Primary Extranodal Non-Hodgkin's Lymphoma: Clinicopathological Features, Survival and Treatment Outcome in Two Cancer Centers of Southern Turkey

Mertsoylu, Hüseyin; Muallaoğlu, Sadık; Beşen, Ali Ayberk; Erdoğdu, Süleyman; Sezer, Ahmet; Sedef, Ali Murat; Köse, Fatih; Arıcan, Ali; Ozyilkan, Ozgür

doi:10.7314/apjcp.2014.15.17.7207

Cited by 12 publications

(12 citation statements)

References 17 publications

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“…Male preponderance with M:F ratio of 2.1:1 observed and is comparable to various studies reported in literature. [1,2,10] Also all the 25 cases of ENHL were immunocompetent and had no B symptoms, but however presented with signs and symptoms pertaining to location.…”

Section: Discussionmentioning

confidence: 99%

Histomorphological and Immunohistochemical Study of Extra Nodal Lymphoma

Vani¹,

Sandhyalakshmi²,

Sajjan³

et al. 2021

Ann of Pathol and Lab Med

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Background: NHL are heterogeneous group of hematolymphoid malignancy occurring in nodal and extra nodal sites. Extra nodal lymphoma (ENL) is distinct from nodal lymphomas due to varied anatomical location, morphological diversity. Methods: A retrospective observational study was conducted in the department of pathology from January 2011 till December 2019. Clinical details and other investigations were recorded. Gross morphological features were noted. Slides are reviewed microscopically and blocks were subjected to IHC for further typing cases were selected as per Dawson et al criteria. Result: During study period, ENL constituted 25 cases (29.4%) of the 85 cases of all NHL. Age range is 05 to 63 years with a mean age of 42.5 years. Male to female ratio is 2.2 :1.Head and neck is the most common site of ENHL constituting 19 cases(76%), next commonest location is in the GIT with 3 cases (12%). We had one each case of ENHL in testis, breast and spine (4% each). On IHC, 92% cases (23 cases) exhibited B cell phenotype and the remaining 08 % (02 cases) were of T cell phenotype. Conclusion: Lymphomas in the extra nodal sites are rare but has the propensity to occur in any anatomic site. Hence a differential of lymphoma to be considered in extra nodal site. Histology with IHC enables to differentiate from poorly differentiated carcinoma as the treatment modalities and prognosis varies.

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Section: Discussionmentioning

confidence: 99%

Histomorphological and Immunohistochemical Study of Extra Nodal Lymphoma

Vani¹,

Sandhyalakshmi²,

Sajjan³

et al. 2021

Ann of Pathol and Lab Med

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“…The most common histology seen in literature is DLBCL followed by Marginal Zone Lymphomas (MZL) (Wotherspoon AC et al, 1993;Mertsoylu H, 2014). In The current study DLBCL was the most common histological subtype, followed by follicular lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Primary extranodal lymphomas in the head and neck region- a retrospective study from a tertiary cancer centre in south india

Aravind¹,

Sangeetha²,

Sreejyothi³

et al. 2017

Int J Recent Sci Res

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“…Th ere are confl icting reports in the literature regarding involvement of the most common systems and sites. However most of the studies report gastrointestinal tract as the most common system involved followed by head and neck and central nervous system (CNS) [5,6,9,18,[20][21][22][23][24][32][33][34] . Bone, testis, thyroid, breast, orbit, skin, rarely adrenal glands, pancreas, and the genitourinary tract are among the other frequent sites [5,6,9,18,[20][21][22][23][24][32][33][34] .…”

Section: Discussionmentioning

confidence: 99%

Primary Extranodal Non-Hodgkin's Lymphomas: A Single Center Experience

Mufti

Samman

2016

Saudi J Intern Med

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Background: Primary extranodal non-Hodgkin's lymphoma is emerging as a common entity that presents with diverse clinical features, morphology and immunophenotyping patterns. Aim: The aim of this study is to analyze the clinicopathological and immunohistochemical features in patients with primary extranodal non-Hodgkin's lymphoma. Settings and Design: This is a retrospective observational study from pre-recorded hospital data. Materials and Methods: The data of all histologically confirmed patients with non-Hodgkin's lymphoma were retrieved to identify those confirmed as primary extranodal non-Hodgkin's lymphoma among patients attending King Abdulaziz University Hospital, Jeddah, Saudi Arabia over the last 12 years (January 2003 - May 2015). Retrieved data was analyzed with regards to the demography, clinical features, histopathological and immunohistochemical features. Lymphoma of the study group were classified according to World Health Organization classification of lymphomas 2008. Result: A total of 218 patients with histologically confirmed non-Hodgkin's lymphoma were identified. Seventy-nine (36.2%) had primary extranodal non-Hodgkin's lymphoma. The most common age group affected was 20-39 years for both genders. Gastrointestinal system was the most frequently involved system for both genders. Colon was the most common site involved among males, while thyroid and thymus were the most common sites involved among females. Diffuse large B cell lymphoma was the most common histological type. Conclusion: Primary extranodal non-Hodgkin's lymphoma is common in Saudi Arabia affecting males and females almost equally in the third and fourth decades of life, with diffuse large B cell lymphoma being the most common histologic subtype.

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Primary Extranodal Non-Hodgkin's Lymphoma: Clinicopathological Features, Survival and Treatment Outcome in Two Cancer Centers of Southern Turkey

Abstract: Background: The aim of this study was to assess the epidemiological and clinicopathological characteristics of primary extranodal non-Hodgkin's lymphoma (pENL) patients, focusing on treatment and survival outcome.

Cited by 12 publications

References 17 publications

Histomorphological and Immunohistochemical Study of Extra Nodal Lymphoma

Histomorphological and Immunohistochemical Study of Extra Nodal Lymphoma

Primary extranodal lymphomas in the head and neck region- a retrospective study from a tertiary cancer centre in south india

Primary Extranodal Non-Hodgkin's Lymphomas: A Single Center Experience

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