be considered as a priority, and in order to predict the treatment period, the apex formation status, position in the arch, and rotation should be considered in addition to age. When determining re-operation, considering factors such as ankylosis, root curvature, and apex formation can help in the success of orthodontic treatment.

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Section: Discussionmentioning

confidence: 99%

Forced eruption in impacted teeth: analysis of failed cases and outcome of re-operation

Kim,

Jung,

Lee

et al. 2024

BMC Oral Health

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“…Involved teeth are either completely retained or can erupt partially and then cease to erupt, remaining relatively submerged. As only lateral teeth are affected, the posterior open bite is the characteristic clinical feature, with functional impairment as a consequence [7,8]. The disorder may occur in any or all of the posterior quadrants, and it is rarely symmetric [4,7].…”

Section: Introductionmentioning

confidence: 99%

“…Clinical features and severity degrees may vary widely in non-syndromic PFE [8]. A systematic review performed by Hanisch et al (2018) on previous published studies 2 of 9 (2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017) on PFE summarized that girls tend to be slightly more affected (1.38:1 ratio), in almost 70% of the reported cases both molars and premolars were involved, primary teeth were affected in only about ¼ of the situations, while in most cases (75.7%) PFE was limited to permanent teeth and the condition was more frequently bilateral (64%) [5].…”

Section: Introductionmentioning

confidence: 99%

“…Alterations in two genes have been associated with PFE so far. Mutations in parathyroid hormone receptor 1 (PTH1R) have been identified in several familial cases of PFE [2,8,10]. Decker et al (2008) first reported that a variant in PTH1R was associated with PFE.…”

Section: Introductionmentioning

confidence: 99%

“…Orthodontic traction is therefore not to be attempted when the diagnosis of PFE is confirmed [4,10,15,18]. Treatment of PFE requires an interdisciplinary approach [8,18]. Each case needs to be carefully evaluated, and treatment planning must be carried out in accordance with the clinical situation and the patient's age [5].…”

Section: Introductionmentioning

confidence: 99%

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Rare Case of First Permanent Molar Primary Failure of Eruption with Agenesis of Premolars

Vinereanu,

Munteanu,

Clauss

et al. 2024

Children

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Primary failure of eruption (PFE) is a rare non-syndromic condition involving total or partial non-eruption of posterior teeth in the absence of mechanical obstruction. This paper presents the case of a healthy girl referred at age 4 for asymmetry of the upper arch. Clinical examination confirmed a slight shift of the upper midline to the left, with no erupted teeth distal to the upper left canine and a left posterior open bite. Panoramic X-rays showed delayed intraosseous development of the lateral left upper teeth compared to the right side. Clinic and radiographic follow-up during the next 9 years showed that 26 had not erupted by almost 13 years of age, 27 had delayed development and an unusual shape, and there was an agenesis in 24 and 25. Genetic analysis using the PTH1R single-gene sequencing method did not detect any known disease-causing or rare pathogenic variants that could explain the patient’s phenotype. Even when detected early, PFE raises difficult problems with regard to diagnosis and ortho-surgical treatment planning due to the impossibility of accurately predicting its evolution. Tooth agenesis on the same arch worsens the prognosis and adds challenges to planning the treatment. Close long-term follow-up and timely adjustment of the treatment plan in accordance with the evolution of the case are needed.

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Etiological Mechanisms and Genetic/Biological Modulation Related to PTH1R in Primary Failure of Tooth Eruption

Li,

Wang,

et al. 2024

Calcif Tissue Int

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Primary failure of eruption: From molecular diagnosis to therapeutic management

Cited by 6 publications

References 28 publications

Forced eruption in impacted teeth: analysis of failed cases and outcome of re-operation

Forced eruption in impacted teeth: analysis of failed cases and outcome of re-operation

Rare Case of First Permanent Molar Primary Failure of Eruption with Agenesis of Premolars

Etiological Mechanisms and Genetic/Biological Modulation Related to PTH1R in Primary Failure of Tooth Eruption

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