Primary extranodal non-Hodgkin's lymphomas. Part 1: Gastrointestinal, cutaneous and genitourinary lymphomas

Zucca, Emanuele; Ricevuto, Enrico; Bertoni, Francesco; Cavalli, F.

doi:10.1023/a:1008282818705

Cited by 344 publications

(296 citation statements)

References 64 publications

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“…As a result, 18 patients were diagnosed as H. pylori uninfected and were included in this study. Their clinical staging was determined by upper gastrointestinal (GI) tract endoscopy, colonoscopy, bone marrow puncture, X-ray computed tomography (CT) and/or positron emitting tomography (PET), applying the Lugano staging system (Zucca et al 1997). The chimeric transcript of t(11;18)(q21;q21) API2-MALT1 gene was investigated in 11 patients by either reverse-transcriptase polymerase chain reaction or fluorescence in situ hybridization as previously described (Terai et al 2008).…”

Section: Patients and Follow Upmentioning

confidence: 99%

Eradication Therapy Is Effective for <i>Helicobacter pylori</i>-Negative Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

Asano

Iijima

Terai

et al. 2012

Tohoku J. Exp. Med.

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Mucosa-associated lymphoid tissue (MALT) lymphomas are extra-nodal B-cell lymphomas arising from MALT, and the most commonly affected organ is the stomach. Helicobacter pylori (H. pylori) eradication therapy with proton-pump inhibitors and antibiotics is the first-line therapy for H. pylori-positive gastric MALT lymphomas, but the effectiveness of the therapy for H. pylori-negative gastric MALT lymphomas remains controversial. Hence, we aimed to evaluate the effectiveness of this eradication therapy for H. pylorinegative MALT lymphomas. The H. pylori infection status of 158 gastric MALT lymphoma patients followed in our unit was judged by urea breath test, rapid urease test, histology of the biopsy specimen taken from the stomach during endocopy, and serum antibody against H. pylori. Seventeen patients that were negative for all four tests and did not have gastric mucosal atrophy were treated with antibiotic eradication therapy. The average age at diagnosis was 56.8 years old (range: 36-73 years), and the median follow-up period after H. pylori eradication in all 17 patients was 5.3 years (range: 0.3-12.7 years). Five patients (29.4%) achieved complete remission (CR) by eradication therapy alone. Comparison between the responding and non-responding patients revealed that the patients endoscopically diagnosed to have a single lesion of gastric MALT lymphoma were seen only in the responding group, whereas all non-responding patients had multiple lesions (P < 0.05). In conclusion, H. pylori eradication therapy achieved a favorable CR rate in H. pylori-negative gastric MALT lymphoma patients and could be considered as a first-line therapy, especially for patients with a single lesion.

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Section: Patients and Follow Upmentioning

confidence: 99%

Eradication Therapy Is Effective for <i>Helicobacter pylori</i>-Negative Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

Asano

Iijima

Terai

et al. 2012

Tohoku J. Exp. Med.

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“…These forms are referred to as primary extranodal lymphomas (pENL). At least one-fourth of the lymphomas are probably of extranodal origin (Isaacson, 1994;Zucca et al, 1997;Zucca et al, 1999;Ferry, 2008).…”

Section: Introductionmentioning

confidence: 99%

Primary Extra Nodal Non Hodgkin Lymphoma: A 5 Year Retrospective Analysis

Padhi¹,

Paul²,

Challa³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…The Lugano staging system for the classification of gastrointestinal lymphoma was used to determine the patients' clinical stages (17).…”

Section: Methodsmentioning

confidence: 99%

Colorectal Manifestation of Follicular Lymphoma

et al. 2016

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Objective Due to their rarity, the endoscopic features and clinical backgrounds of colorectal follicular lymphoma lesions have not yet been fully investigated. The aim of this study was to reveal the characteristics of this disease entity. Methods A database search performed at the Department of Pathology of our institute identified 12 follicular lymphoma patients with involvement in the cecum, colon, and/or rectum. Data regarding the endoscopic, radiological, biological, and pathological examinations performed were retrospectively reviewed from their clinical records. Results The mean age of the patients (5 men, 7 women) was 58.7 years. Five patients were classified as being Lugano system stage I, while the other seven patients were stage IV. In all of the patients, colorectal follicular lymphoma presented with papular (n=4), polypoid (n=4), and flat elevated lesions (n=4). No erosions or ulcers were seen in any of the lesions. The initial pathological diagnoses included extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (n=2) and colitis/proctitis with infiltration of inflammatory cells (n=3), in addition to the correct diagnosis of follicular lymphoma (n=7). Conclusion Colorectal involvement of follicular lymphoma shows no erosions or ulcers. These lesions could be macroscopically observed as papular, polypoid and flat elevated lesions. Making a correct diagnosis of this disease based on the findings of biopsied samples is sometimes challenging. In such cases, multiple biopsies and/or endoscopic mucosal resection is required, in addition to appropriate consultation with pathologists.

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Primary extranodal non-Hodgkin's lymphomas. Part 1: Gastrointestinal, cutaneous and genitourinary lymphomas

Cited by 344 publications

References 64 publications

Eradication Therapy Is Effective for <i>Helicobacter pylori</i>-Negative Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

Eradication Therapy Is Effective for <i>Helicobacter pylori</i>-Negative Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

Primary Extra Nodal Non Hodgkin Lymphoma: A 5 Year Retrospective Analysis

Colorectal Manifestation of Follicular Lymphoma

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