Primary extranodal head and neck classical Hodgkin lymphoma: A rare clinical case report

Abstract

The subcutaneous soft tissue of the forehead is a rare anatomic site for Hodgkin lymphoma (HL), and no such case has previously been reported in the literature, to the best of our knowledge. HLs commonly present in the nodal regions in the majority of patients, rarely occurring in extranodal sites, whereas primary extranodal lymphoma is less common and is more typical in cases of non-HL. The present study reports a novel case of extranodal head and neck classical HL (cHL), initially diagnosed as frontal fibroma. The present study describes an unusual case of subcutaneous soft tissue involvement of HL, aiming to enhance current levels of awareness for patients with extranodal symptoms. A 25-year-old male, who inadvertently detected a hard painless mass above the right superciliary arch 2 months prior to admission in April 2013 was eventually diagnosed with mixed cellularity cHL. Subsequent to six cycles of doxorubicin (Adriamycin), bleomycin, vindesine and dacarbazine chemotherapy, followed by four cycles of ifosfamide, gemcitabine, vinorelbine and prednisone chemotherapy, a satisfactory curative effect was obtained. In conclusion, it is proposed that lymphoma should be considered in the differential diagnosis of a mass involving the subcutaneous soft tissue.

Diagnostic challenge of soft tissue extranodal Hodgkin lymphoma in core-needle biopsy: case report

“…3,4 Among Chine patients the most commonly involved extranodal sites of HL are the liver and lung, followed by the bones. 5 Rare cases are also described as primary breast, 6,7 parotid gland, 8 thyroid, 9 rectosigmoid, 10,11 ileum, 12 and head and neck 13,14 HL. It is essential to determine whether extranodal involvement represents a primary manifestation or dissemination of systemic disease.…”

Retrospective evaluation of the epidemiological and overall survival characteristics of adult Hodgkin lymphoma cases registered to Ege University Hospital database

“…Yang ve ark yaptığı çalışmada en sık akciğer olmak üzere sırasıyla kemik, nazofarinks, parotis, beyin ve adrenal bez olmak üzere primer ekstranodal HL oranı %7,4 dolayında bulunmuştur (22). Ayrıca literatürde ki çalışmalara baktığımızda, primer ekstranodal HL oranı yaklaşık %5-10 dolayında bildirilmiştir (23,24). (13).…”